Endothelial cells assemble two distinct α6β4-containing vimentin-associated structures: Roles for ligand binding and the β4 cytoplasmic tail

Journal of Cell Science

Volumn 111, Issue 18, 1998, Pages 2717-2728

  Homan, Suzanne M ^a   Mercurio, Arthur M ^b   LaFlamme, Susan E ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

6 4; cytoplasmic domain; Endothelial cell; HD1 plectin; Vimentin

Indexed keywords

FIBRONECTIN; INTEGRIN; INTERLEUKIN 2 RECEPTOR; KALININ; LAMININ; VIMENTIN;

ARTICLE; CELL LINE; CYTOSKELETON; ENDOTHELIUM CELL; HEMIDESMOSOME; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; INTERMEDIATE FILAMENT; LIGAND BINDING; PRIORITY JOURNAL;

ANTIGENS, SURFACE; BASE SEQUENCE; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; CYTOPLASM; DESMOSOMES; DNA PRIMERS; ENDOTHELIUM, VASCULAR; HUMANS; INTEGRIN ALPHA6BETA4; INTEGRINS; INTERMEDIATE FILAMENTS; LIGANDS; RECEPTORS, INTERLEUKIN-2; RECOMBINANT FUSION PROTEINS; TRANSFECTION; VIMENTIN;

EID: 0031754831     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Adams, J. C. and Watt, F. M. (1993). Regulation and development and differentiation by extracellular matrix. Development 117, 1183-1198.
2. Ades, E. A., Candal, F. J., Swerlick, R. A., George, V. G., Summers, S., Bosse, D. C. and Lawley, T. J. (1992). HMEC-1: Establishment of an immortalized human microvascular endothelial cell line. J. Invest. Derm. 99, 683-690.
3. Boukamp, P., Petrussevska, R. T., Brietkreutz, D., Hornung, J., Markham. A. and Fusenig, N. E. (1988). Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771.
4. Campbell, I. D. and Spitzfaden, C. (1994). Building proteins with fibronectin type III modules. Structure 2, 333-337.
5. Capco, D. G., Wan, K. M. and Penman, S. (1982). The nuclear matrix: three-dimensional architecture and protein composition. Cell 29, 847-858.
6. Carter, W. G., Gil, S. G., Symington, B. E., Brown, T. A., Hattori, S. and Ryan, M. C. (1994). Integrin receptors and epiligrin in cell-cell and cell-substrate adhesion in the epidermis. In Integrins: the Biological Problem (ed. Y. Takada,), pp. 147-176. CRC, London.
7. Clark, E. A. and Brugge, J. S. (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
8. Clarke, A. S., Lotz, M. M., Chao, C. and Mercurio, A. M. (1995). Activation of the p21 pathway of growth arrest and apoptosis by the β4 Integrin cytoplasmic domain. J. Biol. Chem. 270, 22673-22676.
9. Enenstein, J. and Kramer, R. H. (1994). Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin. J. Invest. Derm. 103, 381-386.
10. Foisner, R., Leichtfried, F. E., Herrmann, H., Small, J. V., Lawson, D. and Wiche, G. (1988). Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution and binding to immobilized intermediate filament proteins. J. Cell Biol. 106, 723-733.
11. Cache, Y., Chavanas, S., Lacour, J. P., Wiche, G., Owaribe, K., Meneguzzi, G. and Ortonne, J. P. (1996). Detective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy. J. Clin. Invest. 97, 2289-2298.
12. Giancotti, F., Stepp, M. A., Suzuki, S., Engvall, E. and Ruoslahti, E. (1992). Proteolytic processing of endogenous and recombinant β4 integrin subunit. J. Cell Biol. 118, 951-959.
13. Green, K. J. and Jones, J. C. R. (1996). Desmosomes and hemidesmosomes: structure and function of molecular components. FASEB J. 10, 871-881.
14. Guo, L., Degenstein, L., Howling, J., Yu, Q. C., Wollmann, R., Perman, B. and Fuchs, E. (1995). Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelial and neurologic degeneration. Cell 81, 233-243.
15. Hieda, Y., Nishizawa, Y., Uematsu, J. and Owaribe, K. (1992). Identifcation of a new hemidesmosomal protein, HD1: A major, high molecular mass component of isolated hemidesmosomes. J. Cell Biol. 116, 1497-1506.
16. Hormia, M., Falk-Marzillier, J., Plopper, G., Tamura, R. N., Jones, J. C. R. and Quaranta, V. (1995). Rapid spreading and mature hemidesmosome formation in HaCat keratinocytes induced by incubation with soluble laminin-5r. J. Invest. Derm. 105, 557-561.
17. Hynes, R. O. (1992). Integrins: Versatility, modulation and signaling in cell adhesion. Cell 69, 11-25.
18. lzumi, K., Hirao, Y., Hopp, L. and Oyasu, R. (1981). In vitro induction of ornithine decarboxylase in urinary bladder carcinoma cells. Cancer Res. 41, 405-409.
19. Jones, J. C. R., Asmuth, J., Baker, S. E., Langhofer, M., Roth, S. I. and Hopkinson, S. B. (1994). Hemidesmosomes: extracellular matrix/intermediate filament connectors. Exp. Cell Res. 213, 1-11.
20. Kennel, S. J., Godfrey, V., Ch'ang, L. Y., Lankford, T. K., Foote, L. J. and Makkinje, A. (1992). The β4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice. J. Cell Sci. 101, 145-150.
21. Koukoulis, G. K., Virtanen, I., Korhonen, M., Laitinen, L., Quaranta, V. and Gould, V. E. (1991). Immunohistochemical localization of integrins in the normal, hyperplastic and neoplastic breast. Am. J. Pathol. 139, 787-799.
22. LaFlamme, S. E., Akiyama, S. K. and Yamada, K. M. (1992). Regulation of fibronectin receptor distribution. J. Cell Biol. 117, 437-447.
23. LaFlamme, S. E., Thomas, L. A., Yamada, S. S. and Yamada, K. M. (1994). Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration and matrix assembly. J. Cell Biol. 126, 1287-1298.
24. Langhofer, M., Hopkinson, S. B. and Jones, J. C. R. (1993). The matrix secreted by 804G cells contains laminin-related components that participate in hemidesmosome assembly in vitro. J. Cell Sci. 105, 753-764.
25. Lee, E. C., Lota, M., Steele, G. D. and Mercurio, A. M. (1992). The α6β4 integrin is a laminin receptor. J. Cell Biol. 117, 671-678.
26. McLean, W. H. I., Pulkkinen, L., Smith, F. J. D., Rugg, E. L., Lane, E. B., Bullrich, F., Burgeson, R. E., Amano, S., Hudson, D. L., Owaribe, K., et al. (1996). Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization. Genes Dev. 10, 1724-1735.
27. Niessen, C. M., Hulsman, E. H. M., Oomen, L. C. J. M., Kuikman, I. and Sonnenberg, A. (1997a). A minimal region on the integrin β4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J. Cell Sci. 110, 1705-1716.
28. 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Mol. Biol. Cell 8, 555-566.
29. Nikolic, B., Mac Nulty, E., Mir, B. and Wiche, G. (1996). Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions. J. Cell Biol. 134, 1455-1467.
30. Rabinovitz, I. and Mercurio, A. M. (1997). The integrin α6β4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J. Cell Biol. 139, 1873-1884.
31. Rezniczek, G. A., de Pereda, J. M., Reipert, S. and Wiche, G. (1998). Linking integrin α6β4-based cell adhesion to the intermediate filament cytoskeleton: direct interaction between the β4 subunit and plectin at multiple molecular sites. J. Cell Biol. 141, 209-225.
32. Sambrook, J., Fritsch, E. F and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
33. Sanchez-Aparicio, P., Martinez de Velasco, A. M., Niessen, C. M., Borradori, L., Kuikman, L., Hulsman, E. H. M., Fassler, R., Owaribe, K. and Sonnenherg, A. (1997). The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin β4 subunit. J. Cell Sci. 110, 169-178.
34. Sastry, S. K. and Horwitz, A. F. (1993). Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling. Curr. Opin. Cell Biol. 5, 819-831.
35. Shaw, L. M., Lotz, M. M. and Mercurio, A. M. (1993). lnside-out signaling in macrophages: analysis of the role of the α6Aβ1 and α6Bβ1 integrin variants in laminin adhesion by cDNA expression in an α6 integrin-deficient macrophage cell line. J. Biol. Chem. 268, 11401-1408.
36. Shaw, L. M., Rabinovitz, I., Wang, H. H. F., Token A. and Mercurio, A. M. (1997). Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion. Cell 91, 949-960.
37. Skalli, O., Jones, J. C. R., Gagescu, R. and Goldman, R. D. (1994). IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments 10 these junctions. J. Cell Biol. 125, 159-170.
38. Smith, F. J. D., Eady, R. A. J., Leigh, I. M., McMillan, J. R., Rugg, E. L., Kelsell, D. P., Bryant, S. P., Spurr, N. K., Geddes, J. F., Kirtschig, G., et al. (1996). Plectin deficiency results in muscular dystrophy with epidermolysis bullosa. Nature Genetics 13, 450-457.
39. Spinardi, L., Einheber, S., Cullen, T., Milner, T. A. and Giancotti, F. (1995). A recombinant tail-less integrin β4 subunit disrupts hemidesmosomes but does not suppress α6β4-mediated cell adhesion to laminins. J. Cell Biol. 129, 473-487.
40. Spinardi, L., Ren, Y. L., Sanders, R. and Giancotti, F. (1993). The β4 subunit cytoplasmic domain mediates the interaction of α6β4 integrin with the cytoskeleton of hemidesmosomes. Mol. Biol. Cell 4, 871-884.
41. Stepp, M. A., Spurr-Michaud, S., Tisdale, A., Elwell, J. and Gipson, I. K. (1990). α6β4 integrin heterodimer is a component of hemidesmosomes. Proc. Nat. Acad. Sci. USA 87, 8970-8974.
42. Suzuki, S. and Naitoh, Y. (1990). Amino acid sequence of a novel integrin β4 subunit and primary expression of the mRNA in epithelial cells. EMBO J. 9, 757-763.
43. fyn sre homology 4 domain define a motif for immunereceptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization. J. Cell Biol. 133, 1007-1015.
44. Uematsu, J., Nishizawa, Y., Sonnenberg, A. and Owaribe, K. (1994). Demonstration of type II hemidesmosomes in a mammary gland epithelial cell line. BMGE-H. J. Biochem. 115, 469-476.
45. Xu, Y., Swerlick, R. A., Sepp, N. T., Bosse, D. C., Ades, E. A. and Lawley, T. J. (1994). Characterization of expression and modulation of cell adhesion molecules on an immortalized human dermal microvascular endothelial cell line (HMEC-1). J. Invest. Derm. 102, 833-837.
46. Yamada, K. M. and Miyamoto, S. (1995). Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7, 681-689.