Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 15066-15075

  Law, Ivy Ka Man ^a   Murphy, Jane E ^b   Bakirtzi, Kyriaki ^a   Bunnett, Nigel W ^b,c   Pothoulakis, Charalabos ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; ARRESTINS; COLONOCYTES; ENDOSOMES; EPITHELIAL CELLS; GENE SILENCING; HIGH AFFINITY; INFLAMMATORY SIGNALING; INTESTINAL INFLAMMATION; INTRACELLULAR TRAFFICKING; MAP KINASE; NEUROPEPTIDES; NEUROTENSIN; NUCLEAR TRANSLOCATIONS; PRE-TREATMENT; PROINFLAMMATORY;

CELL PROLIFERATION; CELLS; GENETIC ENGINEERING; MOLECULAR BIOLOGY; PHOSPHORYLATION; RECYCLING;

ENZYMES;

BETA ARRESTIN 1; BETA ARRESTIN 2; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NEUROTENSIN; NEUROTENSIN RECEPTOR; NEUROTENSIN RECEPTOR 1; SM 19712; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL LINE; CELL PROLIFERATION; CELL STRAIN NCM460; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOCYTOSIS; ENDOSOME; ENTERITIS; ENZYME PHOSPHORYLATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTERNALIZATION; INTESTINE CELL; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROINFLAMMATORY SIGNALING; PROTEIN DEGRADATION; PROTEIN TRANSPORT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ARRESTINS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; COLON; ENDOCYTOSIS; HUMANS; INFLAMMATION; INTERLEUKIN-8; INTESTINAL MUCOSA; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; METALLOENDOPEPTIDASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUROTENSIN; PROTEOLYSIS; RECEPTORS, NEUROTENSIN; SULFONAMIDES; SULFONYLUREA COMPOUNDS; TRANSCRIPTION FACTOR RELA;

EID: 84860360712     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.327262     Document Type: Article

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