Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 123-136

  Thapa, Pritam ^a   Karki, Radha ^a   Yun, Minho ^a   Kadayat, Tara Man ^a   Lee, Eunyoung ^b   Kwon, Han Byeol ^b   Na, Younghwa ^c   Cho, Won Jea ^d   Kim, Nam Doo ^e   Jeong, Byeong Seon ^a   Kwon, Youngjoo ^b   Lee, Eung Seok ^a  

^a Yeungnam University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Cha University   (South Korea)

^d Chonnam National University   (South Korea)

^e Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

2,4,6 Triaryl pyridine; Antitumor; Cytotoxicity; Terpyridine; Topoisomerase I and II inhibition

Indexed keywords

3 [2 (3 CHLOROPHENYL) 6 (THIOPHEN 2 YL)PYRIDIN 4 YL]PHENOL; 3 [2 (3 CHLOROPHENYL) 6 PHENYLPYRIDIN 4 YL]PHENOL; 3 [2 (4 CHLOROPHENYL) 6 (THIOPHEN 2 YL)PYRIDIN 4 YL]PHENOL; 3 [2 (4 CHLOROPHENYL) 6 (THIOPHEN 3 YL)PYRIDIN 4 YL]PHENOL; 3 [2 (4 CHLOROPHENYL) 6 PHENYLPYRIDIN 4 YL]PHENOL; 4 [2 (4 CHLOROPHENYL) 6 (FURAN 2 YL)PYRIDIN 4 YL]PHENOL; 4 [2 (4 CHLOROPHENYL) 6 (THIOPHEN 2 YL)PYRIDIN 4 YL]PHENOL; 4 [2 (4 CHLOROPHENYL) 6 (THIOPHEN 3 YL)PYRIDIN 4 YL]PHENOL; 4 [2 (4 CHLOROPHENYL) 6 PHENYLPYRIDIN 4 YL]PHENOL; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); PHENOL; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PHENOLS; PROTEIN CONFORMATION; PYRIDINES;

EID: 84860343547     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.010     Document Type: Article

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