Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 8, 2005, Pages 2065-2068

  Suzuki, Keitarou ^a   Okawara, Tadashi ^a   Higashijima, Tatuya ^a   Yokomizo, Kazumi ^a   Mizushima, Tohru ^a   Otsuka, Masami ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Anticancer; Isoaurostatin; Structure activity relationship; Topoisomerase

Indexed keywords

3 (3,4,5 TRIHYDROXYBENZYLIDENE) 5 HYDROXY 3H BENZOFURAN 2 ONE; ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; ETOPOSIDE; HYDROXYL GROUP; ISOAUROSTATIN A; ISOAUROSTATIN DERIVATIVE; KETONE DERIVATIVE; LACTONE; STATINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME INHIBITION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; INTERCALATION COMPLEX; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

THERMOBIFIDA ALBA; THERMOMONOSPORA;

EID: 15944415851     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.052     Document Type: Article

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