Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 219-228

  Karki, Radha ^a   Thapa, Pritam ^a   Yoo, Han Young ^a   Kadayat, Tara Man ^a   Park, Pil Hoon ^a   Na, Youngwha ^b   Lee, Eunyoung ^c   Jeon, Kyung Hwa ^c   Cho, Won Jea ^d   Choi, Heesung ^e   Kwon, Youngjoo ^c   Lee, Eung Seok ^a  

^a Yeungnam University   (South Korea)

^b Cha University   (South Korea)

^c Ewha Womans University   (South Korea)

^d Chonnam National University   (South Korea)

^e Eli Lilly Korea Ltd   (South Korea)

Author keywords

Anticancer agents; Cytotoxicity; Dihydroxylated 2,4,6 triphenyl pyridines; Topoisomerase I; Topoisomerase I.I.

Indexed keywords

1 (2 HYDROXYPHENYL) 3 (3 HYDROXYPHENYL)PROPENONE; 1 (2 HYDROXYPHENYL) 3 (4 HYDROXYPHENYL)PROPENONE; 1 (3 HYDROXYPHENYL) 3 (4 HYDROXYPHENYL)PROPENONE; 1,3 BIS(2 HYDROXYPHENYL)PROPENONE; 1,3 BIS(3 HYDROXYPHENYL)PROPENONE; 1,3 BIS(4 HYDROXYPHENYL)PROPENONE; 2 [2 (3 HYDROXYPHENYL) 6 PHENYLPYRIDIN 4 YL]PHENOL; 2 [2 (4 HYDROXYPHENYL) 6 PHENYLPYRIDIN 4 YL]PHENOL; 2 [4 (3 HYDROXYPHENYL) 6 PHENYLPYRIDIN 2 YL]PHENOL; 2 [4 (4 HYDROXYPHENYL) 6 PHENYLPYRIDIN 2 YL]PHENOL; 2 [6 (3 HYDROXYPHENYL) 4 PHENYLPYRIDIN 2 YL]PHENOL; 2 [6 (4 HYDROXYPHENYL) 4 PHENYLPYRIDIN 2 YL]PHENOL; 2,2' (6 PHENYLPYRIDINE 2,4 DIYL)DIPHENOL; 2,4,6 TRIPHENYL PYRIDINE DERIVATIVE; 3 (2 HYDROXYPHENYL) 1 (3 HYDROXYPHENYL)PROPENONE; 3 (2 HYDROXYPHENYL) 1 (4 HYDROXYPHENYL)PROPENONE; 3 (3 HYDROXYPHENYL) 1 (4 HYDROXYPHENYL)PROPENONE; 3 [2 (4 HYDROXYPHENYL) 6 PHENYLPYRIDIN 4 YL]PHENOL; 3 [4 (4 HYDROXYPHENYL) 6 PHENYLPYRIDIN 2 YL]PHENOL; 3,3' (6 PHENYLPYRIDINE 2,4 DIYL)DIPHENOL; 4,4' (6 PHENYLPYRIDINE 2,4 DIYL)DIPHENOL; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR; HYDROXYL GROUP; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN DU 145; CELL STRAIN HCT 15; CELL STRAIN K 562; CELL STRAIN MCF 7; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HELA CELL; IC 50; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HUMANS; NEOPLASMS; PYRIDINES; TOPOISOMERASE INHIBITORS;

EID: 84857239566     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.015     Document Type: Article

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