Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 275-283

  Menendez, Christophe ^a,b   Chollet, Aurélien ^a,b   Rodriguez, Frédéric ^a,b   Inard, Cyril ^c   Pasca, Maria Rosalia ^d   Lherbet, Christian ^a,b   Baltas, Michel ^a,b  

^a CNRS   (France)

^b UPS)   (France)

^c INSTITUT CLAUDIUS REGAUD   (France)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

Enoyl ACP reductase; InhA; Inhibitor; Triazole; Tuberculosis

Indexed keywords

1 (3,4 DIMETHOXYPHENETHYL) 4 DODECYL 1H 1,2,3 TRIAZOLE; 4 BENZYL 1 NONYL 1H 1,2,3 TRIAZOLE; 4 BENZYL 1 OCTYL 1H 1,2,3 TRIAZOLE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); TRIAZOLE DERIVATIVE; TRICLOSAN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; ENZYME INHIBITORS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN CONFORMATION; TRIAZOLES;

EID: 84860336214     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.029     Document Type: Article

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