Design, synthesis, and biological evaluation of new cinnamic derivatives as antituberculosis agents

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1449-1461

  De, Prithwiraj ^a,b   Koumba Yoya, Georges ^a,b   Constant, Patricia ^a,c   Bedos Belval, Florence ^a,b   Duran, Hubert ^a,b   Saffon, Nathalie ^a,d   Daffé, Mamadou ^a,c   Baltas, Michel ^a,b  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b CNRS   (France)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^d Université Paul Sabatier   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETAMIDOETHYL 3 (4 METHOXYPHENYL)PROP 2 ENETHIOATE; 2 ACETAMIDOETHYL 3 [4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 ENETHIOATE; 2 ACETAMIDOETHYL 3 [4 (3,7 DIMETHYLOCTA 2,6 DIENYLOXY)PHENYL]PROP 2 ENETHIOATE; 3 (4 ETHOXYSTYRYL)[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE; 3 (4 METHOXYSTYRYL)[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE; 3 (4 TRIFLUOROMETHOXYSTYRYL)[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE; 3 [4 (2',2',2' TRIFLUOROETHOXY)STYRYL][1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE; 3 [4 (3 METHYLBUT 2 ENYLOXY)STYRYL][1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE; 3 [4 (3,7 DIMETHYLOCTA 2,6 DIENYLOXY)STYRYL][1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE; CINNAMIC ACID DERIVATIVE; N (2 ACETAMIDOETHYL) 3 (4 METHOXYPHENYL)PROP 2 ENAMIDE; N (2 ACETAMIDOETHYL) 3 [4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 ENAMIDE; N (2 ACETAMIDOETHYL) 3 [4 (3,7 DIMETHYLOCTA 2,6 DIENYLOXY)PHENYL]PROP 2 ENAMIDE; N (3 OXO 1,2 OXAZOLIDIN 4 YL) 3 (4 METHOXYPHENYL)PROP 2 ENAMIDE; N (PYRIDIN 2 YL) 3 (4 METHOXYPHENYL)PROP 2 ENAMIDE; N (PYRIDIN 2 YL) 3 [4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 ENAMIDE; N (PYRIDIN 2 YL) 3 [4 (3,7 DIMETHYLOCTA 2,6 DIENYLOXY)PHENYL]PROP 2 ENAMIDE; N' 3 (4 ETHOXYPHENYL) N' (PHTHALAZIN 1(2H)YLIDIENE)ACRYLOHYDRAZIDE; N' 3 (4 TRIFLUOROMETHOXYPHENYL) N' (PHTHALAZIN 1(2H)YLIDIENE)ACRYLOHYDRAZIDE; N' 3 [4 (2',2',2' TRIFLUOROETHOXY)PHENYL] N' (PHTHALAZIN 1(2H)YLIDIENE)ACRYLOHYDRAZIDE; N' 3 [4 (3 METHYLBUT 2 ENYLOXY)PHENYL] N' (PHTHALAZIN 1(2H)YLIDIENE)ACRYLOHYDRAZIDE; N' 3 [4 (3,7 DIMETHYLOCTA 2,6 DIENYLOXY)PHENYL] N' (PHTHALAZIN 1(2H)YLIDIENE)ACRYLOHYDRAZIDE; N' [3 (4 ETHOXYPHENYL)PROPENOYL]ISONICOTINOHYDRAZIDE; N' [3 (4 METHOXYPHENYL)PROPENOYL]ISONICOTINOHYDRAZIDE; N' [3 (4 TRIFLUOROMETHOXYPHENYL)PROPENOYL]ISONICOTINOHYDRAZIDE; N' [3 [4 (2',2',2' TRIFLUOROETHOXYPHENYL)]PROPENOYL]ISONICOTINOHYDRAZIDE; N' [3 [4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROPENOYL]ISONICOTINOHYDRAZIDE; N' [3 [4 (3,7 DIMETHYLOCTA 2,6 DIENYLOXY)PHENYL]PROPENOYL]ISONICOTINOHYDRAZIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTITUBERCULAR AGENTS; CINNAMATES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; HYDRAZINES; ISONIAZID; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PHTHALAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79952274039     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101510d     Document Type: Article

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