Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor

Journal of Immunology

Volumn 188, Issue 9, 2012, Pages 4200-4208

  Kitamura, Hidemitsu ^a   Kobayashi, Minoru ^a   Wakita, Daiko ^a   Nishimura, Takashi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; NEUROKININ 2 RECEPTOR; NEUROKININ A; POLYINOSINIC POLYCYTIDYLIC ACID; SUBSTANCE P; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNITY, CELLULAR; INTERFERON INDUCERS; INTERFERON-GAMMA; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEUROKININ A; NEUROTRANSMITTER AGENTS; POLY I-C; RECEPTORS, NEUROKININ-2; RNA, MESSENGER; SIGNAL TRANSDUCTION; TH1 CELLS; TOLL-LIKE RECEPTOR 3;

EID: 84860329360     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102521     Document Type: Article

References (46)

1. Lloyd, C. M., and E. M. Hessel. 2010. Functions of T cells in asthma: more than just T(H)2 cells. Nat. Rev. Immunol. 10: 838-848.
2. Barrett, N. A., and K. F. Austen. 2009. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity 31: 425-437.
3. Kim, H. Y., R. H. DeKruyff, and D. T. Umetsu. 2010. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat. Immunol. 11: 577-584.
4. Umetsu, D. T., and R. H. Dekruyff. 2010. Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma. J. Allergy Clin. Immunol. 125: 975-979.
5. Bush, A., and S. Saglani. 2010. Management of severe asthma in children. Lancet 376: 814-825.
6. Ohnishi, H., N. Miyahara, and E.W. Gelfand. 2008. The role of leukotriene B(4) in allergic diseases. Allergol. Int. 57: 291-298.
7. Barnes, P. J. 2008. Immunology of asthma and chronic obstructive pulmonary disease. Nat. Rev. Immunol. 8: 183-192. (Pubitemid 351323287)
8. Barnes, P. J. 2008. The cytokine network in asthma and chronic obstructive pulmonary disease. J. Clin. Invest. 118: 3546-3556.
9. Ashino, S., D. Wakita, Y. Shiohama, Y. Iwakura, K. Chamoto, T. Ohkuri, H. Kitamura, and T. Nishimura. 2010. A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-gamma production in order to induce airway hyperresponsiveness. Int. Immunol. 22: 503-513.
10. Ashino, S., D. Wakita, Y. Zhang, K. Chamoto, H. Kitamura, and T. Nishimura. 2008. CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung. Int. Immunol. 20: 259-266. (Pubitemid 351234393)
11. Kobayashi, M., S. Ashino, Y. Shiohama, D. Wakita, H. Kitamura, and T. Nishimura. 2012. IFN-γ elevates airway hyper-responsiveness via up-regulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model. Eur. J. Immunol. 42: 393-402.
12. Groneberg, D. A., S. Harrison, Q. T. Dinh, P. Geppetti, and A. Fischer. 2006. Tachykinins in the respiratory tract. Curr. Drug Targets 7: 1005-1010. (Pubitemid 44227583)
13. De Swert, K. O., and G. F. Joos. 2006. Extending the understanding of sensory neuropeptides. Eur. J. Pharmacol. 533: 171-181. (Pubitemid 43348345)
14. Patterson, R. N., B. T. Johnston, J. E. Ardill, L. G. Heaney, and L. P. McGarvey. 2007. Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux. Thorax 62: 491-495. (Pubitemid 46910126)
15. Mostafa, G. A., S. M. Reda, M. M. Abd El-Aziz, and S. A. Ahmed. 2008. Sputum neurokinin A in Egyptian asthmatic children and adolescents: relation to exacerbation severity. Allergy 63: 1244-1247.
16. Schelfhout, V., V. Van De Velde, C. Maggi, R. Pauwels, and G. Joos. 2009. The effect of the tachykinin NK(2) receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics. Ther. Adv. Respir. Dis. 3: 219-226.
17. Quartara, L., M. Altamura, S. Evangelista, and C. A. Maggi. 2009. Tachykinin receptor antagonists in clinical trials. Expert Opin. Investig. Drugs 18: 1843-1864.
18. Boot, J. D., S. de Haas, S. Tarasevych, C. Roy, L. Wang, D. Amin, J. Cohen, P. J. Sterk, B. Miller, A. Paccaly, et al. 2007. Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma. Am. J. Respir. Crit. Care Med. 175: 450-457. (Pubitemid 46354248)
19. Theoharides, T. C., B. Zhang, D. Kempuraj, M. Tagen, M. Vasiadi, A. Angelidou, K. D. Alysandratos, D. Kalogeromitros, S. Asadi, N. Stavrianeas, et al. 2010. IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc. Natl. Acad. Sci. USA 107: 4448-4453.
20. Monaco-Shawver, L., L. Schwartz, F. Tuluc, C. J. Guo, J. P. Lai, S. M. Gunnam, L. E. Kilpatrick, P. P. Banerjee, S. D. Douglas, and J. S. Orange. 2011. Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor. J. Leukoc. Biol. 89: 113-125.
21. Barros, P. O., T. B. Ferreira, M. M. Vieira, C. R. Almeida, C. F. Araújo-Lima, R. G. Silva-Filho, J. Hygino, R. M. Andrade, A. F. Andrade, and C. A. Bento. 2011. Substance P enhances Th17 phenotype in individuals with generalized anxiety disorder: an event resistant to glucocorticoid inhibition. J. Clin. Immunol. 31: 51-59.
22. Blum, A., T. Setiawan, L. Hang, K. Stoyanoff, and J. V. Weinstock. 2008. Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation. Infect. Immun. 76: 3651-3656.
23. Sun, J., R. D. Ramnath, R. Tamizhselvi, and M. Bhatia. 2009. Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proin-flammatory pathways in mouse macrophages. FASEB J. 23: 997-1010.
24. Chernova, I., J. P. Lai, H. Li, L. Schwartz, F. Tuluc, H. M. Korchak, S. D. Douglas, and L. E. Kilpatrick. 2009. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). J. Leukoc. Biol. 85: 154-164.
25. Pavlovic, S., C. Liezmann, S. M. Blois, R. Joachim, J. Kruse, N. Romani, B. F. Klapp, and E. M. Peters. 2011. Substance P is a key mediator of stress-induced protection from allergic sensitization via modified antigen presentation. J. Immunol. 186: 848-855.
26. Gleason, N. R., G. Gallos, Y. Zhang, and C. W. Emala. 2010. Propofol preferentially relaxes neurokinin receptor-2-induced airway smooth muscle contraction in guinea pig trachea. Anesthesiology 112: 1335-1344.
27. Tuluc, F., J. P. Lai, L. E. Kilpatrick, D. L. Evans, and S. D. Douglas. 2009. Neurokinin 1 receptor isoforms and the control of innate immunity. Trends Immunol. 30: 271-276.
28. Douglas, S. D., and S. E. Leeman. 2011. Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann. N. Y. Acad. Sci. 1217: 83-95.
29. Sculptoreanu, A., F. Aura Kullmann, and W. C. de Groat. 2008. Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. Eur. J. Neurosci. 27: 3171-3181. (Pubitemid 351863592)
30. Sun, J., R. D. Ramnath, R. Tamizhselvi, and M. Bhatia. 2008. Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways. Am. J. Physiol. Cell Physiol. 295: C679-C691.
31. Miotto, D., P. Boschetto, G. Cavallesco, E. Zeni, P. Querzoli, M. Pedriali, S. Chiarelli, L. M. Fabbri, and C. E. Mapp. 2007. Increased neurokinin-2 receptor expression in alveolar macrophages of smokers with COPD. Histopathology 51: 128-131. (Pubitemid 46976364)
32. Michalski, C. W., X. Shi, C. Reiser, P. Fachinger, A. Zimmermann, M. W. Büchler, P. Di Sebastiano, and H. Friess. 2007. Neurokinin-2 receptor levels correlate with intensity, frequency, and duration of pain in chronic pancreatitis. Ann. Surg. 246: 786-793. (Pubitemid 350035655)
33. Hernandez, J. M., G. Cox, and L. J. Janssen. 2008. Involvement of the neurokinin-2 receptor in airway smooth muscle stretch-activated contractions assessed in perfused intact bovine bronchial segments. J. Pharmacol. Exp. Ther. 327: 503-510.
34. Beresford, I. J., R. L. Sheldrick, D. I. Ball, M. P. Turpin, D. M. Walsh, A. B. Hawcock, R. A. Coleman, R. M. Hagan, and M. B. Tyers. 1995. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur. J. Pharmacol. 272: 241-248.
35. Kitamura, H., H. Morikawa, H. Kamon, M. Iguchi, S. Hojyo, T. Fukada, S. Yamashita, T. Kaisho, S. Akira, M. Murakami, and T. Hirano. 2006. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat. Immunol. 7: 971-977. (Pubitemid 44263911)
36. Kitamura, H., H. Kamon, S. Sawa, S. J. Park, N. Katunuma, K. Ishihara, M. Murakami, and T. Hirano. 2005. IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells. Immunity 23: 491-502. (Pubitemid 41587889)
37. Ohkuri, T., D. Wakita, K. Chamoto, Y. Togashi, H. Kitamura, and T. Nishimura. 2009. Identification of novel helper epitopes of MAGE-A4 tumour antigen: useful tool for the propagation of Th1 cells. Br. J. Cancer 100: 1135-1143.
38. Kincy-Cain, T., and K. L. Bost. 1996. Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II. J. Immunol. 157: 255-264. (Pubitemid 26190555)
39. Kincy-Cain, T., J. D. Clements, and K. L. Bost. 1996. Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin. Infect. Immun. 64: 1437-1440. (Pubitemid 26102414)
40. Walters, N., T. Trunkle, M. Sura, and D. W. Pascual. 2005. Enhanced immunoglobulin A response and protection against Salmonella enterica serovar typhimurium in the absence of the substance P receptor. Infect. Immun. 73: 317-324. (Pubitemid 40041123)
41. Kennedy, P. G., J. Rodgers, B. Bradley, S. P. Hunt, G. Gettinby, S. E. Leeman, C. de Felipe, and M. Murray. 2003. Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain 126: 1683-1690. (Pubitemid 36834944)
42. Reinke, E. K., M. J. Johnson, C. Ling, J. Karman, J. Lee, J. V. Weinstock, M. Sandor, and Z. Fabry. 2006. Substance P receptor mediated maintenance of chronic inflammation in EAE. J. Neuroimmunol. 180: 117-125. (Pubitemid 44692317)
43. Nessler, S., C. Stadelmann, A. Bittner, K. Schlegel, F. Gronen, W. Brueck, B. Hemmer, and N. Sommer. 2006. Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist - a putative role for substance P in CNS inflammation. J. Neuroimmunol. 179: 1-8. (Pubitemid 44441598)
44. Kamon, H., T. Kawabe, H. Kitamura, J. Lee, D. Kamimura, T. Kaisho, S. Akira, A. Iwamatsu, H. Koga, M. Murakami, and T. Hirano. 2006. TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J. 25: 4108-4119. (Pubitemid 44338751)
45. Reizis, B., A. Bunin, H. S. Ghosh, K. L. Lewis, and V. Sisirak. 2011. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 29: 163-183.
46. Blasius, A. L., and B. Beutler. 2010. Intracellular toll-like receptors. Immunity 32: 305-315.