Interleukin-12 (IL-12) and IL-23 induction of substance P synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor β regulation

Infection and Immunity

Volumn 76, Issue 8, 2008, Pages 3651-3656

  Blum, Arthur ^a   Setiawan, Tommy ^a   Hang, Long ^a   Stoyanoff, Korynn ^a   Weinstock, Joel V ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 23; RECOMBINANT INTERLEUKIN 3; STAT4 PROTEIN; SUBSTANCE P; TACHYKININ; TRANSFORMING GROWTH FACTOR BETA; STAT4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; GENE EXPRESSION; LEUKOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SCHISTOSOMIASIS; SPLEEN CELL; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; SPLEEN;

ANIMALS; GENE EXPRESSION PROFILING; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-23; MACROPHAGES; MICE; NF-KAPPA B; SCHISTOSOMIASIS; SPLEEN; STAT4 TRANSCRIPTION FACTOR; SUBSTANCE P; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 48849086421     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00358-08     Document Type: Article

References (29)

1. Arsenescu, R., A. M. Blum, A. Metwali, D. E. Elliott, and J. V. Weinstock. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation. J. Immunol. 174:3906-3911.
2. Blum, A. M., A. Metwali, G. Cook, R. C. Mathew, D. Elliott, and J. V. Weinstock. 1993. Substance P modulates antigen-induced, IFN-γ production in murine schistosomiasis mansoni. J. Immunol. 151:225-233.
3. Blum, A. M., A. Metwali, C. Crawford, J. Li, K. Qadir, D. E. Elliott, and J. V. Weinstock. 2001. Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni. FASEB J. 15:950-957.
4. Blum, A. M., A. Metwali, M. Kim-Miller, J. Li, K. Qadir, D. E. Elliott, B. Lu, Z. Fabry, N. Gerard, and J. V. Weinstock. 1999. The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni. J. Immunol. 162:6080-6085.
5. Castagliuolo, I., A. C. Keates, B. Qiu, C. P. Kelly, S. Nikulasson, S. E. Leeman, and C. Pothoulakis. 1997. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc. Natl. Acad. Sci. USA 94:4788-4793.
6. Castagliuolo, I., M. Riegler, A. Pasha, B. S. Nikulasson, Lu, C. Gerard, N. P. Gerard, and C. Pothoulakis. 1998. Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis. J. Clin. Investig. 101:1547-1550.
7. Cho, M. L., J. W. Kang, Y. M. Moon, H. J. Nam, J. Y. Jhun, S. B. Heo, H. T. Jin, S. Y. Min, J. H. Ju, K. S. Park, Y. G. Cho, C. H. Yoon, S. H. Park, Y. C. Sung, and H. Y. Kim. 2006. STAT3 and NF-κB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J. Immunol. 176:5652-5661.
8. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
9. Di Sebastiano, P., L. Grossi, F. F. di Mola, D. Angelucci, H. Friess, L. Marzio, P. Innocenti, and M. W. Buthler. 1999. SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis. Dig. Dis. Sci. 44:439-444.
10. Elliott, D. E. 1996. Methods used to study immunoregulation of schistosome egg granulomas. Immunomethods 9:255-267.
11. Ho, W. Z., J. P. Lai, X. H. Zhu, M. Uvaydova, and S. D. Douglas. 1997. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J. Immunol. 159:5654-5660.
12. Hunter, C. A. 2005. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5:521-531.
13. Kincy-Cain, T., and K. L. Bost. 1996. Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II. J. Immunol. 157:255-264.
14. Lai, J. P., S. D. Douglas, and W. Z. Ho. 1998. Human lymphocytes express substance P and its receptor. J. Neuroimmunol. 86:80-86.
15. Lambrecht, B. N., P. R. Germonpre, E. G. Everaert, I. Carro-Muino, M. De Veerman, C. de Felipe, S. P. Hunt, K. Thielemans, G. F. Joos, and R. A. Pauwels. 1999. Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation. Eur. J. Immunol. 29:3815-3825.
16. Langrish, C. L., B. S. McKenzie, N. J. Wilson, M. R. de Waal, R. A. Kastelein, and D. J. Cua. 2004. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev. 202:96-105.
17. Marriott, I., and K. L. Bost. 2000. IL-4 and IFN-gamma up-regulate substance P receptor expression in murine peritoneal macrophages. J. Immunol. 165:182-191.
18. Metwali, A., A. M. Blum, D. E. Elliott, T. Setiawan, and J. V. Weinstock. 2004. Cutting edge: hemokinin has substance P-like function and expression in inflammation. J. Immunol. 172:6528-6532.
19. Morteau, O., B. Lu, C. Gerard, and N. P. Gerard. 2001. Hemokinin 1 is a full agonist at the substance P receptor. Nat. Immunol. 2:1088.
20. Qadir, K., A. Metwali, A. M. Blum, J. Li, D. E. Elliott, and J. V. Weinstock. 2001. TGF-β and IL-10 regulation of IFN-γ produced in Th2-type schistosome granulomas requires IL-12. AJP Gastrointest. Liver Physiol. 281:G940-G946.
21. Ryu, S. Y., K. S. Jeong, W. K. Yoon, S. J. Park, B. N. Kang, S. H. Kim, B. K. Park, and S. W. Cho. 2000. Somatostatin and substance P induced in vivo by lipopolysaccharide and in peritoneal macrophages stimulated with lipopolysaccharide or interferon-gamma have differential effects on murine cytokine production. Neuroimmunomodulation 8:25-30.
22. Simeonidis, S., I. Castagliuolo, A. Pan, J. Liu, C. C. Wang, A. Mykoniatis, A. Pasha, L. Valenick, S. Sougioultzis, D. Zhao, and C. Pothoulakis. 2003. Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-κB site on its promoter. Proc. Natl. Acad. Sci. USA 100:2957-2962.
23. Sturiale, S., G. Barbara, B. Qiu, M. Figini, P. Geppetti, N. Gerard, C. Gerard, E. F. Grady, N. W. Bunnett, and S. M. Collins. 1999. Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. Proc. Natl. Acad. Sci. USA 96:11653-11658.
24. Watford, W. T., B. D. Hissong, J. H. Bream, Y. Kanno, L. Muul, and J. J. O'Shea. 2004. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 202:139-156.
25. Weinstock, J. V. 2004. The role of substance P, hemokinin and their receptor in governing mucosal inflammation and granulomatous responses. Front. Biosci. 9:1936-1943.
26. Weinstock, J. V., A. Blum, A. Metwali, D. Elliott, and R. Arsenescu. 2003. IL-18 and IL-12 signal through the NF-κB pathway to induce NK-1R expression on T cells. J. Immunol. 170:5003-5007.
27. Weinstock, J. V., A. Blum, A. Metwali, D. Elliott, N. Bunnett, and R. Arsenescu. 2003. Substance P regulates Th1-type colitis in IL-10 knockout mice. 1. Immunol. 171:3762-3767.
28. Weinstock, J. V., A. Blum, J. Walder, and R. Walder. 1988. Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P. J. Immunol. 141:961-966.
29. Weinstock, J. V., and A. M. Blum. 1989. Tachykinin production in granulomas of murine schistosomiasis mansoni. J. Immunol. 142:3256-3261.