Xin proteins and intercalated disc maturation, signaling and diseases

Frontiers in Bioscience

Volumn 17, Issue 7, 2011, Pages 2566-2593

  Wang, Qinchuan ^a   Lin, Jenny Li Chun ^a   Wu, Kuo Ho ^b   Wang, Da Zhi ^c   Reiter, Rebecca S ^a   Sinn, Haley W ^a   Lin, Cheng I ^b   Lin, Jim Jung Ching ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cardiomyopathy with conduction defects; Intercalated disc formation; Postnatal lethality; Review; Severe growth retardation; Xin repeats

Indexed keywords

MAMMALIA; MUS;

EID: 84860284298     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4072     Document Type: Article

References (213)

1. M.S. Forbes and N. Sperelakis: Intercalated discs of mammalian heart: a review of structure and function. Tissue Cell, 17, 605-48 (1985) (Pubitemid 16243839)
2. N.J. Severs: The cardiac gap junction and intercalated disc. Int J Cardiol, 26, 137-73 (1990) (Pubitemid 20035665)
3. J.C. Perriard, A. Hirschy and E. Ehler: Dilated cardiomyopathy: a disease of the intercalated disc? Trends Cardiovasc Med, 13, 30-8 (2003) (Pubitemid 36120547)
4. J.A. Palatinus, J.M. Rhett and R.G. Gourdie: The connexin43 carboxyl terminus and cardiac gap junction organization. Biochim Biophys Acta, (2011)
5. E. Garcia-Gras, R. Lombardi, M.J. Giocondo, J.T. Willerson, M.D. Schneider, D.S. Khoury and A.J. Marian: Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest, 116, 2012-21 (2006) (Pubitemid 44033325)
6. J. Li, V.V. Patel and G.L. Radice: Dysregulation of cell adhesion proteins and cardiac arrhythmogenesis. Clin Med Res, 4, 42-52 (2006)
7. M. Noorman, M.A. van der Heyden, T.A. van Veen, M.G. Cox, R.N. Hauer, J.M. de Bakker and H.V. van Rijen: Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling. J Mol Cell Cardiol, 47, 23-31 (2009)
8. S. Rohr: Molecular crosstalk between mechanical and electrical junctions at the intercalated disc. Circ Res, 101, 637-9 (2007) (Pubitemid 47494090)
9. F. Sheikh, R.S. Ross and J. Chen: Cell-cell connection to cardiac disease. Trends Cardiovasc Med, 19, 182-90 (2009)
10. N.J. Severs, A.F. Bruce, E. Dupont and S. Rothery: Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res, 80, 9-19 (2008)
11. J. Li and G.L. Radice: A new perspective on intercalated disc organization: implications for heart disease. Dermatol Res Pract, 2010, 207835 (2010)
12. C.B. Estigoy, F. Ponten, J. Odeberg, B. Herbert, M. Guilhuas, M. Charleston, J.W.K. Ho, D. Cameron and C.G. dos Remedies: Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts. Biophys Rev, 1, 43-49 (2009)
13. P.M. Bennett, A.M. Maggs, A.J. Baines and J.C. Pinder: The transitional junction: a new functional subcellular domain at the intercalated disc. Mol Biol Cell, 17, 2091-100 (2006) (Pubitemid 44011621)
14. D.Z. Wang, X. Hu, J.L. Lin, G.T. Kitten, M. Solursh and J.J. Lin: Differential displaying of mRNAs from the atrioventricular region of developing chicken hearts at stages 15 and 21. Front Biosci, 1, a1-15 (1996)
15. D.Z. Wang, R.S. Reiter, J.L. Lin, Q. Wang, H.S. Williams, S.L. Krob, T.M. Schultheiss, S. Evans and J.J. Lin: Requirement of a novel gene, Xin, in cardiac morphogenesis. Development, 126, 1281-94 (1999) (Pubitemid 29182123)
16. S.E. Grosskurth, D. Bhattacharya, Q. Wang and J.J. Lin: Emergence of Xin demarcates a key innovation in heart evolution. PLoS ONE, 3, e2857 (2008)
17. E.A. Gustafson-Wagner, H.W. Sinn, Y.L. Chen, D.Z. Wang, R.S. Reiter, J.L. Lin, B. Yang, R.A. Williamson, J. Chen, C.I. Lin and J.J. Lin: Loss of mXinα, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol, 293, H2680-92 (2007)
18. Q. Wang, J.L. Lin, B.E. Reinking, H.Z. Feng, F.C. Chan, C.I. Lin, J.P. Jin, E.A. Gustafson-Wagner, T.D. Scholz, B. Yang and J.J. Lin: Essential roles of an intercalated disc protein, mXinβ, in postnatal heart growth and survival. Circ Res, 16, 1468-78 (2010)
19. W.W. Franke, C.M. Borrmann, C. Grund and S. Pieperhoff: The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Eur J Cell Biol, 85, 69-82 (2006) (Pubitemid 43137112)
20. C.M. Borrmann, C. Grund, C. Kuhn, I. Hofmann, S. Pieperhoff and W.W. Franke: The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk. Eur J Cell Biol, 85, 469-85 (2006)
21. S. Pieperhoff and W.W. Franke: The area composita of adhering junctions connecting heart muscle cells of vertebrates -IV: coalescence and amalgamation of desmosomal and adhaerens junction components -late processes in mammalian heart development. Eur J Cell Biol, 86, 377-91 (2007) (Pubitemid 46971921)
22. S. Pieperhoff and W.W. Franke: The area composita of adhering junctions connecting heart muscle cells of vertebrates. VI. Different precursor structures in nonmammalian species. Eur J Cell Biol, 87, 413-30 (2008)
23. W.W. Franke, S. Rickelt, M. Barth and S. Pieperhoff: The junctions that don't fit the scheme: special symmetrical cell-cell junctions of their own kind. Cell Tissue Res, 338, 1-17 (2009)
24. E.R. Porrello, A.I. Mahmoud, E. Simpson, J.A. Hill, J.A. Richardson, E.N. Olson and H.A. Sadek: Transient regenerative potential of the neonatal mouse heart. Science, 331, 1078-80 (2011)
25. M. Eigenthaler, S. Engelhardt, B. Schinke, A. Kobsar, E. Schmitteckert, S. Gambaryan, C.M. Engelhardt, V. Krenn, M. Eliava, T. Jarchau, M.J. Lohse, U. Walter and L. Hein: Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Am J Physiol Heart Circ Physiol, 285, H2471-81 (2003) (Pubitemid 37443064)
26. X. Ma, K. Takeda, A. Singh, Z.X. Yu, P. Zerfas, A. Blount, C. Liu, J.A. Towbin, M.D. Schneider, R.S. Adelstein and Q. Wei: Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice. Circ Res, 105, 1102-9 (2009)
27. F. Sheikh, Y. Chen, X. Liang, A. Hirschy, A.E. Stenbit, Y. Gu, N.D. Dalton, T. Yajima, Y. Lu, K.U. Knowlton, K.L. Peterson, J.C. Perriard and J. Chen: alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation, 114, 1046-55 (2006) (Pubitemid 44358881)
28. A.E. Zemljic-Harpf, J.C. Miller, S.A. Henderson, A.T. Wright, A.M. Manso, L. Elsherif, N.D. Dalton, A.K. Thor, G.A. Perkins, A.D. McCulloch and R.S. Ross: Cardiacmyocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol, 27, 7522-37 (2007) (Pubitemid 350033658)
29. A. Sonnenberg and R.K. Liem: Plakins in development and disease. Exp Cell Res, 313, 2189-203 (2007) (Pubitemid 46842974)
30. G.I. Gallicano, P. Kouklis, C. Bauer, M. Yin, V. Vasioukhin, L. Degenstein and E. Fuchs: Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol, 143, 2009-22 (1998) (Pubitemid 29022620)
31. C. Basso, E. Czarnowska, M. Della Barbera, B. Bauce, G. Beffagna, E.K. Wlodarska, K. Pilichou, A. Ramondo, A. Lorenzon, O. Wozniek, D. Corrado, L. Daliento, G.A. Danieli, M. Valente, A. Nava, G. Thiene and A. Rampazzo: Ultrastructural evidence of intercalated disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron microscopy investigation on endomyocardial biopsies. Eur Heart J, 27, 1847-54 (2006) (Pubitemid 44297392)
32. M. Delmar and W.J. McKenna: The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease. Circ Res, 107, 700-14 (2010)
33. S.R. Kaplan, J.J. Gard, L. Carvajal-Huerta, J.C. Ruiz-Cabezas, G. Thiene and J.E. Saffitz: Structural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol, 13, 26-32 (2004) (Pubitemid 38169463)
34. Z. Yang, N.E. Bowles, S.E. Scherer, M.D. Taylor, D.L. Kearney, S. Ge, V.V. Nadvoretskiy, G. DeFreitas, B. Carabello, L.I. Brandon, L.M. Godsel, K.J. Green, J.E. Saffitz, H. Li, G.A. Danieli, H. Calkins, F. Marcus and J.A. Towbin: Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res, 99, 646-55 (2006) (Pubitemid 44401456)
35. S.R. Kaplan, J.J. Gard, N. Protonotarios, A. Tsatsopoulou, C. Spiliopoulou, A. Anastasakis, C.P. Squarcioni, W.J. McKenna, G. Thiene, C. Basso, N. Brousse, G. Fontaine and J.E. Saffitz: Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm, 1, 3-11 (2004) (Pubitemid 38647241)
36. L.M. Fidler, G.J. Wilson, F. Liu, X. Cui, S.W. Scherer, G.P. Taylor and R.M. Hamilton: Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations. J Cell Mol Med, 13, 4219-28 (2009)
37. A.F. Bruce, S. Rothery, E. Dupont and N.J. Severs: Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. Cardiovasc Res, 77, 757-65 (2008) (Pubitemid 351301863)
38. R.R. Kaprielian, M. Gunning, E. Dupont, M.N. Sheppard, S.M. Rothery, R. Underwood, D.J. Pennell, K. Fox, J. Pepper, P.A. Poole-Wilson and N.J. Severs: Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation, 97, 651-60 (1998) (Pubitemid 28090958)
39. J.H. Smith, C.R. Green, N.S. Peters, S. Rothery and N.J. Severs: Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy. Am J Pathol, 139, 801-21 (1991)
40. E. Dupont, T. Matsushita, R. Kaba, C. Vozzi, S.R. Coppen, N. Khan, R. Kaprielian, M.H. Yacoub and N.J. Severs: Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol, 33, 359-71 (2001) (Pubitemid 32537933)
41. S. Kostin, M. Rieger, S. Dammer, S. Hein, M. Richter, W.P. Klovekorn, E.P. Bauer and J. Schaper: Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem, 242, 135-44 (2003) (Pubitemid 36240539)
42. S. Kostin, S. Dammer, S. Hein, W.P. Klovekorn, E.P. Bauer and J. Schaper: Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovasc Res, 62, 426-36 (2004) (Pubitemid 38496555)
43. H. Kitamura, Y. Ohnishi, A. Yoshida, K. Okajima, H. Azumi, A. Ishida, E.J. Galeano, S. Kubo, Y. Hayashi, H. Itoh and M. Yokoyama: Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. J Cardiovasc Electrophysiol, 13, 865-70 (2002)
44. K.A. Yamada, J.G. Rogers, R. Sundset, T.H. Steinberg and J.E. Saffitz: Up-regulation of connexin45 in heart failure. J Cardiovasc Electrophysiol, 14, 1205-12 (2003) (Pubitemid 37452891)
45. P. Cowin, H.P. Kapprell, W.W. Franke, J. Tamkun and R.O. Hynes: Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell, 46, 1063-73 (1986) (Pubitemid 17182730)
46. C. Bierkamp, K.J. McLaughlin, H. Schwarz, O. Huber and R. Kemler: Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol, 180, 780-5 (1996) (Pubitemid 27037381)
47. P. Ruiz, V. Brinkmann, B. Ledermann, M. Behrend, C. Grund, C. Thalhammer, F. Vogel, C. Birchmeier, U. Gunthert, W.W. Franke and W. Birchmeier: Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol, 135, 215-25 (1996) (Pubitemid 26337749)
48. K.S. Grossmann, C. Grund, J. Huelsken, M. Behrend, B. Erdmann, W.W. Franke and W. Birchmeier: Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol, 167, 149-60 (2004) (Pubitemid 39363422)
49. J. Zhurinsky, M. Shtutman and A. Ben-Ze'ev: Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. J Cell Sci, 113 ( Pt 18), 3127-39 (2000)
50. J. Zhurinsky, M. Shtutman and A. Ben-Ze'ev: Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol, 20, 4238-52 (2000) (Pubitemid 30346619)
51. M.W. Klymkowsky, B.O. Williams, G.D. Barish, H.E. Varmus and Y.E. Vourgourakis: Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Mol Biol Cell, 10, 3151-69 (1999) (Pubitemid 29489552)
52. J. Li, D. Swope, N. Raess, L. Cheng, E.J. Muller and G.L. Radice: Cardiac-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol, 31, 1134-44 (2011)
53. R. Lombardi, J. Dong, G. Rodriguez, A. Bell, T.K. Leung, R.J. Schwartz, J.T. Willerson, R. Brugada and A.J. Marian: Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res, 104, 1076-84 (2009)
54. G. McKoy, N. Protonotarios, A. Crosby, A. Tsatsopoulou, A. Anastasakis, A. Coonar, M. Norman, C. Baboonian, S. Jeffery and W.J. McKenna: Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). Lancet, 355, 2119-24 (2000) (Pubitemid 30364661)
55. A. Asimaki, P. Syrris, T. Wichter, P. Matthias, J.E. Saffitz and W.J. McKenna: A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet, 81, 964-73 (2007) (Pubitemid 47580249)
56. B. Gerull, A. Heuser, T. Wichter, M. Paul, C.T. Basson, D.A. McDermott, B.B. Lerman, S.M. Markowitz, P.T. Ellinor, C.A. MacRae, S. Peters, K.S. Grossmann, J. Drenckhahn, B. Michely, S. Sasse-Klaassen, W. Birchmeier, R. Dietz, G. Breithardt, E. Schulze-Bahr and L. Thierfelder: Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet, 36, 1162-4 (2004) (Pubitemid 41288964)
57. J.P. van Tintelen, M.M. Entius, Z.A. Bhuiyan, R. Jongbloed, A.C. Wiesfeld, A.A. Wilde, J. van der Smagt, L.G. Boven, M.M. Mannens, I.M. van Langen, R.M. Hofstra, L.C. Otterspoor, P.A. Doevendans, L.M. Rodriguez, I.C. van Gelder and R.N. Hauer: Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circulation, 113, 1650-8 (2006)
58. S. Pieperhoff, H. Schumacher and W.W. Franke: The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNAmediated knockdown in cultured rat cardiomyocytes. Eur J Cell Biol, 87, 399-411 (2008)
59. E.M. Oxford, H. Musa, K. Maass, W. Coombs, S.M. Taffet and M. Delmar: Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Circ Res, 101, 703-11 (2007) (Pubitemid 47494101)
60. C. Mertens, C. Kuhn and W.W. Franke: Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. J Cell Biol, 135, 1009-25 (1996) (Pubitemid 26403775)
61. X. Chen, S. Bonne, M. Hatzfeld, F. van Roy and K.J. Green: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. J Biol Chem, 277, 10512-22 (2002) (Pubitemid 34968174)
62. S. Goossens, B. Janssens, S. Bonne, R. De Rycke, F. Braet, J. van Hengel and F. van Roy: A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. J Cell Sci, 120, 2126-36 (2007) (Pubitemid 47010007)
63. M.A. van der Heyden, M.B. Rook, M.M. Hermans, G. Rijksen, J. Boonstra, L.H. Defize and O.H. Destree: Identification of connexin43 as a functional target for Wnt signalling. J Cell Sci, 111 ( Pt 12), 1741-9 (1998) (Pubitemid 28330560)
64. Z. Ai, A. Fischer, D.C. Spray, A.M. Brown and G.I. Fishman: Wnt-1 regulation of connexin43 in cardiac myocytes. J Clin Invest, 105, 161-71 (2000) (Pubitemid 30054355)
65. M. Hatzfeld, K.J. Green and H. Sauter: Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. J Cell Sci, 116, 1219-33 (2003) (Pubitemid 36410661)
66. C.C. Calkins, B.L. Hoepner, C.M. Law, M.R. Novak, S.V. Setzer, M. Hatzfeld and A.P. Kowalczyk: The Armadillo family protein p0071 is a VE-cadherin-and desmoplakinbinding protein. J Biol Chem, 278, 1774-83 (2003) (Pubitemid 36801413)
67. M. Hatzfeld and C. Nachtsheim: Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J Cell Sci, 109 ( Pt 11), 2767-78 (1996) (Pubitemid 26388361)
68. M. Hatzfeld: The p120 family of cell adhesion molecules. Eur J Cell Biol, 84, 205-14 (2005) (Pubitemid 40353062)
69. R. Keil, A. Wolf, S. Huttelmaier and M. Hatzfeld: Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle, 6, 122-7 (2007) (Pubitemid 46232487)
70. M. Kanno, Y. Aoyama, Y. Isa, Y. Yamamoto and Y. Kitajima: P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells. J Dermatol, 35, 317-24 (2008) (Pubitemid 351840233)
71. M. Kanno, Y. Isa, Y. Aoyama, Y. Yamamoto, M. Nagai, M. Ozawa and Y. Kitajima: P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3. Exp Cell Res, 314, 1683-92 (2008)
72. S. Bonne, B. Gilbert, M. Hatzfeld, X. Chen, K.J. Green and F. van Roy: Defining desmosomal plakophilin-3 interactions. J Cell Biol, 161, 403-16 (2003) (Pubitemid 36529857)
73. N.K. Noren, B.P. Liu, K. Burridge and B. Kreft: p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol, 150, 567-80 (2000)
74. N.K. Noren, C.M. Niessen, B.M. Gumbiner and K. Burridge: Cadherin engagement regulates Rho family GTPases. J Biol Chem, 276, 33305-8 (2001)
75. W. Meng, Y. Mushika, T. Ichii and M. Takeichi: Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell, 135, 948-59 (2008)
76. B.R. Stevenson, J.D. Siliciano, M.S. Mooseker and D.A. Goodenough: Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol, 103, 755-66 (1986) (Pubitemid 17177325)
77. R.J. Barker, R.L. Price and R.G. Gourdie: Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions. Circ Res, 90, 317-24 (2002) (Pubitemid 34638847)
78. T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori and M. Tada: Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J Biol Chem, 273, 12725-31 (1998) (Pubitemid 28246824)
79. M. Itoh, A. Nagafuchi, S. Moroi and S. Tsukita: Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol, 138, 181-92 (1997) (Pubitemid 27337462)
80. B.N. Giepmans: Gap junctions and connexin-interacting proteins. Cardiovasc Res, 62, 233-45 (2004) (Pubitemid 38496537)
81. B.N. Giepmans and W.H. Moolenaar: The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein. Curr Biol, 8, 931-4 (1998) (Pubitemid 28371760)
82. R.M. Shaw, A.J. Fay, M.A. Puthenveedu, M. von Zastrow, Y.N. Jan and L.Y. Jan: Microtubule plus-endtracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell, 128, 547-60 (2007) (Pubitemid 46198893)
83. C.J. Wei, R. Francis, X. Xu and C.W. Lo: Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells. J Biol Chem, 280, 19925-36 (2005) (Pubitemid 41379521)
84. J.C. Wu, R.Y. Tsai and T.H. Chung: Role of catenins in the development of gap junctions in rat cardiomyocytes. J Cell Biochem, 88, 823-35 (2003)
85. J.A. Palatinus and R.G. Gourdie: Xin and the art of intercalated disk maintenance. Am J Physiol Heart Circ Physiol, 293, H2626-8 (2007) (Pubitemid 350106487)
86. A.W. Hunter, R.J. Barker, C. Zhu and R.G. Gourdie: Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell, 16, 5686-98 (2005) (Pubitemid 41752218)
87. J.M. Rhett, J. Jourdan and R.G. Gourdie: Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1. Mol Biol Cell, 22, 1516-28 (2011)
88. K. Maass, J. Shibayama, S.E. Chase, K. Willecke and M. Delmar: C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ Res, 101, 1283-91 (2007) (Pubitemid 350294645)
89. S. Choi, E.A. Gustafson-Wagner, Q. Wang, S.M. Harlan, H.W. Sinn, J.L. Lin and J.J. Lin: The intercalated disc protein, mXinα, is capable of interacting with β-catenin and bundling actin filaments. J Biol Chem, 282, 36024-36 (2007) (Pubitemid 350277145)
90. S. Balasubramanian, S.K. Mani, H. Kasiganesan, C.C. Baicu and D. Kuppuswamy: Hypertrophic stimulation increases beta-actin dynamics in adult feline cardiomyocytes. PLoS ONE, 5, e11470 (2010)
91. S.M. Manisastry, K.J. Zaal and R. Horowits: Myofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes. Exp Cell Res, 315, 2126-39 (2009)
92. J.Q. Zhang, B. Elzey, G. Williams, S. Lu, D.J. Law and R. Horowits: Ultrastructural and biochemical localization of NRAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry, 40, 14898-906 (2001) (Pubitemid 33136111)
93. M. Yoshida, E. Sho, H. Nanjo, M. Takahashi, M. Kobayashi, K. Kawamura, M. Honma, M. Komatsu, A. Sugita, M. Yamauchi, T. Hosoi, Y. Ito and H. Masuda: Weaving hypothesis of cardiomyocyte sarcomeres: discovery of periodic broadening and narrowing of intercalated disk during volume-load change. Am J Pathol, 176, 660-78 (2010)
94. A.E. Bass-Zubek, L.M. Godsel, M. Delmar and K.J. Green: Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol, 21, 708-16 (2009)
95. W.J. Nelson and R. Nusse: Convergence of Wnt, β-catenin, and cadherin pathways. Science, 303, 1483-87 (2004) (Pubitemid 38314410)
96. M. Perez-Moreno and E. Fuchs: Catenins: keeping cells from getting their signals crossed. Dev Cell, 11, 601-12 (2006) (Pubitemid 44644972)
97. A.V. Kwiatkowski, W.I. Weis and W.J. Nelson: Catenins: playing both sides of the synapse. Curr Opin Cell Biol, 19, 551-6 (2007) (Pubitemid 350016851)
98. J. Heuberger and W. Birchmeier: Interplay of cadherinmediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol, 2, a002915 (2010)
99. X. Chen, S.P. Shevtsov, E. Hsich, L. Cui, S. Haq, M. Aronovitz, R. Kerkela, J.D. Molkentin, R. Liao, R.N. Salomon, R. Patten and T. Force: The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol, 26, 4462-73 (2006) (Pubitemid 43877567)
100. A. Hirschy, A. Croquelois, E. Perriard, R. Schoenauer, I. Agarkova, S.P. Hoerstrup, M.M. Taketo, T. Pedrazzini, J.C. Perriard and E. Ehler: Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death. Basic Res Cardiol, 105, 597-608 (2010)
101. M.C. Ferreira-Cornwell, Y. Luo, N. Narula, J.M. Lenox, M. Lieberman and G.L. Radice: Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart. Journal of Cell Science, 115, 1623-34 (2002) (Pubitemid 34520592)
102. I. Kostetskii, J. Li, Y. Xiong, R. Zhou, V.A. Ferrari, V.V. Patel, J.D. Molkentin and G.L. Radice: Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res, 96, 346-54 (2005) (Pubitemid 40279909)
103. J. Li, V.V. Patel, I. Kostetskii, Y. Xiong, A.F. Chu, J.T. Jacobson, C. Yu, G.E. Morley, J.D. Molkentin and G.L. Radice: Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res, 97, 474-81 (2005) (Pubitemid 41298178)
104. J. Li, M.D. Levin, Y. Xiong, N. Petrenko, V.V. Patel and G.L. Radice: N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility. J Mol Cell Cardiol, 44, 597-606 (2008)
105. R. Arulanandam, A. Vultur, J. Cao, E. Carefoot, B.E. Elliott, P.F. Truesdell, L. Larue, H. Feracci and L. Raptis: Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3. Mol Cancer Res, 7, 1310-27 (2009)
106. L. Raptis, R. Arulanandam, A. Vultur, M. Geletu, S. Chevalier and H. Feracci: Beyond structure, to survival: activation of Stat3 by cadherin engagement. Biochem Cell Biol, 87, 835-43 (2009)
107. T. Watanabe, K. Sato and K. Kaibuchi: Cadherinmediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol, 1, a003020 (2009)
108. S. Yonemura, Y. Wada, T. Watanabe, A. Nagafuchi and M. Shibata: alpha-Catenin as a tension transducer that induces adherens junction development. Nat Cell Biol, 12, 533-42 (2010)
109. Q. le Duc, Q. Shi, I. Blonk, A. Sonnenberg, N. Wang, D. Leckband and J. de Rooij: Vinculin potentiates Ecadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol, 189, 1107-15 (2010)
110. M. Smutny and A.S. Yap: Neighborly relations: cadherins and mechanotransduction. J Cell Biol, 189, 1075-7 (2010)
111. A.T. Naito, I. Shiojima, H. Akazawa, K. Hidaka, T. Morisaki, A. Kikuchi and I. Komuro: Developmental stagespecific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci U S A, 103, 19812-7 (2006) (Pubitemid 46037513)
112. S. Ueno, G. Weidinger, T. Osugi, A.D. Kohn, J.L. Golob, L. Pabon, H. Reinecke, R.T. Moon and C.E. Murry: Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A, 104, 9685-90 (2007) (Pubitemid 47175327)
113. M.J. Marvin, G. di Rocco, A. Gardiner, S.M. Bush and A.B. Lassar: Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes & Dev, 15, 316-27 (2001) (Pubitemid 32155147)
114. E. Tzahor and A.B. Lassar: Wnt signals from the neural tube block ectopic cardiogenesis. Genes & Dev, 15, 255-60 (2001) (Pubitemid 32155141)
115. D. Ai, X. Fu, J. Wang, M.F. Lu, L. Chen, A. Baldini, W.H. Klein and J.F. Martin: Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A, 104, 9319-24 (2007) (Pubitemid 47185777)
116. E.D. Cohen, Z. Wang, J.J. Lepore, M.M. Lu, M.M. Taketo, D.J. Epstein and E.E. Morrisey: Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest, 117, 1794-804 (2007) (Pubitemid 47036313)
117. A. Klaus, Y. Saga, M.M. Taketo, E. Tzahor and W. Birchmeier: Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A, 104, 18531-6 (2007) (Pubitemid 350210731)
118. M. Buckingham, S. Meilhac and S. Zaffran: Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet, 6, 826-35 (2005)
119. D. Srivastava: Making or breaking the heart: from lineage determination to morphogenesis. Cell, 126, 1037-48 (2006) (Pubitemid 44380303)
120. S. Haq, A. Michael, M. Andreucci, K. Bhattacharya, P. Dotto, B. Walters, J. Woodgett, H. Kilter and T. Force: Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A, 100, 4610-5 (2003) (Pubitemid 36457778)
121. T. Force, K. Woulfe, W.J. Koch and R. Kerkela: Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane- domain receptor signaling pathways. Sci STKE, 2007, pe41 (2007)
122. J. Qu, J. Zhou, X.P. Yi, B. Dong, H. Zheng, L.M. Miller, X. Wang, M.D. Schneider and F. Li: Cardiacspecific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction. J Mol Cell Cardiol, 43, 319-26 (2007) (Pubitemid 47304446)
123. V.A. van de Schans, S.W. van den Borne, A.E. Strzelecka, B.J. Janssen, J.L. van der Velden, R.C. Langen, A. Wynshaw-Boris, J.F. Smits and W.M. Blankesteijn: Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy. Hypertension, 49, 473-80 (2007)
124. P. Malekar, M. Hagenmueller, A. Anyanwu, S. Buss, M.R. Streit, C.S. Weiss, D. Wolf, J. Riffel, A. Bauer, H.A. Katus and S.E. Hardt: Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling. Hypertension, 55, 939-45 (2010)
125. A. Baurand, L. Zelarayan, R. Betney, C. Gehrke, S. Dunger, C. Noack, A. Busjahn, J. Huelsken, M.M. Taketo, W. Birchmeier, R. Dietz and M.W. Bergmann: Betacatenin downregulation is required for adaptive cardiac remodeling. Circ Res, 100, 1353-62 (2007) (Pubitemid 46742926)
126. J. Zhou, J. Qu, X.P. Yi, K. Graber, L. Huber, X. Wang, A.M. Gerdes and F. Li: Upregulation of gammacatenin compensates for the loss of beta-catenin in adult cardiomyocytes. Am J Physiol Heart Circ Physiol, 292, H270-6 (2007) (Pubitemid 46115923)
127. L. Masuelli, R. Bei, P. Sacchetti, I. Scappaticci, P. Francalanci, L. Albonici, A. Coletti, C. Palumbo, M. Minieri, R. Fiaccavento, F. Carotenuto, C. Fantini, L. Carosella, A. Modesti and P. Di Nardo: β-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts. Cardiovasc Res, 60, 376-87 (2003) (Pubitemid 37412371)
128. S. Chen, D.C. Guttridge, Z. You, Z. Zhang, A. Fribley, M.W. Mayo, J. Kitajewski and C.Y. Wang: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol, 152, 87-96 (2001) (Pubitemid 32102439)
129. K.A. Longo, J.A. Kennell, M.J. Ochocinska, S.E. Ross, W.S. Wright and O.A. MacDougald: Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem, 277, 38239-44 (2002) (Pubitemid 35154678)
130. S.E. Ross, N. Hemati, K.A. Longo, C.N. Bennett, P.C. Lucas, R.L. Erickson and O.A. MacDougald: Inhibition of adipogenesis by Wnt signaling. Science, 289, 950-3 (2000) (Pubitemid 30659947)
131. K. Pilichou, C.A. Remme, C. Basso, M.E. Campian, S. Rizzo, P. Barnett, B.P. Scicluna, B. Bauce, M.J. van den Hoff, J.M. de Bakker, H.L. Tan, M. Valente, A. Nava, A.A. Wilde, A.F. Moorman, G. Thiene and C.R. Bezzina: Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy. J Exp Med, 206, 1787-802 (2009)
132. J.P. Kucera, S. Rohr and Y. Rudy: Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res, 91, 1176-82 (2002) (Pubitemid 36076367)
133. S.K. Maier, R.E. Westenbroek, K.A. McCormick, R. Curtis, T. Scheuer and W.A. Catterall: Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation, 109, 1421-7 (2004) (Pubitemid 38387830)
134. S.K. Maier, R.E. Westenbroek, K.A. Schenkman, E.O. Feigl, T. Scheuer and W.A. Catterall: An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A, 99, 4073-8 (2002) (Pubitemid 34252231)
135. P.J. Mohler, I. Splawski, C. Napolitano, G. Bottelli, L. Sharpe, K. Timothy, S.G. Priori, M.T. Keating and V. Bennett: A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci U S A, 101, 9137-42 (2004) (Pubitemid 38781624)
136. S.A. Cohen: Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disks. Circulation, 94, 3083-6 (1996) (Pubitemid 26427470)
137. J.D. Malhotra, V. Thyagarajan, C. Chen and L.L. Isom: Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J Biol Chem, 279, 40748-54 (2004) (Pubitemid 39287670)
138. L.S. Meadows and L.L. Isom: Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovasc Res, 67, 448-58 (2005) (Pubitemid 41019552)
139. P.Y. Sato, H. Musa, W. Coombs, G. Guerrero-Serna, G.A. Patino, S.M. Taffet, L.L. Isom and M. Delmar: Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res, 105, 523-6 (2009)
140. F.C. Chan, C.P. Cheng, K.H. Wu, Y.C. Chen, C.H. Hsu, E.A. Gustafson-Wagner, J.L. Lin, Q. Wang, J.J. Lin and C.I. Lin: Intercalated disc-associated protein, mXin alpha, influences surface expression of ITO currents in ventricular myocytes. Front Biosci (Elite Ed), 3, 1425-42 (2011)
141. J.T. Butcher and R.R. Markwald: Valvulogenesis: the moving target. Philos Trans R Soc Lond B Biol Sci, 362, 1489-503 (2007) (Pubitemid 47195036)
142. L.M. Eisenberg and R.R. Markwald: Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ Res, 77, 1-6 (1995)
143. R.R. Markwald, R.A. Norris, R. Moreno-Rodriguez and R.A. Levine: Developmental basis of adult cardiovascular diseases: valvular heart diseases. Ann N Y Acad Sci, 1188, 177-83 (2010)
144. J. Otten, P.F. van der Ven, P. Vakeel, S. Eulitz, G. Kirfel, O. Brandau, M. Boesl, J.W. Schrickel, M. Linhart, K. Hayess, F.J. Naya, H. Milting, R. Meyer and D.O. Furst: Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. Cardiovasc Res, 85, 739-50 (2010)
145. J.J.-C. Lin, E.A. Gustafson-Wagner, H.W. Sinn, S. Choi, S.M. Jaacks, D.Z. Wang, S. Evans and J.L.-C. Lin: Structure, expression, and function of a novel intercalated disc protein, Xin. J Med Sci, 25, 215-22 (2005) (Pubitemid 41502500)
146. D. Pacholsky, P. Vakeel, M. Himmel, T. Lowe, T. Stradal, K. Rottner, D.O. Furst and P.F.M. van der Ven: Xin repeats define a novel actin-binding motif. J Cell Sci, 117, 5257-68 (2004) (Pubitemid 39562488)
147. H.T. Huang, O.M. Brand, M. Mathew, C. Ignatiou, E.P. Ewen, S.A. McCalmon and F.J. Naya: Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein. J Biol Chem, 281, 39370-9 (2006) (Pubitemid 46041896)
148. H.W. Sinn, J. Balsamo, J. Lilien and J.J. Lin: Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn, 225, 1-13 (2002) (Pubitemid 34983143)
149. P.F.M. van der Ven, E. Ehler, P. Vakeel, S. Eulitz, J.A. Schenk, H. Milting, B. Micheel and D.O. Furst: Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mens/VASP. Exp Cell Res, 312, 2154-67 (2006) (Pubitemid 43850938)
150. D.G. Edmondson, G.E. Lyons, J.F. Martin and E.N. Olson: Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development, 120, 1251-63 (1994) (Pubitemid 24150050)
151. T.J. Lints, L.M. Parsons, L. Hartley, I. Lyons and R.P. Harvey: Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development, 119, 969 (1993) (Pubitemid 23337435)
152. I. Lyons, L.M. Parsons, L. Hartley, R. Li, J.E. Andrews, L. Robb and R.P. Harvey: Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev, 9, 1654-66 (1995)
153. Q. Lin, J. Schwarz, C. Bucana and E.N. Olson: Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science, 276, 1404-7 (1997) (Pubitemid 27235406)
154. S.A. McCalmon, D.M. Desjardins, S. Ahmad, K.S. Davidoff, C.M. Snyder, K. Sato, K. Ohashi, O.M. Kielbasa, M. Mathew, E.P. Ewen, K. Walsh, H. Gavras and F.J. Naya: Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2. Circ Res, 106, 952-60 (2010)
155. R. Hirakow and T. Gotoh: Ontogenetic implication of the myocardial ultrastructure in the development of mammalian heart. In R. van Praagh and A. Takao (eds.), Etiology and morphogenesis of congenital heart disease, Futura Publishing Co., Mount Kisco, NY, (1980), pp. 99-108.
156. Y.Q. Zhou, F.S. Foster, R. Parkes and S.L. Adamson: Developmental changes in left and right ventricular diastolic filling patterns in mice. Am J Physiol Heart Circ Physiol, 285, H1563-75 (2003) (Pubitemid 37169511)
157. J.A. Hill, M. Karimi, W. Kutschke, R.L. Davisson, K. Zimmerman, Z. Wang, R.E. Kerber and R.M. Weiss: Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation, 101, 2863-9 (2000) (Pubitemid 30396019)
158. H.A. Rockman, K.U. Knowlton, J. J. Ross and K.R. Chien: In vivo murine cardiac hypertrophy. Circulation, 87[suppl VII], VII14-VII21 (1993)
159. H.A. Rockman, R.S. Ross, A.N. Harris, K.U. Knowlton, M.E. Steinhelper, L.J. Field, J. Ross, Jr. and K.R. Chien: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A, 88, 8277-81 (1991) (Pubitemid 21915339)
160. A. Duka, F. Schwartz, I. Duka, C. Johns, E. Melista, I. Gavras and H. Gavras: A novel gene (Cmya3) induced in the heart by angiotensin II-dependent but not saltdependent hypertension in mice. Am J Hypertens, 19, 275-81 (2006) (Pubitemid 43261508)
161. A. Rambaut. SE-AL sequence alignment program. Version 1.D1, Department of Zoology, University of Oxford, Oxford, England, 1995.
162. J.D. Thompson, D.G. Higgins and T.J. Gibson: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignments through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research, 22, 4673-80 (1994) (Pubitemid 24354800)
163. F. Abascal, R. Zardoya and D. Posada: ProtTest: selection of best-fit models of protein evolution. Bioinformatics, 21, 2104-5 (2005) (Pubitemid 40668057)
164. S. Guindon and O. Gascuel: A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol, 52, 696-704 (2003) (Pubitemid 37365050)
165. A. Stamatakis, T. Ludwig and H. Meier: RAxML-III: a fast program for maximum likelihood-based inference of large phylogenetic trees. Bioinformatics, 21, 456-63 (2005) (Pubitemid 40310232)
166. M.J. Legato: Cellular mechanisms of normal growth in the mammalian heart. I. Qualitative and quantitative features of ventricular architecture in the dog from birth to five months of age. Circ Res, 44, 250-62 (1979) (Pubitemid 9120521)
167. B.D. Angst, L.U. Khan, N.J. Severs, K. Whitely, S. Rothery, R.P. Thompson, A.I. Magee and R.G. Gourdie: Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Circ Res, 80, 88-94 (1997) (Pubitemid 27030373)
168. A. Hirschy, F. Schatzmann, E. Ehler and J.C. Perriard: Establishment of cardiac cytoarchitecture in the developing mouse heart. Dev Biol, 289, 430-41 (2006) (Pubitemid 43049945)
169. N.S. Peters, N.J. Severs, S.M. Rothery, C. Lincoln, M.H. Yacoub and C.R. Green: Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium. Circulation, 90, 713-25 (1994) (Pubitemid 24242737)
170. H.M. Eppenberger and C. Zuppinger: In vitro reestablishment of cell-cell contacts in adult rat cardiomyocytes. Functional role of transmembrane components in the formation of new intercalated disk-like cell contacts. Faseb J, 13 Suppl, S83-9 (1999)
171. C.M. Hertig, S. Butz, S. Koch, M. Eppenberger-Eberhardt, R. Kemler and H.M. Eppenberger: N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct Ncadherin/ catenin complexes. J Cell Sci, 109 ( Pt 1), 11-20 (1996) (Pubitemid 26037923)
172. C.M. Hertig, M. Eppenberger-Eberhardt, S. Koch and H.M. Eppenberger: N-cadherin in adult rat cardiomyocytes in culture. I. Functional role of N-cadherin and impairment of cell-cell contact by a truncated N-cadherin mutant. J Cell Sci, 109 ( Pt 1), 1-10 (1996) (Pubitemid 26037922)
173. A. Kusumi, K. Suzuki and K. Koyasako: Mobility and cytoskeletal interactions of cell adhesion receptors. Curr Opin Cell Biol, 11, 582-90 (1999) (Pubitemid 29460399)
174. A.S. Yap, C.M. Niessen and B.M. Gumbiner: The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J Cell Biol, 141, 779-89 (1998) (Pubitemid 28217921)
175. S. Hong, R.B. Troyanovsky and S.M. Troyanovsky: Spontaneous assembly and active disassembly balance adherens junction homeostasis. Proc Natl Acad Sci U S A, 107, 3528-33 (2010)
176. R.B. Troyanovsky, O. Laur and S.M. Troyanovsky: Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion. Mol Biol Cell, 18, 4343-52 (2007) (Pubitemid 350060163)
177. T.D. Perez, M. Tamada, M.P. Sheetz and W.J. Nelson: Immediate-early signaling induced by E-cadherin engagement and adhesion. J Biol Chem, 283, 5014-22 (2008)
178. K.J. Green, S. Getsios, S. Troyanovsky and L.M. Godsel: Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol, 2, a000125 (2010)
179. S. de Beco, C. Gueudry, F. Amblard and S. Coscoy: Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc Natl Acad Sci U S A, 106, 7010-5 (2009)
180. A.K. Classen, K.I. Anderson, E. Marois and S. Eaton: Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell, 9, 805-17 (2005) (Pubitemid 41724108)
181. J.G. Lock and J.L. Stow: Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Mol Biol Cell, 16, 1744-55 (2005) (Pubitemid 40471945)
182. K. Xiao, R.G. Oas, C.M. Chiasson and A.P. Kowalczyk: Role of p120-catenin in cadherin trafficking. Biochim Biophys Acta, 1773, 8-16 (2007) (Pubitemid 44914097)
183. F. Drees, S. Pokutta, S. Yamada, W.J. Nelson and W.I. Weis: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell, 123, 903-15 (2005) (Pubitemid 41721035)
184. S. Yamada, S. Pokutta, F. Drees, W.I. Weis and W.J. Nelson: Deconstructing the cadherin-catenin-actin complex. Cell, 123, 889-901 (2005) (Pubitemid 41721034)
185. M. Cavey and T. Lecuit: Molecular bases of cell-cell junctions stability and dynamics. Cold Spring Harb Perspect Biol, 1, a002998 (2009)
186. M. Cavey, M. Rauzi, P.F. Lenne and T. Lecuit: A twotiered mechanism for stabilization and immobilization of Ecadherin. Nature, 453, 751-6 (2008) (Pubitemid 351793782)
187. K. Abe and M. Takeichi: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A, 105, 13-9 (2008)
188. S. Yamada and W.J. Nelson: Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol, 178, 517-27 (2007) (Pubitemid 47196158)
189. M.R. Kooistra, N. Dube and J.L. Bos: Rap1: a key regulator in cell-cell junction formation. J Cell Sci, 120, 17-22 (2007) (Pubitemid 46206645)
190. W.J. Pannekoek, M.R. Kooistra, F.J. Zwartkruis and J.L. Bos: Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors. Biochim Biophys Acta, 1788, 790-6 (2009)
191. S. Somekawa, S. Fukuhara, Y. Nakaoka, H. Fujita, Y. Saito and N. Mochizuki: Enhanced functional gap junction neoformation by protein kinase A-dependent and Epacdependent signals downstream of cAMP in cardiac myocytes. Circ Res, 97, 655-62 (2005) (Pubitemid 41416334)
192. H.M. Phillips, H.J. Rhee, J.N. Murdoch, V. Hildreth, J.D. Peat, R.H. Anderson, A.J. Copp, B. Chaudhry and D.J. Henderson: Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circ Res, 101, 137-45 (2007) (Pubitemid 47196581)
193. T. Matsuda, K. Takahashi, T. Nariai, T. Ito, T. Takatani, Y. Fujio and J. Azuma: N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes. Biochem Biophys Res Commun, 326, 228-32 (2005) (Pubitemid 39573223)
194. A. Salameh, A. Wustmann, S. Karl, K. Blanke, D. Apel, D. Rojas-Gomez, H. Franke, F.W. Mohr, J. Janousek and S. Dhein: Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43. Circ Res, 106, 1592-602 (2010)
195. M. Yamane, T. Matsuda, T. Ito, Y. Fujio, K. Takahashi and J. Azuma: Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress. Biochem Biophys Res Commun, 353, 1023-7 (2007) (Pubitemid 46080399)
196. J.K. Wahl, 3rd, Y.J. Kim, J.M. Cullen, K.R. Johnson and M.J. Wheelock: N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem, 278, 17269-76 (2003) (Pubitemid 36799609)
197. C.P. Cheng, Y.X. Loh, C.I. Lin, Y.J. Lai, Y.C. Chen, H.K. Sytwn, E.A. Gustafson-Wagner and J.J.-C. Lin: Electrophysiological characteristics of ventricular myocytes of Xinα-deficient mice. In A. Kimchi (ed.), International Proceedings: Advances in heart disease, MEDIMOND, Bologna, Italy, (2005), pp. 25-29.
198. Y.J. Lai, Y.Y. Chen, C.P. Cheng, J.J. Lin, S.L. Chudorodova, I.M. Roshchevskaya, M.P. Roshchevsky, Y.C. Chen and C.I. Lin: Changes in ionic currents and reduced conduction velocity in hypertrophied ventricular myocardium of Xinα-deficient mice. Anatol J Cardiol, 7 Suppl 1, 90-2 (2007) (Pubitemid 47033762)
199. Y.J. Lai, E.Y. Huang, H.I. Yeh, Y.L. Chen, J.J. Lin and C.I. Lin: On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrialpulmonary veins. Life Sci, 83, 272-83 (2008)
200. W. Guo, H. Li, F. Aimond, D.C. Johns, K.J. Rhodes, J.S. Trimmer and J.M. Nerbonne: Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ Res, 90, 586-93 (2002) (Pubitemid 34640909)
201. J.M. Nerbonne and R.S. Kass: Molecular physiology of cardiac repolarization. Physiol Rev, 85, 1205-53 (2005) (Pubitemid 41362269)
202. P.J. Mohler, I. Rivolta, C. Napolitano, G. LeMaillet, S. Lambert, S.G. Priori and V. Bennett: Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci U S A, 101, 17533-8 (2004) (Pubitemid 39657438)
203. S.C. Eijsbouts, R.P. Houben, Y. Blaauw, U. Schotten and M.A. Allessie: Synergistic action of atrial dilation and sodium channel blockade on conduction in rabbit atria. J Cardiovasc Electrophysiol, 15, 1453-61 (2004) (Pubitemid 40013680)
204. E. Ehler, R. Horowits, C. Zuppinger, R.L. Price, E. Perriard, M. Leu, P. Caroni, M. Sussman, H.M. Eppenberger and J.C. Perriard: Alterations at the intercalated disk associated with the absence of muscle LIM protein. J Cell Biol, 153, 763-72 (2001) (Pubitemid 34286108)
205. Y. Fujio, F. Yamada-Honda, N. Sato, H. Funai, A. Wada, N. Awata and N. Shibata: Disruption of cell-cell adhesion in an inbred strain of hereditary cardiomyopathic hamster (Bio 14.6). Cardiovasc Res, 30, 899-904 (1995)
206. S. Kostin, G. Klein, Z. Szalay, S. Hein, E.P. Bauer and J. Schaper: Structural correlate of atrial fibrillation in human patients. Cardiovasc Res, 54, 361-79 (2002) (Pubitemid 34327915)
207. X. Wang and A.M. Gerdes: Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. intercalated disc remodeling. J Mol Cell Cardiol, 31, 333-43 (1999) (Pubitemid 29089882)
208. T.M. Olson and M.T. Keating: Mapping a cardiomyopathy locus to chromosome 3p22-p25. J Clin Invest, 97, 528-32 (1996) (Pubitemid 26039420)
209. F. Ahmad, D. Li, A. Karibe, O. Gonzalez, T. Tapscott, R. Hill, D. Weilbaecher, P. Blackie, M. Furey, M. Gardner, L. Bachinski and R. Roberts: Localization of a gene responsible for arrhythmogenic right ventricular dysplasia to chromosome 3p23. Circulation, 98, 2791-95 (1998) (Pubitemid 29003957)
210. D. Levy, G.B. Ehret, K. Rice, G.C. Verwoert, L.J. Launer, A. Dehghan, N.L. Glazer, A.C. Morrison, A.D. Johnson, T. Aspelund, Y. Aulchenko, T. Lumley, A. Kottgen, R.S. Vasan, F. Rivadeneira, G. Eiriksdottir, X. Guo, D.E. Arking, G.F. Mitchell, F.U. Mattace-Raso, A.V. Smith, K. Taylor, R.B. Scharpf, S.J. Hwang, E.J. Sijbrands, J. Bis, T.B. Harris, S.K. Ganesh, C.J. O'Donnell, A. Hofman, J.I. Rotter, J. Coresh, E.J. Benjamin, A.G. Uitterlinden, G. Heiss, C.S. Fox, J.C. Witteman, E. Boerwinkle, T.J. Wang, V. Gudnason, M.G. Larson, A. Chakravarti, B.M. Psaty and C.M. van Duijn: Genome-wide association study of blood pressure and hypertension. Nat Genet, 41, 677-87 (2009)
211. M. Jung, I. Poepping, A. Perrot, A.E. Ellmer, T.F. Wienker, R. Dietz, A. Reis and K.J. Osterziel: Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22. Am J Hum Genet, 65, 1068-77 (1999) (Pubitemid 30462964)
212. A. Rampazzo, A. Nava, M. Miorin, P. Fonderico, B. Pope, N. Tiso, B. Livolsi, R. Zimbello, G. Thiene and G.A. Danieli: ARVD4, a new locus for arrhythmogrnic right ventricular cardiomyopathy, maps to chromosome 2 long arm. Genomics, 45, 259-63 (1997) (Pubitemid 27467614)
213. B. Kalmyrzaev, A. Aldashev, M. Khalmatov, A. Polupanov, A. Jumagulova, L. Mamanova, M.R. Wilkins and M. Town: Genome-wide scan for premature hypertension supports linkage to chromosome 2 in a large Kyrgyz family. Hypertension, 48, 908-13 (2006) (Pubitemid 44611004)