Structure, expression, and function of a novel intercalated disc protein, Xin

Journal of Medical Sciences

Volumn 25, Issue 5, 2005, Pages 215-222

  Lin, Jim Jung Ching ^a   Gustafson Wagner, Elisabeth A ^a   Sinn, Haley W ^a   Choi, Sunju ^a   Jaacks, Shannon M ^a   Wang, Da Zhi ^b   Evans, Sylvia ^c   Lin, Jenny Li Chun ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

catenin binding protein; Cardiomyopathy; Intercalated disc; Nkx2.5; Xin repeats

Indexed keywords

BETA CATENIN; COMPLEMENTARY DNA; NERVE CELL ADHESION MOLECULE; PROTEIN; PROTEIN XIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CHICKEN; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DNA BINDING; DOWNSTREAM PROCESSING; EMBRYO DEVELOPMENT; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GENE MAPPING; HEART DEVELOPMENT; HEART FUNCTION; MOLECULAR CLONING; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

EID: 27144519302     PISSN: 10114564     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Srivastava D, Olson EN. A genetic blueprint for cardiac development. Nature 2000;407:221-226.
2. Chien KR, Olson EN. Converging pathways and principles in heart development and disease: CV@CSH. Cell 2002;110:153-162.
3. Olson EN, Schneider MD. Sizing up the heart: developmental redux in disease. Genes Dev 2003;17:1937-1956.
4. Bruneau BG. The developing heart and congenital heart defects: a make or break situation. Clin Genet 2003;63:252-261.
5. Olson EN. A decade of discoveries in cardiac biology. Nat Med 2004;10:467-474.
6. Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG. Congenital heart disease caused by mutations in the transcription factor Nkx2-5. Science 1998;281:108-111.
7. Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD. Mutations in the cardiac transcription factor Nkx2.5 affect diverse cardiac developmental pathways. J Clin Invest 1999;104:1567-1573.
8. Goldmuntz E, Geiger E, Benson DW. Nkx2.5 mutations in patients with tetralogy of fallot. Circulation 2001;104:2565-2568.
9. Gutierrez-Roelens I, Sluysmans T, Gewillig M, Devriendt K, Vikkula M. Progressive AV-block and anomalous venous return among cardiac anomalies associated with two novel missense mutations in the Csx/Nkx2-5 gene. Hum Mutat 2002;20:75-76.
10. Elliott DA, Kirk EP, Yeoh T, Chandar S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley M, Harvey RP. Cardiac homeobox gene Nkx2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J Am Coll Cardiol 2003;41:2072-2076.
11. Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 2004;117:373-386.
12. Wang DZ, Hu X, Lin JL-C, Kitten GT, Solursh M, Lin JJ-C. Differential displaying of mRNAs from the atrioventricular region of developing chicken hearts at stages 15 and 21. Front Biosci 1996;1:1-15.
13. Wang DZ, Reiter RS, Lin JL-C, Wang Q, Williams HS, Krob SL, Schultheiss TM, Evans S, Lin JJ-C. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development 1999;126:1281-1294.
14. Wang DZ, Sheffield VC, Lin JJ-C. Mapping of the human homologue of mouse Xinα by radiation hybrid ananlysis. unpublished data 1998.
15. Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF. Xin repeats define a novel actin-binding motif. J Cell Sci 2004; 117:5257-5268.
16. Sinn HW, Balsamo J, Lilien J, Lin JJ-C. Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn 2002;225:1-13.
17. Lin JJ-C, Wang DZ, Reiter RS, Wang Q, Lin JL-C, Williams HS. Differentially expressed genes and cardiac morphogenesis. In: Tomanek RJ, Runyan R, eds. Formation of the Heart and Its Regulation. Boston, MA: Birkhauser, 2001:75-96.
18. Schultheiss TM, Burch JB, Lassar AB. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 1997;11:451-462.
19. Nelson WJ, Nusse R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 2004;303:1483-1487.
20. Polakis P. Casein kinase 1: a Wnt'er of disconnect. Curr Biol 2002;12:R499-R501.
21. Schneider VA, Mercola M. Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev 2001;15: 304-315.
22. Lickert H, Kutsch S, Kanzler B, Tamai Y, Taketo MM, Kemler R. Formation of multiple hearts in mice following deletion of b-catenin in the embryonic endoderm. Dev Cell 2002;3:171-181.
23. Ferreira-Cornwell MC, Luo Y, Narula N, Lenox JM, Lieberman M, Radice GL. Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart. J Cell Sci 2002;115: 1623-1634.
24. Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, Molkentin JD, Radice GL. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 2005;96:346-354.
25. Lilien J, Balsamo J, Arregui C, Xu G. Turn-off, dropout: functional state switching of cadherins. Dev Dyn 2002;224:18-29.
26. Hill JA, Karimi M, Kutschke W, Davisson RL, Zimmerman K, Wang Z, Kerber RE, Weiss RM. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation 2000;101: 2863-2869.
27. Rockman HA, Knowlton KU, Ross J Jr, Chien KR. In vivo murine cardiac hypertrophy: a novel model to identify genetic signaling mechanisms that activate an adaptive physiological response. Circulation 1993;87 (Suppl):VII14-VII21.
28. Friddle CJ, Koga T, Rubin EM, Bristow J. Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci 2000;97:6745-6750.
29. Tachibana K, Nakanishi H, Mandai K, Ozaki K, Ikeda W, Yamamoto Y, Nagafuchi A, Tsukita S, Takai Y. Two cell adhesion molecules, nectin and cadherin, interact through their cytoplsmic domain-associated proteins. J Cell Biol 2000;150:1161-1176.
30. Pokutta S, Drees F, Takai Y, Nelson WJ, Weis WI. Biochemical and structural definition of the 1-afadin-and actin-binding sites of α-catenin. J Biol Chem 2002;277:18868-18874.