Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress

Biochemical and Biophysical Research Communications

Volumn 353, Issue 4, 2007, Pages 1023-1027

  Yamane, Masako ^a   Matsuda, Takahisa ^a   Ito, Takashi ^a   Fujio, Yasushi ^a   Takahashi, Kyoko ^a   Azuma, Junichi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Cardiac myocytes; Cell alignment; Mechanical stretch; Rac1; RhoA

Indexed keywords

ADENOVIRUS VECTOR; RAC1 PROTEIN; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SILICON;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ALIGNMENT; CELL CULTURE; CELL GROWTH; CELL POLARITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEART MUSCLE CELL; IN VITRO STUDY; MECHANICAL STRESS; MUSCLE STRETCHING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PULL DOWN ASSAY; RAT; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELL POLARITY; CELL SHAPE; CELLS, CULTURED; GENETIC VECTORS; MICROSCOPY, FLUORESCENCE; MUTATION; MYOCYTES, CARDIAC; PROTEIN BINDING; RAC1 GTP-BINDING PROTEIN; RATS; RATS, INBRED WKY; RHOA GTP-BINDING PROTEIN; STRESS, MECHANICAL; TRANSFECTION;

ADENOVIRIDAE; RATTUS;

EID: 33846146986     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.12.144     Document Type: Article

References (21)

1. Sadoshima J., Jahn L., Takahashi T., Kulik T.J., and Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J. Biol. Chem. 267 (1992) 10551-10560
2. Ruwhof C., and van der Laarse A. Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc. Res. 47 (2000) 23-37
3. Matsuda T., Takahashi K., Nariai T., Ito T., Takatani T., Fujio Y., and Azuma J. N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes. Biochem. Biophys. Res. Commun. 326 (2005) 228-232
4. Sepp R., Severs N.J., and Gourdie R.G. Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy. Heart 76 (1996) 412-417
5. Marian A.J., Wu Y., Lim D.S., McCluggage M., Youker K., Yu Q.T., Brugada R., DeMayo F., Quinones M., and Roberts R. A transgenic rabbit model for human hypertrophic cardiomyopathy. J. Clin. Invest. 104 (1999) 1683-1692
6. Wolf C.M., Moskowitz I.P., Arno S., Branco D.M., Semsarian C., Bernstein S.A., Peterson M., Maida M., Morley G.E., Fishman G., Berul C.I., Seidman C.E., and Seidman J.G. Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proc. Natl. Acad. Sci. USA 102 (2005) 18123-18128
7. Aikawa R., Komuro I., Yamazaki T., Zou Y., Kudoh S., Zhu W., Kadowaki T., and Yazaki Y. Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circ. Res. 84 (1999) 458-466
8. Satoh M., Ogita H., Takeshita K., Mukai Y., Kwiatkowski D.J., and Liao J.K. Requirement of Rac1 in the development of cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 103 (2006) 7432-7437
9. Nagai T., Tanaka-Ishikawa M., Aikawa R., Ishihara H., Zhu W., Yazaki Y., Nagai R., and Komuro I. Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes. Biochem. Biophys. Res. Commun. 305 (2003) 806-810
10. Kaunas R., Nguyen P., Usami S., and Chien S. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc. Natl. Acad. Sci. USA 102 (2005) 15895-15900
11. Matsuda T., Fujio Y., Nariai T., Ito T., Yamane M., Takatani T., Takahashi K., and Azuma J. N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. J. Mol. Cell Cardiol. 40 (2006) 495-502
12. Kiyono M., Satoh T., and Kaziro Y. G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm). Proc. Natl. Acad. Sci. USA 96 (1999) 4826-4831
13. Noren N.K., Liu B.P., Burridge K., and Kreft B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150 (2000) 567-580
14. Yoshizaki H., Ohba Y., Kurokawa K., Itoh R.E., Nakamura T., Mochizuki N., Nagashima K., and Matsuda M. Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J. Cell Biol. 162 (2003) 223-232
15. Nakagawa M., Fukata M., Yamaga M., Itoh N., and Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell Sci. 114 (2001) 1829-1838
16. Heineke J., and Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7 (2006) 589-600
17. Sah V.P., Minamisawa S., Tam S.P., Wu T.H., Dorn II G.W., Ross Jr. J., Chien K.R., and Brown J.H. Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J. Clin. Invest. 103 (1999) 1627-1634
18. Nobes C.D., and Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81 (1995) 53-62
19. Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., and Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70 (1992) 401-410
20. Tzima E., Del Pozo M.A., Kiosses W.B., Mohamed S.A., Li S., Chien S., and Schwartz M.A. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J. 21 (2002) 6791-6800
21. Aikawa R., Nagai T., Kudoh S., Zou Y., Tanaka M., Tamura M., Akazawa H., Takano H., Nagai R., and Komuro I. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension 39 (2002) 233-238