Changes in ionic currents and reduced conduction velocity in hypertrophied ventricular myocardium of Xinα-deficient mice

Anadolu Kardiyoloji Dergisi

Volumn 7, Issue SUPPL. 1, 2007, Pages 90-92

  Lai, Yu Jun ^a,b   Chen, Ya Yu ^a   Cheng, Chio Pei ^a   Lin, Jim Jung Ching ^c   Chudorodova, Svetlana L ^d   Roshchevskaya, Irina M ^d   Roshchevsky, Mikhail P ^d   Chen, Yao Chang ^a   Lin, Cheng I ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c UNIVERSITY OF IOWA   (United States)

^d INSTITUTE OF BIOLOGY   (Russian Federation)

Author keywords

Arrhythmia; Conduction velocity; Ionic currents; Temperature; Voltage clamp studies; Xin deficient murine heart

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART PACING; HEART REPOLARIZATION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE HYPERTROPHY; HYPOTHERMIA; ISOLATED HEART; MOUSE; NONHUMAN; PATCH CLAMP; REENTRY ARRHYTHMIA; SODIUM CURRENT; TACHYCARDIA; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; DNA-BINDING PROTEINS; HYPERTROPHY, LEFT VENTRICULAR; ION CHANNELS; MALE; MICE; MICE, INBRED STRAINS; MUSCLE CELLS; MYOCARDIUM; NUCLEAR PROTEINS; PATCH-CLAMP TECHNIQUES;

EID: 34447122132     PISSN: 13028723     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. Wang DZ, Reiter RS, Lin JL, Wang Q, Williams HS, Krob SL, et al. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development 1999; 126: 1281-94.
2. Gustafson-Wagner EA, Lin JLC, Sinn H, Wang DZ, Reiter RS, Yang B, et al. Targeted deletion of mXinα gene, encoding an intercalated disc protein, leads to cardiac hypertrophy (Abstract). AHA Scientific Sessions 2006; 2006 Nov 12-15; Chicago, IL, USA; Circulation 2006; 114 (Suppl): II-54.
3. Cheng CP, Loh YX, Lin CI, Lai YJ, Chen YC, Sytwu HK, et al. Electrophysiological characteristics of ventricular myocytes of Xinα-deficient mice. In: Kimchi A, editor. Advances in Heart Disease. Proceedings of the 12th World Congress on Heart Disease; 2005 July 16-19; Vancouver, Canada; s.r.l. Bolongna, Italy; MEDI-MOND: 2005. p. 25-9.
4. Bers DM. Cardiac excitation-contraction coupling. Nature 2002; 415: 198-205.
5. Wu SH, Chen YC, Higa S, Lin CI. Oscillatory transient inward currents in ventricular myocytes of healthy versus myopathic Syrian hamster. Clin Exp Pharmacol Physiol 2004; 31: 668-76.
6. Chen YJ, Chen SA, Chen YC, Yeh HI, Chang P, Chang MS, et al. Rapid atrial pacing increases the arrhythmogenic activity of single cardiomyocytes from pulmonary veins: implication in initiation of atrial fibrillation. Circulation 2001; 104: 2849-54.
7. Chen YJ, Chen SA, Chen YC, Yeh HI, Chang MS, Lin CI. Electrophysiology of single cardiomyocytes isolated from rabbit pulmonary veins: implication in initiation of focal atrial fibrillation. Basic Res Cardiol 2002; 97: 26-34.
8. Baker LC, London B, Choi BR, Koren G, Salama G. Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circ Res 2000; 86: 396-407.
9. Pashmforoush M, Lu JT, Chen H, St. Amand T, Kondo R, Pradervand S, et al. Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 2004; 117: 373-86.
10. Hamburger F. Myopathy of hamster dystrophy: history and morphologic aspects. Ann NY Acad Sci 1979; 317: 1-7.
11. Roshchevsky MP, Chudorodova SL, Shmakov DN, Roshchevskaya IM. The cardioelectric field on the pig body surface during initial atrial activity. Doklady Biol Sci 2005; 402: 561-2.