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Volumn 31, Issue 17, 2012, Pages 2199-2209

E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts

Author keywords

cellular senescence; E6AP; p53; Ras; stress

Indexed keywords

PROTEIN E6AP; PROTEIN P53; RAS PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 84860274471     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.402     Document Type: Article
Times cited : (20)

References (56)
  • 1
    • 0037068461 scopus 로고    scopus 로고
    • Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    • Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE. et al. (2002). Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419: 162-167.
    • (2002) Nature , vol.419 , pp. 162-167
    • Bardeesy, N.1    Sinha, M.2    Hezel, A.F.3    Signoretti, S.4    Hathaway, N.A.5    Sharpless, N.E.6
  • 2
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N. et al. (2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444: 633-637.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3    Karakaidos, P.4    Kletsas, D.5    Issaeva, N.6
  • 3
    • 54249105821 scopus 로고    scopus 로고
    • HPV E6, E6AP and cervical cancer
    • Beaudenon S, Huibregtse JM. (2008). HPV E6, E6AP and cervical cancer. BMC Biochem 9(Suppl 1): S4.
    • (2008) BMC Biochem. , vol.9 , Issue.SUPPL. 1
    • Beaudenon, S.1    Huibregtse, J.M.2
  • 4
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase rna
    • Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA. et al. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3    Samper, E.4    Lansdorp, P.M.5    DePinho, R.A.6
  • 5
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. (2005). Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120: 513-522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 6
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J, d'Adda di Fagagna F. (2007). Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    D'adda Di Fagagna, F.2
  • 7
    • 33644859083 scopus 로고    scopus 로고
    • The ubiquitin proteolytic system: From a vague idea, through basic mechanisms, and onto human diseases and drug targeting
    • Ciechanover A. (2006). The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology 66: S7-19.
    • (2006) Neurology , vol.66
    • Ciechanover, A.1
  • 8
    • 33745712849 scopus 로고    scopus 로고
    • The power and the promise of oncogene-induced senescence markers
    • Collado M, Serrano M. (2006). The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 6: 472-476.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 472-476
    • Collado, M.1    Serrano, M.2
  • 9
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • Collado M, Serrano M. (2010). Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 10: 51-57.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 10
    • 0033635597 scopus 로고    scopus 로고
    • Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
    • Dannenberg JH, van Rossum A, Schuijff Lte Riele H. (2000). Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev 14: 3051-3064.
    • (2000) Genes Dev. , vol.14 , pp. 3051-3064
    • Dannenberg, J.H.1    Van Rossum, A.2    Schuijff Lte Riele, H.3
  • 11
    • 56449090138 scopus 로고    scopus 로고
    • DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization
    • Di Micco R, Cicalese A, Fumagalli M, Dobreva M, Verrecchia A, Pelicci PG. et al. (2008). DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization. Cell Cycle 7: 3601-3606.
    • (2008) Cell Cycle , vol.7 , pp. 3601-3606
    • Di Micco, R.1    Cicalese, A.2    Fumagalli, M.3    Dobreva, M.4    Verrecchia, A.5    Pelicci, P.G.6
  • 12
    • 36048965126 scopus 로고    scopus 로고
    • Breaking news: High-speed race ends in arrest-how oncogenes induce senescence
    • Di Micco R, Fumagalli M, d'Adda di Fagagna F. (2007). Breaking news: high-speed race ends in arrest-how oncogenes induce senescence. Trends Cell Biol 17: 529-536.
    • (2007) Trends Cell Biol. , vol.17 , pp. 529-536
    • Di Micco, R.1    Fumagalli, M.2    D'adda Di Fagagna, F.3
  • 13
    • 20444370974 scopus 로고    scopus 로고
    • What has senescence got to do with cancer
    • Dimri GP. (2005). What has senescence got to do with cancer? Cancer Cell 7: 505-512.
    • (2005) Cancer Cell , vol.7 , pp. 505-512
    • Dimri, G.P.1
  • 16
    • 0033634973 scopus 로고    scopus 로고
    • DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    • Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C. et al. (2000). DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002.
    • (2000) Mol. Cell , vol.5 , pp. 993-1002
    • Frank, K.M.1    Sharpless, N.E.2    Gao, Y.3    Sekiguchi, J.M.4    Ferguson, D.O.5    Zhu, C.6
  • 17
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • Gil J, Peters G. (2006). Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 7: 667-677.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 18
    • 40449120350 scopus 로고    scopus 로고
    • An oncogeneinduced DNA damage model for cancer development
    • Halazonetis TD, Gorgoulis VG, Bartek J. (2008). An oncogeneinduced DNA damage model for cancer development. Science 319: 1352-1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 21
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt Y, Barak Y, Oren M. (1996). Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 15: 1596-1606.
    • (1996) EMBO J. , vol.15 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 22
    • 63449111028 scopus 로고    scopus 로고
    • Warts, cancer and ubiquitylation: Lessons from the papillomaviruses
    • discussion 126-117
    • Howley PM. (2006). Warts, cancer and ubiquitylation: lessons from the papillomaviruses. Trans Am Clin Climatol Assoc 117: 113-126; discussion 126-117.
    • (2006) Trans Am. Clin. Climatol. Assoc. , vol.117 , pp. 113-126
    • Howley, P.M.1
  • 23
    • 0025932933 scopus 로고
    • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
    • Huibregtse JM, Scheffner M, Howley PM. (1991). A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J 10: 4129-4135.
    • (1991) EMBO J. , vol.10 , pp. 4129-4135
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 25
    • 0032192481 scopus 로고    scopus 로고
    • Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation
    • Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G. et al. (1998b). Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21: 799-811.
    • (1998) Neuron , vol.21 , pp. 799-811
    • Jiang, Y.H.1    Armstrong, D.2    Albrecht, U.3    Atkins, C.M.4    Noebels, J.L.5    Eichele, G.6
  • 26
    • 33344469819 scopus 로고    scopus 로고
    • Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland
    • Khan OY, Fu G, Ismail A, Srinivasan S, Cao X, Tu Y. et al. (2006 Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol 20: 544-559.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 544-559
    • Khan, O.Y.1    Fu, G.2    Ismail, A.3    Srinivasan, S.4    Cao, X.5    Tu, Y.6
  • 27
    • 33746616991 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
    • Kortlever RM, Higgins PJ, Bernards R. (2006). Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8: 877-884.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 877-884
    • Kortlever, R.M.1    Higgins, P.J.2    Bernards, R.3
  • 30
    • 0034633702 scopus 로고    scopus 로고
    • Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
    • Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, Oren M. (2000). Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci USA 97: 11250-11255.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11250-11255
    • Lev Bar-Or, R.1    Maya, R.2    Segel, L.A.3    Alon, U.4    Levine, A.J.5    Oren, M.6
  • 31
    • 2942618208 scopus 로고    scopus 로고
    • Pathogenesis of human papillomaviruses in differentiating epithelia
    • Longworth MS, Laimins LA. (2004). Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68: 362-372.
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 362-372
    • Longworth, M.S.1    Laimins, L.A.2
  • 34
    • 53849136261 scopus 로고    scopus 로고
    • Ubiquitin ligase E6-AP and its role in human disease
    • Matentzoglu K, Scheffner M. (2008). Ubiquitin ligase E6-AP and its role in human disease. Biochem Soc Trans 36: 797-801.
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 797-801
    • Matentzoglu, K.1    Scheffner, M.2
  • 35
    • 0031031570 scopus 로고    scopus 로고
    • De novo truncating mutations in E6-AP ubiquitinprotein ligase gene (UBE3A) in Angelman syndrome
    • Matsuura T, Sutcliffe JS, Fang P, Galjaard RJ, Jiang YH, Benton CS. et al. (1997). De novo truncating mutations in E6-AP ubiquitinprotein ligase gene (UBE3A) in Angelman syndrome. Nat Genet 15: 74-77.
    • (1997) Nat. Genet. , vol.15 , pp. 74-77
    • Matsuura, T.1    Sutcliffe, J.S.2    Fang, P.3    Galjaard, R.J.4    Jiang, Y.H.5    Benton, C.S.6
  • 36
    • 69749085632 scopus 로고    scopus 로고
    • UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27
    • Mishra A, Godavarthi SK, Jana NR. (2009). UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27. Neurobiol Dis 36: 26-34.
    • (2009) Neurobiol. Dis. , vol.36 , pp. 26-34
    • Mishra, A.1    Godavarthi, S.K.2    Jana, N.R.3
  • 37
    • 39749139563 scopus 로고    scopus 로고
    • Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome
    • Mishra A, Jana NR. (2008). Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome. Cell Mol Life Sci 65: 656-666.
    • (2008) Cell Mol. Life Sci. , vol.65 , pp. 656-666
    • Mishra, A.1    Jana, N.R.2
  • 38
    • 0029559374 scopus 로고
    • Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts
    • Mu XC, Higgins PJ. (1995). Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts. J Cell Physiol 165: 647-657.
    • (1995) J. Cell Physiol. , vol.165 , pp. 647-657
    • Mu, X.C.1    Higgins, P.J.2
  • 39
    • 33846706172 scopus 로고    scopus 로고
    • P53: At the crossroad between cancer and ageing
    • Papazoglu C, Mills AA. (2007). p53: at the crossroad between cancer and ageing. J Pathol 211: 124-133.
    • (2007) J. Pathol. , vol.211 , pp. 124-133
    • Papazoglu, C.1    Mills, A.A.2
  • 41
    • 38048999665 scopus 로고    scopus 로고
    • Two faces of p53: Aging and tumor suppression
    • Rodier F, Campisi J, Bhaumik D. (2007). Two faces of p53: aging and tumor suppression. Nucleic Acids Res 35: 7475-7484.
    • (2007) Nucleic. Acids. Res. , vol.35 , pp. 7475-7484
    • Rodier, F.1    Campisi, J.2    Bhaumik, D.3
  • 42
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signallingtriggers senescence-associated inflammatory cytokine secretion
    • Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR. et al. (2009). Persistent DNA damage signallingtriggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 11: 973-979.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1    Coppe, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Munoz, D.P.5    Raza, S.R.6
  • 43
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T. (2003). Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424: 223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 44
    • 0033637086 scopus 로고    scopus 로고
    • Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
    • Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B. et al. (2000). Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev 14: 3037-3050.
    • (2000) Genes Dev. , vol.14 , pp. 3037-3050
    • Sage, J.1    Mulligan, G.J.2    Attardi, L.D.3    Miller, A.4    Chen, S.5    Williams, B.6
  • 45
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. (1993). The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75: 495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 46
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. (1990). The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 47
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 48
    • 34447530408 scopus 로고    scopus 로고
    • Molecular chaperones regulate p53 and suppress senescence programs
    • Sherman MY, Gabai V, O'Callaghan C, Yaglom J. (2007). Molecular chaperones regulate p53 and suppress senescence programs. FEBS Lett 581: 3711-3715.
    • (2007) FEBS Lett. , vol.581 , pp. 3711-3715
    • Sherman, M.Y.1    Gabai, V.2    O'Callaghan, C.3    Yaglom, J.4
  • 49
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock
    • Sherr CJ, DePinho RA. (2000). Cellular senescence: mitotic clock or culture shock? Cell 102: 407-410.
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 51
    • 0032513114 scopus 로고    scopus 로고
    • The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)- positive and HPV-negative cells
    • Talis AL, Huibregtse JM, Howley PM. (1998). The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)- positive and HPV-negative cells. J Biol Chem 273: 6439-6445.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6439-6445
    • Talis, A.L.1    Huibregtse, J.M.2    Howley, P.M.3
  • 52
    • 84883840386 scopus 로고
    • Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
    • Todaro GJ, Green H. (1963). Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 17: 299-313.
    • (1963) J. Cell Biol. , vol.17 , pp. 299-313
    • Todaro, G.J.1    Green, H.2
  • 54
    • 67650432153 scopus 로고    scopus 로고
    • RUNX1 and its fusion oncoprotein derivative, RUNX1- ETO, induce senescence-like growth arrest independently of replicative stress
    • Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G. et al. (2009). RUNX1 and its fusion oncoprotein derivative, RUNX1- ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene 28: 2502-2512.
    • (2009) Oncogene , vol.28 , pp. 2502-2512
    • Wolyniec, K.1    Wotton, S.2    Kilbey, A.3    Jenkins, A.4    Terry, A.5    Peters, G.6
  • 55
    • 68849093989 scopus 로고    scopus 로고
    • Tumour suppression by p53: The importance of apoptosis and cellular senescence
    • Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y. (2009). Tumour suppression by p53: the importance of apoptosis and cellular senescence. J Pathol 219: 3-15.
    • (2009) J. Pathol. , vol.219 , pp. 3-15
    • Zuckerman, V.1    Wolyniec, K.2    Sionov, R.V.3    Haupt, S.4    Haupt, Y.5
  • 56
    • 0031743608 scopus 로고    scopus 로고
    • Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L. et al. (1998). Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 72: 9873-9880.
    • (1998) J. Virol. , vol.72 , pp. 9873-9880
    • Zufferey, R.1    Dull, T.2    Mandel, R.J.3    Bukovsky, A.4    Quiroz, D.5    Naldini, L.6


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