RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress

Oncogene

Volumn 28, Issue 27, 2009, Pages 2502-2512

  Wolyniec, K ^a   Wotton, S ^a   Kilbey, A ^a   Jenkins, A ^a   Terry, A ^a   Peters, G ^b   Stocking, C ^c   Cameron, E ^a   Neil, J C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

Premature senescence; RUNX1; RUNX1 ETO

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; ONCOPROTEIN; PROTEIN P53; PROTEIN RUNX1 ETO; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL DIVISION; CELL GROWTH; CELL STRESS; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; SENESCENCE; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FIBROBLASTS; FORESKIN; HUMANS; INFANT, NEWBORN; MALE; MUTATION; ONCOGENE PROTEINS, FUSION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RAS PROTEINS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE;

EID: 67650432153     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.101     Document Type: Article

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