메뉴 건너뛰기




Volumn 3, Issue 8, 2012, Pages 1017-1023

Computer simulations of voltage-gated cation channels

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHANNELS; COMPUTATIONAL POWER; COMPUTATIONAL STUDIES; COMPUTATIONAL WORK; GATING MECHANISMS; ION CHANNEL; ION CONDUCTION; MEMBRANE LIPIDS; MEMBRANE PROTEIN STRUCTURES; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATIONS; POTASSIUM CHANNELS; SODIUM CHANNEL;

EID: 84860180058     PISSN: None     EISSN: 19487185     Source Type: Journal    
DOI: 10.1021/jz300089g     Document Type: Review
Times cited : (15)

References (66)
  • 3
    • 16244365169 scopus 로고    scopus 로고
    • The voltage-sensor structure in a voltage-gated channel
    • DOI 10.1016/j.tibs.2005.02.006
    • Bezanilla, F. The Voltage-Sensor Structure in a Voltage-Gated Ion Channel Trends Biochem. Sci. 2005, 30, 166-168 (Pubitemid 40463303)
    • (2005) Trends in Biochemical Sciences , vol.30 , Issue.4 , pp. 166-168
    • Bezanilla, F.1
  • 4
    • 77956996917 scopus 로고    scopus 로고
    • Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology
    • Catterall, W. A. Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology Neuron 2010, 67, 915-928
    • (2010) Neuron , vol.67 , pp. 915-928
    • Catterall, W.A.1
  • 5
    • 0032823307 scopus 로고    scopus 로고
    • Voltage-gated ion channels and hereditary disease
    • Lehmann-Horn, F.; Jurkat-Rott, K. Voltage-Gated Ion Channels and Hereditary Disease Physiol. Rev. 1999, 79, 1317-1372 (Pubitemid 29473318)
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1317-1372
    • Lehmann-Horn, F.1    Jurkat-Rott, K.2
  • 7
    • 79960621367 scopus 로고    scopus 로고
    • The Crystal Structure of a Voltage-Gated Sodium Channel
    • Payandeh, J.; Scheuer, T.; Zheng, N.; Catterall, W. A. The Crystal Structure of a Voltage-Gated Sodium Channel Nature 2011, 475, 353-358
    • (2011) Nature , vol.475 , pp. 353-358
    • Payandeh, J.1    Scheuer, T.2    Zheng, N.3    Catterall, W.A.4
  • 8
    • 79958211512 scopus 로고    scopus 로고
    • Backbone and Side Chain Dynamics Evaluated by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Experiments. I: Molecular Dynamics Simulations
    • Ingólfsson, H. I.; Li, Y.; Vostrikov, V. V.; Gu, H.; Hinton, J. F.; Koeppe, R. E.; Roux, B.; Andersen, O. S.; Gramicidin, A. Backbone and Side Chain Dynamics Evaluated by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Experiments. I: Molecular Dynamics Simulations J. Phys. Chem. B 2011, 115, 7417-7426
    • (2011) J. Phys. Chem. B , vol.115 , pp. 7417-7426
    • Ingólfsson, H.I.1    Li, Y.2    Vostrikov, V.V.3    Gu, H.4    Hinton, J.F.5    Koeppe, R.E.6    Roux, B.7    Andersen, O.S.8    Gramicidin, A.9
  • 9
    • 0042213113 scopus 로고    scopus 로고
    • + channel in a bilayer membrane
    • + Channel in a Bilayer Membrane Biophys. J. 2000, 78, 2900-2917 (Pubitemid 30396923)
    • (2000) Biophysical Journal , vol.78 , Issue.6 , pp. 2900-2917
    • Berneche, S.1    Roux, B.2
  • 10
    • 0034036372 scopus 로고    scopus 로고
    • Simulations of ion permeation through a potassium channel: Molecular dynamics of KcsA in a phospholipid bilayer
    • Shrivastava, I. H.; Sansom, M. S. P. Simulations of Ion Permeation Through a Potassium Channel: Molecular Dynamics of KcsA in a Phospholipid Bilayer Biophys. J. 2000, 78, 557-570 (Pubitemid 30211816)
    • (2000) Biophysical Journal , vol.78 , Issue.2 , pp. 557-570
    • Shrivastava, I.H.1    Sansom, M.S.P.2
  • 11
    • 0034690250 scopus 로고    scopus 로고
    • Ion permeation mechanism of the potassium channel
    • DOI 10.1038/35009114
    • Åqvist, J.; Luzhkov, V. Ion Permeation Mechanism of the Potassium Channel Nature 2000, 404, 881-884 (Pubitemid 30230340)
    • (2000) Nature , vol.404 , Issue.6780 , pp. 881-884
    • Aqvist, J.1    Luzhkov, V.2
  • 12
  • 15
    • 0038009204 scopus 로고    scopus 로고
    • Potassium Channel, Ions, and Water: Simulation Studies Based on the High Resolution X-Ray Structure of KcsA
    • Domene, C.; Sansom, M. S. P. Potassium Channel, Ions, and Water: Simulation Studies Based on the High Resolution X-ray Structure of KcsA Biophys. J. 2003, 85, 2787-2800 (Pubitemid 37345773)
    • (2003) Biophysical Journal , vol.85 , Issue.5 , pp. 2787-2800
    • Domene, C.1    Sansom, M.S.P.2
  • 16
    • 0037071785 scopus 로고    scopus 로고
    • Potassium permeation through the KcsA channel: A density functional study
    • DOI 10.1016/S0005-2736(02)00349-8, PII S0005273602003498
    • Guidoni, L.; Carloni, P. Potassium Permeation Through the KcsA Channel: A Density Functional Study Biochim. Biophys. Acta 2002, 1563, 1-6 (Pubitemid 34455036)
    • (2002) Biochimica et Biophysica Acta - Biomembranes , vol.1563 , Issue.1-2 , pp. 1-6
    • Guidoni, L.1    Carloni, P.2
  • 18
    • 33751229926 scopus 로고    scopus 로고
    • Conduction in the Selectivity Filter of Potassium Channels Is Monitored by the Charge Distribution along Their Sequence
    • Treptow, W.; Tarek, M. K. Conduction in the Selectivity Filter of Potassium Channels Is Monitored by the Charge Distribution along Their Sequence Biophys. J. 2006, 91, L81-83
    • (2006) Biophys. J. , vol.91 , pp. 81-83
    • Treptow, W.1    Tarek, M.K.2
  • 19
    • 8844228899 scopus 로고    scopus 로고
    • Not ions alone: Barriers to ion permeation in nanopores and channels
    • DOI 10.1021/ja045271e
    • Beckstein, O.; Tai, K.; Sansom, M. S. Not Ions Alone: Barriers to Ion Permeation in Nanopores and Channels J. Am. Chem. Soc. 2004, 126, 14694-14695 (Pubitemid 39532132)
    • (2004) Journal of the American Chemical Society , vol.126 , Issue.45 , pp. 14694-14695
    • Beckstein, O.1    Tai, K.2    Sansom, M.S.P.3
  • 20
    • 33746725967 scopus 로고    scopus 로고
    • Molecular Restraints in the Permeation Pathway of Ion Channels
    • Treptow, W.; Tarek, M. Molecular Restraints in the Permeation Pathway of Ion Channels Biophys. J. 2006, 91, L26-L28
    • (2006) Biophys. J. , vol.91
    • Treptow, W.1    Tarek, M.2
  • 22
    • 17844406709 scopus 로고    scopus 로고
    • The α7 nicotinic acetylcholine receptor: Molecular modelling, electrostatics, and energetics
    • DOI 10.1080/09687860500063340
    • Amiri, S.; Beckstein, O.; Biggin, P. C.; Sansom, M. S. The Alpha7 Nicotinic Acetylcholine Receptor: Molecular Modelling, Electrostatic and Energetics Mol. Membr. Biol. 2005, 22, 151-162 (Pubitemid 41020332)
    • (2005) Molecular Membrane Biology , vol.22 , Issue.3 , pp. 151-162
    • Amiri, S.1    Tai, K.2    Beckstein, O.3    Biggin, P.C.4    Sansom, M.S.P.5
  • 24
    • 13544256698 scopus 로고    scopus 로고
    • Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS
    • DOI 10.1529/biophysj.104.046045
    • Sotomayor, M.; Schulten, K. Molecular Dynamics Study of Gating in the Mechanosensitive Channel of Small Conductance MscS Biophys. J. 2004, 87, 3050-3065 (Pubitemid 40468564)
    • (2004) Biophysical Journal , vol.87 , Issue.5 , pp. 3050-3065
    • Sotomayor, M.1    Schulten, K.2
  • 25
    • 17044400911 scopus 로고    scopus 로고
    • Gate in the Selectivity Filter of Potassium Channels
    • Bernèche, S.; Roux, B. A. Gate in the Selectivity Filter of Potassium Channels Structure 2005, 13, 591-600
    • (2005) Structure , vol.13 , pp. 591-600
    • Bernèche, S.1    Roux, B.A.2
  • 27
    • 33646135082 scopus 로고    scopus 로고
    • Environment of the Gating Charges in the Kv1.2 Shaker Potassium Channel
    • Treptow, W.; Tarek, M. Environment of the Gating Charges in the Kv1.2 Shaker Potassium Channel Biophys. J. 2006, 90, L64-66
    • (2006) Biophys. J. , vol.90 , pp. 64-66
    • Treptow, W.1    Tarek, M.2
  • 28
    • 34547628129 scopus 로고    scopus 로고
    • + channel in a membrane environment
    • DOI 10.1529/biophysj.107.112540
    • + Channel in a Membrane Environment Biophys. J. 2007, 93, 3070-3082 (Pubitemid 350097098)
    • (2007) Biophysical Journal , vol.93 , Issue.9 , pp. 3070-3082
    • Jogini, V.1    Roux, B.2
  • 30
    • 50349088433 scopus 로고    scopus 로고
    • Molecular Dynamics Simulation of Kv Channel Voltage Sensor Helix in a Lipid Membrane with Applied Electric Field
    • Nishizawa, M.; Nishizawa, K. Molecular Dynamics Simulation of Kv Channel Voltage Sensor Helix in a Lipid Membrane with Applied Electric Field Biophys. J. 2008, 95, 1729-1744
    • (2008) Biophys. J. , vol.95 , pp. 1729-1744
    • Nishizawa, M.1    Nishizawa, K.2
  • 31
    • 61449172924 scopus 로고    scopus 로고
    • Conformational Changes and Slow Dynamics Through Microsecond Polarized Atomistic Molecular Simulation of an Integral Kv1.2 Ion Channel
    • Bjelkmar, P.; Niemelä, P. S.; Vattulainen, I.; Lindahl, E. Conformational Changes and Slow Dynamics Through Microsecond Polarized Atomistic Molecular Simulation of an Integral Kv1.2 Ion Channel PLoS Comput Biol. 2009, 5, e1000289
    • (2009) PLoS Comput Biol. , vol.5 , pp. 1000289
    • Bjelkmar, P.1    Niemelä, P.S.2    Vattulainen, I.3    Lindahl, E.4
  • 32
    • 67849095786 scopus 로고    scopus 로고
    • Initial Response of the Potassium Channel Voltage Sensor to a Transmembrane Potential
    • Treptow, W.; Tarek, M.; Klein, M. L. Initial Response of the Potassium Channel Voltage Sensor to a Transmembrane Potential J.Am. Chem. Soc. 2009, 131, 2107-2109
    • (2009) J.Am. Chem. Soc. , vol.131 , pp. 2107-2109
    • Treptow, W.1    Tarek, M.2    Klein, M.L.3
  • 33
    • 70350787095 scopus 로고    scopus 로고
    • From the Gating Charge Response to Pore Domain Movement: Initial Motions of Kv1.2 Dynamics under Physiological Voltage Changes
    • Denning, E. J.; Crozier, P. S.; Sachs, J. N.; Woolf, T. B. From the Gating Charge Response to Pore Domain Movement: Initial Motions of Kv1.2 Dynamics Under Physiological Voltage Changes Mol Membr Biol. 2009, 26, 397-421
    • (2009) Mol Membr Biol. , vol.26 , pp. 397-421
    • Denning, E.J.1    Crozier, P.S.2    Sachs, J.N.3    Woolf, T.B.4
  • 34
    • 79954991393 scopus 로고    scopus 로고
    • Intermediate States of the Kv1.2 Voltage Sensor from Atomistic Molecular Dynamics Simulations
    • Delemotte, L.; Tarek, M.; Klein, M. L.; Amaral, C.; Treptow, W. Intermediate States of the Kv1.2 Voltage Sensor from Atomistic Molecular Dynamics Simulations Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6109-6114
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 6109-6114
    • Delemotte, L.1    Tarek, M.2    Klein, M.L.3    Amaral, C.4    Treptow, W.5
  • 36
    • 84860199116 scopus 로고    scopus 로고
    • Refinement and Validation of Atomic Models of the Kv1.2 Potassium Channel Through Molecular Dynamics and Gating Charge Calculations
    • Khalili-Araghi, F.; Jogini, V.; Yarov-Yarovoy, V.; Tajkhorshid, E.; Roux, B.; Schulten, K. Refinement and Validation of Atomic Models of the Kv1.2 Potassium Channel Through Molecular Dynamics and Gating Charge Calculations Biophys. J. 2010, 98, 520a-521a
    • (2010) Biophys. J. , vol.98
    • Khalili-Araghi, F.1    Jogini, V.2    Yarov-Yarovoy, V.3    Tajkhorshid, E.4    Roux, B.5    Schulten, K.6
  • 37
    • 68949118408 scopus 로고    scopus 로고
    • Coupling of S4 Helix Translocation and S6 Gating Analyzed by Molecular-Dynamics Simulations of Mutated Kv Channels
    • Nishizawa, M.; Nishizawa, K. Coupling of S4 Helix Translocation and S6 Gating Analyzed by Molecular-Dynamics Simulations of Mutated Kv Channels Biophys. J. 2009, 97, 90-100
    • (2009) Biophys. J. , vol.97 , pp. 90-100
    • Nishizawa, M.1    Nishizawa, K.2
  • 38
    • 83355177269 scopus 로고    scopus 로고
    • In Search of a Consensus Model of the Resting State of a Voltage-Sensing Domain
    • Vargas, E.; Bezanilla, F.; Roux, B. In Search of a Consensus Model of the Resting State of a Voltage-Sensing Domain Neuron 2011, 72, 713-720
    • (2011) Neuron , vol.72 , pp. 713-720
    • Vargas, E.1    Bezanilla, F.2    Roux, B.3
  • 40
    • 79961124704 scopus 로고    scopus 로고
    • R1 in the Shaker S4 Occupies the Gating Charge Transfer Center in the Resting State
    • Lin, M. A.; Hsieh, J.-Y.; Mock, A. F.; Papazian, D. M. R1 in the Shaker S4 Occupies the Gating Charge Transfer Center in the Resting State J. Gen. Physiol. 2011, 138, 155-163
    • (2011) J. Gen. Physiol. , vol.138 , pp. 155-163
    • Lin, M.A.1    Hsieh, J.-Y.2    Mock, A.F.3    Papazian, D.M.4
  • 41
    • 0030175348 scopus 로고    scopus 로고
    • + channel
    • DOI 10.1016/S0896-6273(00)80143-9
    • Aggarwal, S. K.; MacKinnon, R. Contribution of the S4 Segment to Gating Charge in the Shaker K Channel Neuron 1996, 16, 1169-1177 (Pubitemid 26227238)
    • (1996) Neuron , vol.16 , Issue.6 , pp. 1169-1177
    • Aggarwal, S.K.1    MacKinnon, R.2
  • 43
    • 0042171841 scopus 로고    scopus 로고
    • Exploring the origin of the ion selectivity of the KcsA potassium channel
    • DOI 10.1002/prot.10455
    • Burykin, A.; Kato, M.; Warshel, A. Exploring the Origin of the Ion Selectivity of the KcsA Potassium Channel Proteins 2003, 53, 412-426 (Pubitemid 36944857)
    • (2003) Proteins: Structure, Function and Genetics , vol.52 , Issue.3 , pp. 412-426
    • Burykin, A.1    Kato, M.2    Warshel, A.3
  • 44
    • 84856737491 scopus 로고    scopus 로고
    • Sodium Ion Binding Sites and Hydration in the Lumen of a Bacterial Ion Channel from Molecular Dynamics Simulations
    • Carnevale, V.; Treptow, W.; Klein, M. L. Sodium Ion Binding Sites and Hydration in the Lumen of a Bacterial Ion Channel from Molecular Dynamics Simulations J. Phys. Chem. Lett. 2011, 2, 2504-2508
    • (2011) J. Phys. Chem. Lett. , vol.2 , pp. 2504-2508
    • Carnevale, V.1    Treptow, W.2    Klein, M.L.3
  • 45
    • 84863393269 scopus 로고    scopus 로고
    • Mechanism of Ion Permeation and Selectivity in a Voltage Gated Sodium Channel
    • Corry, B.; Thomas, M. Mechanism of Ion Permeation and Selectivity in a Voltage Gated Sodium Channel J. Am. Chem. Soc. 2012, 134, 1840-1846
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 1840-1846
    • Corry, B.1    Thomas, M.2
  • 46
    • 84861119854 scopus 로고    scopus 로고
    • On Conduction in a Bacterial Sodium Channel
    • in press
    • Furini, S.; Domene, C. On Conduction in a Bacterial Sodium Channel. PLOS 2012, in press.
    • (2012) PLOS
    • Furini, S.1    Domene, C.2
  • 47
    • 0017697163 scopus 로고
    • Inactivation of the sodium channel. I. Sodium current experiments
    • Bezanilla, F.; Armstrong, C. M. Inactivation of the Sodium Channel. I. Sodium Current Experiments J. Gen. Physiol. 1977, 70, 549-566 (Pubitemid 8239321)
    • (1977) Journal of General Physiology , vol.70 , Issue.5 , pp. 549-566
    • Bezanilla, F.1    Armstrong, C.M.2
  • 48
    • 7244251461 scopus 로고    scopus 로고
    • Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands
    • DOI 10.1038/nature02943
    • Noskov, S. Y.; Bernèche, S.; Roux, B. Control of Ion Selectivity in Potassium Channels by Electrostatic and Dynamic Properties of Carbonyl Ligands Nature 2004, 431, 830-834 (Pubitemid 39434076)
    • (2004) Nature , vol.431 , Issue.7010 , pp. 830-834
    • Noskov, S.Y.1    Berneche, S.2    Roux, B.3
  • 51
    • 77953029106 scopus 로고    scopus 로고
    • Molecular Simulations of Ion Channels: A Quantum Chemist's Perspective
    • Bucher, D.; Rothlisberger, U. Molecular Simulations of Ion Channels: A Quantum Chemist's Perspective J. Gen. Physiol. 2010, 135, 549-554
    • (2010) J. Gen. Physiol. , vol.135 , pp. 549-554
    • Bucher, D.1    Rothlisberger, U.2
  • 52
    • 73949107784 scopus 로고    scopus 로고
    • Scaling of Multimillion-Atom Biological Molecular Dynamics Simulation on a Petascale Supercomputer
    • Schulz, R.; Lindner, B.; Petridis, L.; Smith, J. C. Scaling of Multimillion-Atom Biological Molecular Dynamics Simulation on a Petascale Supercomputer J. Chem. Theory Comput. 2009, 5, 2798-2808
    • (2009) J. Chem. Theory Comput. , vol.5 , pp. 2798-2808
    • Schulz, R.1    Lindner, B.2    Petridis, L.3    Smith, J.C.4
  • 53
    • 44849103041 scopus 로고    scopus 로고
    • Ab Initio Molecular Dynamics Using Hybrid Density Functionals
    • Guidon, M.; Schiffmann, F.; Hutter, J.; VandeVondele, J. Ab Initio Molecular Dynamics Using Hybrid Density Functionals J. Chem. Phys. 2008, 128, 214104
    • (2008) J. Chem. Phys. , vol.128 , pp. 214104
    • Guidon, M.1    Schiffmann, F.2    Hutter, J.3    Vandevondele, J.4
  • 54
    • 0036899251 scopus 로고    scopus 로고
    • The cation selectivity filter of the bacterial sodium channel, NaChBac
    • DOI 10.1085/jgp.20028699
    • Yue, L.; Navarro, B.; Ren, D.; Ramos, A.; Clapham, D. E. The Cation Selectivity Filter of the Bacterial Sodium Channel, NaChBac J.Gen. Physiol. 2002, 120, 845-853 (Pubitemid 35435016)
    • (2002) Journal of General Physiology , vol.120 , Issue.6 , pp. 845-853
    • Yue, L.1    Navarro, B.2    Ren, D.3    Ramos, A.4    Clapham, D.E.5
  • 55
    • 0026517122 scopus 로고
    • Calcium Channel Characteristics Conferred on the Sodium Channel by Single Mutations
    • Heinemann, S. H.; Terlau, H.; Stuhmer, W.; Imoto, K.; Numa, S. Calcium Channel Characteristics Conferred on the Sodium Channel by Single Mutations Nature 1992, 356, 441-443
    • (1992) Nature , vol.356 , pp. 441-443
    • Heinemann, S.H.1    Terlau, H.2    Stuhmer, W.3    Imoto, K.4    Numa, S.5
  • 56
    • 0027526198 scopus 로고
    • Structural determinants of ion selectivity in brain calcium channel
    • DOI 10.1016/0014-5793(93)80009-J
    • Kim, M. K.; Morii, T.; Sun, L. X.; Imoto, K.; Mori, Y. Structural Determinants of Ion Selectivity in Brain Calcium Channel FEBS Lett. 1993, 318, 145-148 (Pubitemid 23065941)
    • (1993) FEBS Letters , vol.318 , Issue.2 , pp. 145-148
    • Kim, M.-S.1    Morii, T.2    Sun, L.-X.3    Imoto, K.4    Mori, Y.5
  • 57
    • 0035957732 scopus 로고    scopus 로고
    • Mechanisms of tetraethylammonium ion block in the KcsA potassium channel
    • DOI 10.1016/S0014-5793(01)02381-X, PII S001457930102381X
    • Luzhkov, V. B.; Åqvist, J. Mechanisms of Tetraethylammonium Ion Block in the KcsA Potassium Channel FEBS Lett. 2001, 495, 191-196 (Pubitemid 32397703)
    • (2001) FEBS Letters , vol.495 , Issue.3 , pp. 191-196
    • Luzhkov, V.B.1    Aqvist, J.2
  • 58
    • 80053382371 scopus 로고    scopus 로고
    • Molecular Mapping of General Anesthetic Sites in a Voltage-Gated Ion Channel
    • Barber, A. F.; Liang, Q.; Amaral, C.; Treptow, W.; Covarrubias, M. Molecular Mapping of General Anesthetic Sites in a Voltage-Gated Ion Channel Biophys. J. 2011, 101, 1613-1622
    • (2011) Biophys. J. , vol.101 , pp. 1613-1622
    • Barber, A.F.1    Liang, Q.2    Amaral, C.3    Treptow, W.4    Covarrubias, M.5
  • 59
    • 0036840108 scopus 로고    scopus 로고
    • + channel: A computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles
    • + Channel: A Computational Approach Based on Experimental Distance Restraints Extracted from Thermodynamic Mutant Cycles Biophys. J. 2002, 83, 2595-2609 (Pubitemid 35265753)
    • (2002) Biophysical Journal , vol.83 , Issue.5 , pp. 2595-2609
    • Eriksson, M.A.L.1    Roux, B.2
  • 62
    • 33846513431 scopus 로고    scopus 로고
    • Voltage-gated ion channels and gating modifier toxins
    • DOI 10.1016/j.toxicon.2006.09.022, PII S0041010106003461
    • Catterall, W. A.; Cestèle, S.; Yarov-Yarovoy, V.; Yu, F. H.; Konoki, K.; Scheuer, T. Voltage-Gated Ion Channels and Gating Modifier Toxins Toxicon 2007, 49, 124-141 (Pubitemid 46151715)
    • (2007) Toxicon , vol.49 , Issue.2 , pp. 124-141
    • Catterall, W.A.1    Cestele, S.2    Yarov-Yarovoy, V.3    Yu, F.H.4    Konoki, K.5    Scheuer, T.6
  • 63
    • 0141831003 scopus 로고    scopus 로고
    • Structural basis for modulation and agonist specificity of HCN pacemaker channels
    • DOI 10.1038/nature01922
    • Zagotta, W. N.; Olivier, N. B.; Black, K. D.; Young, E. C.; Olson, R.; Gouaux, E. Structural Basis for Modulation and Agonist Specificity of HCN Pacemaker Channels Nature 2003, 425, 200-205 (Pubitemid 37150901)
    • (2003) Nature , vol.425 , Issue.6954 , pp. 200-205
    • Zagotta, W.N.1    Olivier, N.B.2    Black, K.D.3    Young, E.C.4    Olson, R.5    Gouaux, E.6
  • 64
    • 77953304594 scopus 로고    scopus 로고
    • The Membrane-Bound State of K2P Potassium Channels
    • Treptow, W.; Klein, M. L. The Membrane-Bound State of K2P Potassium Channels J. Am. Chem. Soc. 2010, 132, 8145-8151
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 8145-8151
    • Treptow, W.1    Klein, M.L.2
  • 65
    • 78349287755 scopus 로고    scopus 로고
    • Effect of Sensor Domain Mutations on the Properties of Voltage-Gated Ion Channels: Molecular Dynamics Studies of the Potassium Channel Kv1.2
    • Delemotte, L.; Treptow, W.; Klein, M. L.; Tarek, M. Effect of Sensor Domain Mutations on the Properties of Voltage-Gated Ion Channels: Molecular Dynamics Studies of the Potassium Channel Kv1.2 Biophys. J. 2010, 99, L72-74
    • (2010) Biophys. J. , vol.99 , pp. 72-74
    • Delemotte, L.1    Treptow, W.2    Klein, M.L.3    Tarek, M.4
  • 66
    • 84855997898 scopus 로고    scopus 로고
    • Molecular Dynamics Investigation of the ω-Current in the Kv1.2 Voltage Sensor Domains
    • Khalili-Araghi, F.; Tajkhorshid, E.; Roux, B.; Schulten, K. Molecular Dynamics Investigation of the ω-Current in the Kv1.2 Voltage Sensor Domains Biophys. J. 2012, 102, 258-267
    • (2012) Biophys. J. , vol.102 , pp. 258-267
    • Khalili-Araghi, F.1    Tajkhorshid, E.2    Roux, B.3    Schulten, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.