Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Nucleic Acids Research

Volumn 40, Issue 7, 2012, Pages 3018-3030

  Carette, Xavier ^a,b,c   Blondiaux, Nicolas ^a,b,c   Willery, Eve ^a,b,c   Hoos, Sylviane ^c,d   Lecat Guillet, Nathalie ^a,b,c   Lens, Zoé ^b   Wohlkönig, Alexandre ^e   Wintjens, René ^f   Soror, Sameh H ^e   Frénois, Frédéric ^b,j   Dirié, Bertrand ^b,g,h,k   Villeret, Vincent ^b   England, Patrick ^c,d   Lippens, Guy ⁱ   Deprez, Benoit ^b,g,h   Locht, Camille ^a,b,c   Willand, Nicolas ^b,g,h   Baulard, Alain R ^a,b,c  

^a INSERM U1019   (France)

^b UNIV LILLE   (France)

^c CNRS   (France)

^d INSTITUT PASTEUR   (France)

^e VIB   (France)

^f UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^g INSERM   (France)

^h INSTITUT PASTEUR DE LILLE   (France)

ⁱ UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

^j JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^k UNIVERSITY OF ANTWERP   (Belgium)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ETHIONAMIDE; GLYCINE; LIGAND; PROTEIN ETHR; PROTEIN VARIANT; REPRESSOR PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIBIOTIC SENSITIVITY; ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; LIGAND BINDING; MOLECULAR DYNAMICS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION;

AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN FOLDING; REPRESSOR PROTEINS;

EID: 84860179160     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkr1113     Document Type: Article

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