Exploring drug target flexibility using in situ click chemistry: Application to a mycobacterial transcriptional regulator

ACS Chemical Biology

Volumn 5, Issue 11, 2010, Pages 1007-1013

  Willand, Nicolas ^a,b,c,d   Desroses, Matthieu ^a,b,c,d   Toto, Patrick ^a,b,c,d   Dirié, Bertrand ^a,b,c,d   Lens, Zoé ^a,f,g   Villeret, Vincent ^a,f   Rucktooa, Prakash ^a,f   Locht, Camille ^a,c,e   Baulard, Alain ^a,c,d,e   Deprez, Benoit ^a,b,c,d  

^a UNIV LILLE   (France)

^b INSERM   (France)

^c IPL   (France)

^d PRIM   (France)

^e INSERM U1019   (France)

^f CNRS   (France)

^g UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 AZIDO 1 [4 (3 THIOPHEN 2 YL[1,2,4]OXADIAZOL 5 YL)PIPERIDIN 1 YL]ETHANONE; 4 IODO N [1 [2 OXO 2 [4 (3 THIOPHEN 2 YL 1,2,4 OXADIAZOL 5 YL)PIPERIDIN 1 YL]ETHYL] 1H 1,2,3 TRIAZOL 4 YL METHYL]BENZENESULFONAMIDE; ANTIINFECTIVE AGENT; AZIDE; BACTERIAL PROTEIN; BDM 14801; BDM 14950; PEPTIDE FRAGMENT; PHENYLALANINE; PHENYLALANINE DERIVATIVE; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL REPRESSOR ETHR; TRANSCRIPTIONAL REPRESSOR ETHR INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; HYDROPHOBICITY; IN SITU CLICK CHEMISTRY; LIGAND BINDING; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PRECURSOR; PRIORITY JOURNAL; PROTEIN STRUCTURE; SYNTHESIS; TRANSCRIPTION REGULATION;

ANTITUBERCULAR AGENTS; AZIDES; CLICK CHEMISTRY; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; LIGANDS; MYCOBACTERIUM TUBERCULOSIS; OXADIAZOLES; PROTEIN CONFORMATION; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

MYCOBACTERIUM TUBERCULOSIS;

EID: 78649645179     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100177g     Document Type: Article

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