Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis

Tuberculosis

Volumn 86, Issue 2, 2006, Pages 110-114

  Frénois, Frédéric ^a   Baulard, Alain R ^a   Villeret, Vincent ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Drug design; Ethionamide; Helix turn helix; Mycobacterium tuberculosis; TetR family; X ray crystallography

Indexed keywords

BACTERIAL PROTEIN; ETHA PROTEIN; ETHIONAMIDE; ETHR PROTEIN; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; HUMAN; LIGAND BINDING; MOLECULAR RECOGNITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; TRANSCRIPTION INITIATION;

ANTITUBERCULAR AGENTS; DRUG DESIGN; ETHIONAMIDE; HUMANS; LIGANDS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS;

EID: 32444435597     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2005.07.005     Document Type: Article

References (16)

1. L. Fattorini Microb Drug Resist 5 1999 265 270
2. T. Prammananan, W. Arjratanakool, and A. Chaiprasert Int J Tuberc Lung Dis 9 2005 216 219
3. Blanc L, et al. Report WHO/TB/2003.313. Geneva, Switzerland: WHO; 2003.
4. A.R. Baulard, J.C. Betts, and J. Engohang-Ndong J Biol Chem 275 2000 28326 28331
5. Y. Zhang, B. Heym, B. Allen, D. Young, and S. Cole Nature 358 1992 591 593
6. E. Nathanson Int J Tuberc Lung Dis 8 2004 1382 1384
7. T.A. Vannelli, A. Dykman, and P.R. Ortiz De Montellano J Biol Chem 277 2002 12824 12829
8. M.W. Fraaije, N.M. Kamerbeek, A.J. Heidekamp, R. Fortin, and D.B. Janssen J Biol Chem 279 2004 3354 3360
9. J. Engohang-Ndong, D. Baillat, and M. Aumercier Mol Microbiol 51 2004 175 188
10. P. Orth, D. Schnappinger, W. Hillen, W. Saenger, and W. Hinrichs Nat Struct Biol 7 2000 215 219
11. M.A. Schumacher, M.C. Miller, S. Grkovic, M.H. Brown, R.A. Skurray, and R.G. Brennan Science 294 2001 2158 2163
12. M.A. Schumacher, M.C. Miller, S. Grkovic, M.H. Brown, R.A. Skurray, and R.G. Brennan Embo J 21 2002 1210 1218
13. J.L. Huffman, and R.G. Brennan Curr Opin Struct Biol 12 2002 98 106
14. F. Frenois, J. Engohang-Ndong, C. Locht, A.R. Baulard, and V. Villeret Mol Cell 16 2004 301 307
15. L.G. Dover, P.E. Corsino, and I.R. Daniels J Mol Biol 340 2004 1095 1105
16. W. Saenger, P. Orth, C. Kisker, W. Hillen, and W. Hinrichs Angew Chem Int Ed Engl 39 2000 2042 2052