Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: Potential role of NMDA receptor-dependent BDNF signaling

Toxicological Sciences

Volumn 116, Issue 1, 2010, Pages 249-263

  Neal, April P ^a   Stansfield, Kirstie H ^a   Worley, Paul F ^b   Thompson, Richard E ^a   Guilarte, Tomás R ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BDNF; FM 1 43; Lead; Synaptobrevin; Synaptophysin; Vesicular release

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; LEAD; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOPHYSIN; VESICULAR TRANSPORT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EXOCYTOSIS; EXPOSURE; HIPPOCAMPUS; LEAD POISONING; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; SYNAPSE VESICLE; SYNAPTOGENESIS; ANIMAL; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNAPSE; TOXICITY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; LEAD; NEUROGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPSES; VESICULAR TRANSPORT PROTEINS;

EID: 77954360596     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq111     Document Type: Article

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