Prenatal lead exposure, δ-aminolevulinic acid, and schizophrenia

Environmental Health Perspectives

Volumn 112, Issue 5, 2004, Pages 548-552

  Opler, Mark G A ^a,e   Brown, Alan S ^a,b   Graziano, Joseph ^c   Desai, Manisha ^c   Zheng, Wei ^c   Schaefer, Catherine ^d   Factor Litvak, Pamela ^c   Susser, Ezra S ^b,c  

^a Columbia University ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Kaiser Permanente Health Care ^*  (United States)

^d DIVISION OF RESEARCH   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Developmental; Lead; Pb; Prenatal; Prospective; Psychosis; Schizophrenia; aminolevulinic acid

Indexed keywords

AMINOLEVULINIC ACID; BIOLOGICAL MARKER; LEAD;

ADULT; BLOOD SAMPLING; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; COVARIANCE; FEMALE; HUMAN; LEAD BLOOD LEVEL; LOGISTIC REGRESSION ANALYSIS; MALE; MENTAL DISEASE; PRENATAL EXPOSURE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SCHIZOPHRENIA; SECOND TRIMESTER PREGNANCY; UNITED STATES;

EID: 4644273994     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6777     Document Type: Review

References (50)

1. Baghurst PA, McMichael AJ, Vimpani GV, Robertson EF, Clark PD, et al. 1987. Determinants of blood lead concentrations of pregnant women living in Port Pirie and surrounding areas. Med J Aust 146:69-73.
2. Beckmann H. 1999. Developmental malformations in cerebral structures of schizophrenic patients. Eur Arch Psychiatry Clin Neurosci 249(suppl 4):44-47.
3. Bellinger D, Hu H, Titlebaum L, Needleman HL. 1994. Attentional correlates of dentin and bone lead levels in adolescents. Arch Environ Health 49:98-105.
4. Bellinger D, Sloman J, Leviton A, Rabinowitz M, Needleman HL, Waternaux C. 1991. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics 87:219-227.
5. Benes FM. 1997. The role of stress and dopamine-GABA interactions in the vulnerability for schizophrenia. J Psychiatr Res 31:257-275.
6. Bergdahl IA, Grubb A, Schutz A, Desnick RJ, Wetmur JG, Sassa S, et al. 1997. Lead binding to delta-aminolevulinic acid dehydratase (ALAD) in human erythrocytes. Pharmacol Toxicol 81:153-158.
7. Bracha HS, Torrey EF, Gottesman II0, Bigelow LB, Cunniff C. 1992. Second-trimester markers of fetal size in schizophrenia: a study of monozygotic twins. Am J Psychiatry 149:1355-1361.
8. Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan MA. In press. Serologic evidence for prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry.
9. Brown AS, Schaefer CA, Wyatt RJ, Begg MD, Goetz R, Bresnahan MA, et al. 2002. Paternal age and risk of schizophrenia in adult offspring. Am J Psychiatry 159:1528-1533.
10. Brown AS, Schaefer CA, Wyatt RJ, Goetz R, Begg MD, Gorman JM, et al. 2000. Maternal exposure to respiratory infections and adult schizophrenia spectrum disorders: a prospective birth cohort study. Schizophr Bull 26:287-295.
11. Dawson EB, Evans DR, Harris WA, Van Hook JW. 1999. Amniotic fluid B12, calcium, and lead levels associated with neural tube defects. Am J Perinatol 16:373-378.
12. de Klerk M, Weideman A, Malan C, Shanley BC. 1975. Urinary porphyrins and porphyrin precursors in normal pregnancy. Relationship to urinary total oestrogen excretion. S Afr Med J 49:581-583.
13. Dietrich KN, Ris MD, Succop PA, Berger OG, Bornschein RL. 2001. Early exposure to lead and juvenile delinquency. Neurotoxicol Teratol 23:511-518.
14. Endo Y, Okayama A, Endo G, Horiguchi S, Nakazono N. 1993. Improvement of urinary delta-aminolevulinic acid determination by HPLC-fluorometry using pre-column derivatization [in Japanese]. Sangyo Igaku 35:126-127.
15. Estrov Y, Scaglia F, Bodamer OA. 2000. Psychiatric symptoms of inherited metabolic disease. J Inherit Metab Dis 23:2-6.
16. Factor-Litvak P, Wasserman G, Kline JK, Graziano J. 1999. The Yugoslavia Prospective Study of Environmental Lead Exposure. Environ Health Perspect 107:9-15.
17. Graziano JH, Popovac D, Factor-Litvak P, Shrout P, Kline J, Murphy MJ, et al. 1990. Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia. Environ Health Perspect 89:95-100.
18. Greenland S. 2000. When should epidemiologic regressions use random coefficients? Biometrics 56:915-921.
19. Greenland S, Schwartzbaum JA, Finkle WD. 2000. Problems due to small samples and sparse data in conditional logistic regression analysis. Am J Epidemiol 151:531-539.
20. Jones PB, Bebbington P, Foerster A, Lewis SW, Murray RM, Russell A, et al. 1993. Premorbid social underachievement in schizophrenia. Results from the Camberwell Collaborative Psychosis Study. Br J Psychiatry 162:65-71.
21. Kelada SN, Shelton E, Kaufmann RB, Khoury MJ. 2001. Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review. Am J Epidemiol 154:1-13.
22. Kim R, Hu H, Rotnitzky A, Bellinger D, Needleman H. 1995. A longitudinal study of chronic lead exposure and physical growth. Environ Health Perspect 103:952-957.
23. Korpela H, Loueniva R, Yrjanheikki E, Kauppila A. 1986. Lead and cadmium concentrations in maternal and umbilical cord blood, amniotic fluid, placenta, and amniotic membranes. Am J Obstet Gynecol 155:1086-1089.
24. Loghman-Adham M. 1997. Renal effects of environmental and occupational lead exposure. Environ Health Perspect 105:928-939.
25. Ludwig JH, Diggs DR, Hesselberg HE, Maga JA. 1965. Survey of lead in the atmosphere of three urban communities: a summary. Am Ind Hyg Assoc J 26:270-284.
26. Murray RM, Jones P, O'Callaghan E, Takei N, Sham P. 1992. Genes, viruses and neurodevelopmental schizophrenia. J Psychiatr Res 26:225-235.
27. Needleman HL, Gunnoe C, Leviton A, Reed R, Peresie H, Maher C, et al. 1979. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med 300:689-695.
28. Needleman HL, Schell A, Bellinger O, Leviton A, Allred EN. 1990. The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report. N Engl J Med 322:83-88.
29. Neuhaus JM. 1992. Statistical methods for longitudinal and clustered designs with binary responses. Stat Methods Med Res 1:249-273.
30. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. 1994. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51:849-859.
31. Oishi H, Nomiyama H, Nomiyama K, Tomokuni K. 1996. Fluorometric HPLC determination of delta-aminolevulinic acid (ALA). J Anal Toxicol 20:106-110.
32. Olney JW, Newcomer JW, Farber NB. 1999. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 33:523-533.
33. 14C]gamma-aminobutyric acid uptake into neurons and glia in culture. J Neurochem 36:69-76.
34. Pocock SJ, Smith M, Baghurst P. 1994. Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. Br Med J 309:1189-1197.
35. Prozialeck WC, Grunwald GB, Dey PM, Reuhl KR, Parrish AR. 2002. Cadherins and NCAM as potential targets in metal toxicity. Toxicol Appl Pharmacol 182:255-265.
36. Ran S, Scheuer ML, Zheng W. 1998. Determination of lamotrigine in biologic materials by a simple and rapid liquid chromatographic method. Ther Drug Monit 20:209-214.
37. Satcher DS. 2000. The Surgeon General on the continuing tragedy of childhood lead poisoning. Public Health Rep 115:579-580.
38. Sobotka JM, Rahwan R. 1995. Teratogenesis induced by short- and long-term exposure of Xenopus laevis progeny to lead. J Toxicol Environ Health 44:469-484.
39. Susser EB, Brown A, Matte TD. 1999. Prenatal factors and adult mental and physical health. Can J Psychiatry 44:326-334.
40. Susser ES, Schaefer CA, Brown AS, Begg MD, Wyatt RJ. 2000. The design of the Prenatal Determinants of Schizophrenia Study. Schizophr Bull 26:257-273.
41. Thomas HV, Milmore BK, Heidbreder GA, Kogan BA. 1967. Blood lead of persons living near freeways. Arch Environ Health 15:695-702.
42. Tomokuni K, Ichiba M, Fujishiro K. 1993. Interrelation between urinary delta-aminolevulinic acid (ALA), serum ALA, and blood lead in workers exposed to lead. Ind Health 31:51-57.
43. Tong S, McMichael AJ, Baghurst PA. 2000. Interactions between environmental lead exposure and sociodemographic factors on cognitive development. Arch Environ Health 55:330-335.
44. 2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain Res Dev Brain Res 139:217-226.
45. Udry JR, Morris NM, Kovenock J. 1995. Androgen effects on women's gendered behaviour. J Biosoc Sci 27:359-368.
46. Vawter MP. 2000. Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders. Eur J Pharmacol 405:385-395.
47. Vivier PM, Hogan JW, Simon P, Leddy T, Dansereau LM, Alario AJ. 2001. A statewide assessment of lead screening histories of preschool children enrolled in a Medicaid managed care program. Pediatrics 108:E29. Available: http://pediatrics.aappublications.org/cgi/reprint/108/2/e29.pdf [accessed 18 February 2004].
48. Wasserman GA, Liu X, Popovac D, Factor-Litvak P, Kline J, Waternaux C, et al. 2000. The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence. Neurotoxicol Teratol 22:811-818.
49. Weinberger DR. 1996. On the plausibility of "the neurodevelopmental hypothesis" of schizophrenia. Neuropsychopharmacology 14(suppl 3):1S-11S.
50. Zheng W, Blaner WS, Zhao Q. 1999. Inhibition by lead of production and secretion of transthyretin in the choroid plexus: its relation to thyroxine transport at blood-CSF barrier. Toxicol Appl Pharmacol 155:24-31.