Single nucleotide polymorphisms in multiple sclerosis: Disease susceptibility and treatment response biomarkers

Immunologic Research

Volumn 52, Issue 1-2, 2012, Pages 42-52

  Pravica, Vera ^a   Popadic, Dusan ^a   Savic, Emina ^a   Markovic, Milos ^a   Drulovic, Jelena ^a   Mostarica Stojkovic, Marija ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Biomarkers; Ethnic variations; Genetic polymorphism; Interferon beta; Multiple sclerosis; Pharmacogenomics

Indexed keywords

BETA INTERFERON; BIOLOGICAL MARKER; GLYPICAN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

DISEASE PREDISPOSITION; DRUG RESPONSE; ETHNIC DIFFERENCE; GENETIC ASSOCIATION; HUMAN; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; PHARMACOGENOMICS; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM; ENVIRONMENTAL EXPOSURE; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; MULTIPLE SCLEROSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; T-LYMPHOCYTES;

EID: 84859913275     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-012-8273-y     Document Type: Review

References (111)

1. M Pugliatti G Rosati H Carton T Riise J Drulovic L Vecsei I Milanov 2006 The epidemiology of multiple sclerosis in Europe Eur J Neurol 13 700 722 16834700 1:STN:280:DC%2BD28vhsVOguw%3D%3D
2. JH Noseworthy C Lucchinetti M Rodriguez BG Weinshenker 2000 Multiple sclerosis N Engl J Med 343 938 952 11006371 1:STN:280:DC%2BD3cvlvF2quw%3D%3D
3. International Multiple Sclerosis Genetics Consortium 2011 Wellcome Trust Case Control Consortium 2 Nature 476 214 219
4. A Ascherio KL Munger 2007 Environmental risk factors for multiple sclerosis. Part I: the role of infection Ann Neurol 61 288 299 17444504
5. T Pekmezovic J Drulovic M Milenkovic M Jarebinski N Stojsavljevic S Mesaros D Kisic J Kostic 2006 Lifestyle factors and multiple sclerosis: a case-control study in Belgrade Neuroepidemiology 27 212 216 17095875
6. KL Munger LI Levin BW Hollis NS Howard A Ascherio 2006 Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis JAMA 296 2832 2838 17179460 1:CAS:528:DC%2BD28XhtlCqtL3J
7. MT Kampman T Wilsgaard SI Mellgren 2007 Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle J Neurol 254 471 477 17377831 1:STN:280:DC%2BD2s3psFSksA%3D%3D
8. C Lucchinetti W Bruck J Parisi B Scheithauer M Rodriguez H Lassmann 2000 Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination Ann Neurol 47 707 717 10852536 1:STN:280:DC%2BD3czgvFektA%3D%3D
9. FD Lublin SC Reingold 1996 Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis Neurology 46 907 911 8780061 1:STN:280:DyaK28zntlOksg%3D%3D
10. A Compston A Coles 2008 Multiple sclerosis Lancet 372 1502 1517 18970977 1:CAS:528:DC%2BD1cXht12gtLvN
11. J Rio C Nos M Tintore N Tellez I Galan R Pelayo M Comabella X Montalban 2006 Defining the response to interferon-beta in relapsing-remitting multiple sclerosis patients Ann Neurol 59 344 352 16437558 1:CAS:528:DC%2BD28XhvVSks7Y%3D
12. A Miller N Avidan N Tzunz-Henig L Glass-Marmor I Lejbkowicz RY Pinter T Paperna 2008 Translation towards personalized medicine in multiple sclerosis J Neurol Sci 274 68 75 18789804
13. ZM Levic I Dujmovic T Pekmezovic M Jarebinski J Marinkovic N Stojsavljevic J Drulovic 1999 Prognostic factors for survival in multiple sclerosis Mult Scler 5 171 178 10408717 1:STN:280:DyaK1MzjsFajsA%3D%3D
14. Ebers G. Disease evolution in multiple sclerosis. J Neurol. 2006;253:vi3-8.
15. LK Fisniku PA Brex DR Altmann KA Miszkiel CE Benton R Lanyon AJ Thompson DH Miller 2008 Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis Brain 131 808 817 18234696 1:STN:280:DC%2BD1c7jtFaqtw%3D%3D
16. D Miller F Barkhof X Montalban A Thompson M Filippi 2005 Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management Lancet Neurol 4 341 348 15907738 1:CAS:528:DC%2BD2MXls1eis7g%3D
17. J Goverman T Autoimmune 2009 cell responses in the central nervous system Nat Rev Immunol 9 393 407 19444307 1:CAS:528:DC%2BD1MXlvFShs7c%3D
18. JM Fletcher SJ Lalor CM Sweeney N Tubridy KH Mills 2010 T cells in multiple sclerosis and experimental autoimmune encephalomyelitis Clin Exp Immunol 162 1 11 20682002 1:CAS:528:DC%2BC3cXhtlSnsLbK
19. M Montes X Zhang L Berthelot DA Laplaud S Brouard J Jin S Rogan D Armao V Jewells JP Soulillou S Markovic-Plese 2009 Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells Clin Immunol 130 133 144 18977698 1:CAS:528:DC%2BD1MXht1aksg%3D%3D
20. JS Tzartos MA Friese MJ Craner J Palace J Newcombe MM Esiri L Fugger 2008 Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis Am J Pathol 172 146 155 18156204 1:CAS:528:DC%2BD1cXhslOmur0%3D
21. L Durelli L Conti M Clerico D Boselli G Contessa P Ripellino B Ferrero P Eid F Novelli 2009 T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta Ann Neurol 65 499 509 19475668 1:CAS:528: DC%2BD1MXnvFahsL0%3D
22. H Kebir K Kreymborg I Ifergan A Dodelet-Devillers R Cayrol M Bernard F Giuliani N Arbour B Becher A Prat 2007 Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Nat Med 13 1173 1175 17828272 1:CAS:528:DC%2BD2sXhtFagsbzK
23. C Lock G Hermans R Pedotti A Brendolan E Schadt H Garren A Langer-Gould S Strober B Cannella J Allard P Klonowski A Austin N Lad N Kaminski SJ Galli JR Oksenberg CS Raine R Heller L Steinman 2002 Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis Nat Med 8 500 508 11984595 1:CAS:528:DC%2BD38Xjt1Kgur8%3D
24. D Matusevicius P Kivisakk B He N Kostulas V Ozenci S Fredrikson H Link 1999 Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis Mult Scler 5 101 104 10335518 1:CAS:528:DyaK1MXjtFyms70%3D
25. G Frisullo V Nociti R Iorio AK Patanella A Marti M Caggiula M Mirabella PA Tonali AP Batocchi 2008 IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis Cytokine 44 22 25 18793860 1:CAS:528:DC%2BD1cXhtFOmt7%2FM
26. MA Friese L Fugger 2009 Pathogenic CD8(+) T cells in multiple sclerosis Ann Neurol 66 132 141 19743458 1:CAS:528:DC%2BD1MXht1ansrbJ
27. K Venken N Hellings R Liblau P Stinissen 2010 Disturbed regulatory T cell homeostasis in multiple sclerosis Trends Mol Med 16 58 68 20159585 1:CAS:528:DC%2BC3cXitVKgsbk%3D
28. SE Blink SD Miller 2009 The contribution of gammadelta T cells to the pathogenesis of EAE and MS Curr Mol Med 9 15 22 19199938 1:CAS:528: DC%2BD1MXkvVSgsLg%3D
29. SP Berzins MJ Smyth AG Baxter 2011 Presumed guilty: natural killer T cell defects and human disease Nat Rev Immunol 11 131 142 21267014 1:CAS:528:DC%2BC3MXhtVajtbY%3D
30. M Hirotani M Niino H Sasaki 2010 The role of B cells in multiple sclerosis: implications for B-cell-targeted therapy Curr Med Chem 17 3215 3222 20666723 1:CAS:528:DC%2BC3cXhtF2rtbnJ
31. R Egg M Reindl F Deisenhammer C Linington T Berger 2001 Anti-MOG and anti-MBP antibody subclasses in multiple sclerosis Mult Scler 7 285 289 11724443 1:CAS:528:DC%2BD3MXosVSns7o%3D
32. M Markovic V Trajkovic J Drulovic S Mesaros N Stojsavljevic I Dujmovic 2003 Mostarica Stojkovic M. Antibodies against myelin oligodendrocyte glycoprotein in the cerebrospinal fluid of multiple sclerosis patients J Neurol Sci 211 67 73 12767500 1:CAS:528:DC%2BD3sXktFWmu70%3D
33. F Di Pauli S Mader K Rostasy K Schanda B Bajer-Kornek R Ehling F Deisenhammer M Reindl T Berger 2011 Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases Clin Immunol 138 247 254 21169067
34. J Kuhle C Pohl M Mehling G Edan MS Freedman HP Hartung CH Polman DH Miller X Montalban F Barkhof L Bauer S Dahms R Lindberg L Kappos R Sandbrink 2007 Lack of association between antimyelin antibodies and progression to multiple sclerosis N Engl J Med 356 371 378 17251533 1:CAS:528: DC%2BD2sXhtVGrsb0%3D
35. A Ray MK Mann S Basu BN Dittel 2011 A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis J Neuroimmunol 230 1 9 21145597 1:CAS:528:DC%2BC3MXntVajsA%3D%3D
36. R Gandhi A Laroni HL Weiner 2010 Role of the innate immune system in the pathogenesis of multiple sclerosis J Neuroimmunol 221 7 14 19931190 1:CAS:528:DC%2BC3cXks1Sjsr4%3D
37. Ž Težak MV Kondratovich E Mansfield 2010 US FDA and personalized medicine: in vitro diagnostic regulatory perspective Pers Med 7 517 530
38. A Alcina M Fedetz D Ndagire O Fernandez L Leyva M Guerrero MM Abad-Grau C Arnal C Delgado M Lucas G Izquierdo F Matesanz 2009 IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D) PLoS One 4 e4137 19125193
39. F Blanco-Kelly F Matesanz A Alcina M Teruel LM Diaz-Gallo M Gomez-Garcia MA Lopez-Nevot L Rodrigo A Nieto C Cardena G Alcain M Diaz-Rubio EG de la Concha O Fernandez R Arroyo J Martin E Urcelay 2010 CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility PLoS One 5 e11520 20634952
40. M Zoledziewska G Costa M Pitzalis E Cocco C Melis L Moi P Zavattari R Murru R Lampis L Morelli F Poddie P Frongia P Pusceddu M Bajorek A Marras AM Satta A Chessa M Pugliatti S Sotgiu MB Whalen G Rosati F Cucca MG Marrosu 2009 Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia Genes Immun 10 15 17 18946483 1:CAS:528:DC%2BD1MXotVemtg%3D%3D
41. Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 661 678
42. I Le Gall AM Chausse A Marcadet P Millasseau D Beaud'Huy-Lancelin MP Font P Paul B Sayagh M Masse C Massart, et al. 1986 New methods for detection of HLA genes polymorphism useful for associated diseases studies Pathol Biol (Paris) 34 801 807
43. O Olerup J Hillert S Fredrikson T Olsson S Kam-Hansen E Moller B Carlsson J Wallin 1989 Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities Proc Natl Acad Sci USA 86 7113 7117 2571150 1:CAS:528:DyaL1MXmtlSntr4%3D
44. DG Haegert M Michaud C Schwab GS Francis 1990 Multiple sclerosis and HLA class II susceptibility and resistance genes J Neurosci Res 26 66 73 1972763 1:CAS:528:DyaK3cXksFKku78%3D
45. MA Robinson TJ Kindt 1992 Linkage between T cell receptor genes and susceptibility to multiple sclerosis: a complex issue Reg Immunol 4 274 283 1290747 1:STN:280:DyaK3s7ns1Kksg%3D%3D
46. C Vandevyver P Raus P Stinissen L Philippaerts JJ Cassiman J Raus 1994 Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis Eur J Immunogenet 21 377 382 9098447 1:STN:280: DyaK2s3lt12ruw%3D%3D
47. TW Huizinga RG Westendorp EL Bollen V Keijsers BM Brinkman JA Langermans FC Breedveld CL Verweij L van de Gaer L Dams JB Crusius A Garcia-Gonzalez BW van Oosten CH Polman AS Pena 1997 TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients J Neuroimmunol 72 149 153 9042107 1:CAS:528:DyaK2sXhslanug%3D%3D
48. K Vandenbroeck G Martino M Marrosu A Consiglio M Zaffaroni S Vaccargiu D Franciotta M Ruggeri G Comi LM Grimaldi 1997 Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis J Neuroimmunol 76 189 192 9184650
49. A Ligers C Xu S Saarinen J Hillert O Olerup 1999 The CTLA-4 gene is associated with multiple sclerosis J Neuroimmunol 97 182 190 10408973 1:CAS:528:DyaK1MXksVygtrw%3D
50. S Hoffjan D Nicolae C Ober 2003 Association studies for asthma and atopic diseases: a comprehensive review of the literature Respir Res 4 14 14748924
51. LA Hindorff P Sethupathy HA Junkins EM Ramos JP Mehta FS Collins TA Manolio 2009 Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc Natl Acad Sci USA 106 9362 9367 19474294 1:CAS:528:DC%2BD1MXot1Cgur4%3D
52. DA Hafler A Compston S Sawcer ES Lander MJ Daly PL De Jager PI de Bakker SB Gabriel DB Mirel AJ Ivinson MA Pericak-Vance SG Gregory JD Rioux JL McCauley JL Haines LF Barcellos B Cree JR Oksenberg SL Hauser 2007 Risk alleles for multiple sclerosis identified by a genomewide study N Engl J Med 357 851 862 17660530 1:CAS:528:DC%2BD2sXpvVyltrY%3D
53. Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet. 2009;41:824-8.
54. SE Baranzini J Wang RA Gibson N Galwey Y Naegelin F Barkhof EW Radue RL Lindberg BM Uitdehaag MR Johnson A Angelakopoulou L Hall JC Richardson RK Prinjha A Gass JJ Geurts J Kragt M Sombekke H Vrenken P Qualley RR Lincoln R Gomez SJ Caillier MF George H Mousavi R Guerrero DT Okuda BA Cree AJ Green E Waubant DS Goodin D Pelletier PM Matthews SL Hauser L Kappos CH Polman JR Oksenberg 2009 Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis Hum Mol Genet 18 767 778 19010793 1:CAS:528:DC%2BD1MXhtVWjsb0%3D
55. BA Johnson J Wang EM Taylor SJ Caillier J Herbert OA Khan AH Cross PL De Jager PA Gourraud BC Cree SL Hauser JR Oksenberg 2010 Multiple sclerosis susceptibility alleles in African Americans Genes Immun 11 343 350 19865102 1:STN:280:DC%2BC3cznsFGqsw%3D%3D
56. PL De Jager X Jia J Wang PI de Bakker L Ottoboni NT Aggarwal L Piccio S Raychaudhuri D Tran C Aubin R Briskin S Romano SE Baranzini JL McCauley MA Pericak-Vance JL Haines RA Gibson Y Naeglin B Uitdehaag PM Matthews L Kappos C Polman WL McArdle DP Strachan D Evans AH Cross MJ Daly A Compston SJ Sawcer HL Weiner SL Hauser DA Hafler JR Oksenberg 2009 Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci Nat Genet 41 776 782 19525953
57. JP Rubio J Stankovich J Field N Tubridy M Marriott C Chapman M Bahlo D Perera LJ Johnson BD Tait MD Varney TP Speed BV Taylor SJ Foote H Butzkueven TJ Kilpatrick 2008 Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians Genes Immun 9 624 630 18650830 1:CAS:528:DC%2BD1cXht1Krtb3M
58. Pandit L, Ban M, Sawcer S, Singhal B, Nair S, Radhakrishnan K, Shetty R, Misri Z, Hegde S, Bhat IG. Evaluation of the established non-MHC multiple sclerosis loci in an Indian population. Mult Scler (Houndmills, Basingstoke, England) 2011;17:139-43.
59. E Jakkula V Leppa AM Sulonen T Varilo S Kallio A Kemppinen S Purcell K Koivisto P Tienari ML Sumelahti I Elovaara T Pirttila M Reunanen A Aromaa AB Oturai HB Sondergaard HF Harbo IL Mero SB Gabriel DB Mirel SL Hauser L Kappos C Polman PL De Jager DA Hafler MJ Daly A Palotie J Saarela L Peltonen 2010 Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene Am J Hum Genet 86 285 291 20159113 1:CAS:528:DC%2BC3cXlt1Klsr8%3D
60. International Multiple Sclerosis Genetics Consortium. The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study. PLoS One 2011;6:e18813.
61. Lill CM RJ, McQueen MB, Bagade S, Schjeide BM, Zipp F, Bertram L. The MSGene database. Alzheimer Research Forum.
62. F Weber B Fontaine I Cournu-Rebeix A Kroner M Knop S Lutz F Muller-Sarnowski M Uhr T Bettecken M Kohli S Ripke M Ising P Rieckmann D Brassat G Semana MC Babron S Mrejen C Gout O Lyon-Caen J Yaouanq G Edan M Clanet F Holsboer F Clerget-Darpoux B Muller-Myhsok 2008 IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations Genes Immun 9 259 263 18354419 1:CAS:528:DC%2BD1cXkvFyksr8%3D
63. DA Akkad S Hoffjan E Petrasch-Parwez J Beygo R Gold JT Epplen 2009 Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients J Autoimmun 32 110 115 19231135 1:CAS:528:DC%2BD1MXjsVOnsLg%3D
64. SG Gregory S Schmidt P Seth JR Oksenberg J Hart A Prokop SJ Caillier M Ban A Goris LF Barcellos R Lincoln JL McCauley SJ Sawcer DA Compston B Dubois SL Hauser MA Garcia-Blanco MA Pericak-Vance JL Haines 2007 Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis Nat Genet 39 1083 1091 17660817 1:CAS:528:DC%2BD2sXps12gtb8%3D
65. JP McElroy JR Oksenberg 2011 Multiple sclerosis genetics 2010 Neurol Clin 29 219 231 21439438
66. F Lundmark K Duvefelt E Iacobaeus I Kockum E Wallstrom M Khademi A Oturai LP Ryder J Saarela HF Harbo EG Celius H Salter T Olsson J Hillert 2007 Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis Nat Genet 39 1108 1113 17660816 1:CAS:528: DC%2BD2sXps12gtb0%3D
67. CJ Jensen J Stankovich A Van der Walt M Bahlo BV Taylor IA van der Mei SJ Foote TJ Kilpatrick LJ Johnson E Wilkins J Field P Danoy MA Brown JP Rubio H Butzkueven 2010 Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients PLoS One 5 e10003 20368992
68. AG Wilson JA Symons TL McDowell HO McDevitt GW Duff 1997 Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation Proc Natl Acad Sci USA 94 3195 3199 9096369 1:CAS:528:DyaK2sXisVKgtbg%3D
69. SA Wirz MC Morale B Marchetti AM Barr S Sotgiu G Rosati M Pugliatti MV Sanna O Giliberto T Bartfai B Conti 2004 High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia Cytokine 26 149 154 15149631 1:CAS:528:DC%2BD2cXktVKhu74%3D
70. MA Kauffman DG Moron G Sandoval RE Sica O Garcea AM Villa 2007 Is tumor necrosis factor-376A promoter polymorphism associated with susceptibility to multiple sclerosis? Medicina 67 436 438 18051225 1:CAS:528:DC%2BD1cXit12gsrc%3D
71. E Losonczi K Bencsik ZF Nagy V Honti E Szalczer C Rajda Z Illes K Matyas C Rozsa T Csepany J Fuvesi L Vecsei 2009 Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis J Nneuroimmunol 208 115 118 1:CAS:528:DC%2BD1MXjsV2mtbk%3D
72. A Martinez A Rubio E Urcelay M Fernandez-Arquero V De Las Heras R Arroyo P Villoslada X Montalban EG De La Concha 2004 TNF-376A marks susceptibility to MS in the Spanish population: a replication study Neurology 62 809 810 15007139 1:CAS:528:DC%2BD2cXhtlejurY%3D
73. A Akcali S Pehlivan M Pehlivan T Sever P Akgul M Neyal 2010 TNF-alpha promoter polymorphisms in multiple sclerosis: no association with -308 and -238 alleles, but the -857 alleles in associated with the disease in Turkish patients Int J Immunogenet 37 91 95 20082645 1:CAS:528:DC%2BC3cXjvVOitbs%3D
74. C Perrey SJ Turner V Pravica WM Howell IV Hutchinson 1999 ARMS-PCR methodologies to determine IL-10, TNF-alpha, TNF-beta and TGF-beta 1 gene polymorphisms Transpl Immunol 7 127 128 10544444 1:CAS:528:DyaK1MXnt1Clt70%3D
75. J Drulovic D Popadic S Mesaros I Dujmovic I Cvetkovic D Miljkovic N Stojsavljevic V Pravica T Pekmezovic G Bogdanovic M Jarebinski M Mostarica Stojkovic 2003 Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis Eur Neurol 50 25 29 12824709 1:CAS:528:DC%2BD3sXkvVegsrs%3D
76. M Veugelers J Vermeesch G Reekmans R Steinfeld P Marynen G David 1997 Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family Genomics 40 24 30 9070915 1:CAS:528:DyaK2sXhtlShtLc%3D
77. G Luxardi A Galli S Forlani K Lawson F Maina R Dono 2007 Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain Biochem Biophys Res Commun 352 55 60 17107664 1:CAS:528:DC%2BD28Xht1Oht7jL
78. ML Cavanillas O Fernandez M Comabella A Alcina M Fedetz G Izquierdo M Lucas MC Cenit R Arroyo K Vandenbroeck I Alloza M Garcia-Barcina A Antiguedad L Leyva CL Gomez J Olascoaga D Otaegui Y Blanco A Saiz X Montalban F Matesanz E Urcelay 2011 Replication of top markers of a genome-wide association study in multiple sclerosis in Spain Genes Immun 12 110 115 20944657 1:CAS:528: DC%2BC3MXislejtb8%3D
79. Y Li CC Sheu Y Ye M de Andrade L Wang SC Chang MC Aubry JA Aakre MS Allen F Chen JM Cunningham C Deschamps R Jiang J Lin RS Marks VS Pankratz L Su Z Sun H Tang G Vasmatzis CC Harris MR Spitz J Jen R Wang ZF Zhang DC Christiani X Wu P Yang 2010 Genetic variants and risk of lung cancer in never smokers: a genome-wide association study Lancet Oncol 11 321 330 20304703 1:CAS:528:DC%2BC3cXjvF2nurs%3D
80. AL Peters RM Plenge RR Graham DM Altshuler KL Moser PM Gaffney GA Bishop 2008 A novel polymorphism of the human CD40 receptor with enhanced function Blood 112 1863 1871 18591382 1:CAS:528:DC%2BD1cXhtVylu7vL
81. D Buck A Kroner P Rieckmann M Maurer H Wiendl 2006 Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis Tissue Antigens 68 335 338 17026470 1:CAS:528:DC%2BD28XhtlantL3M
82. M Duddy A Haghikia E Cocco C Eggers J Drulovic O Carmona H Zephir R Gold 2011 Managing MS in a changing treatment landscape J Neurol 258 728 739 21437661
83. S Dhib-Jalbut S Marks 2010 Interferon-beta mechanisms of action in multiple sclerosis Neurology 74 Suppl 1 S17 S24 20038758 1:CAS:528: DC%2BD1MXhs1ait7fP
84. CH Polman A Bertolotto F Deisenhammer G Giovannoni HP Hartung B Hemmer J Killestein HF McFarland J Oger AR Pachner J Petkau AT Reder SC Reingold H Schellekens PS Sorensen 2010 Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis Lancet Neurol 9 740 750 20610349 1:CAS:528:DC%2BC3cXpsFajur0%3D
85. R Alvarez-Lafuente F Blanco-Kelly M Garcia-Montojo A Martinez V De Las Heras MI Dominguez-Mozo M Bartolome A Garcia-Martinez EG De la Concha E Urcelay R Arroyo 2011 CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment Mult Scler 17 513 520 21177319 1:CAS:528:DC%2BC3MXoslOrtr4%3D
86. J Drulovic E Savic T Pekmezovic S Mesaros N Stojsavljevic I Dujmovic-Basuroski J Kostic V Vasic M Mostarica Stojkovic D Popadic 2009 Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment? J Neuroimmunol 215 90 95 19695714 1:CAS:528:DC%2BD1MXht1Gmt73J
87. E Byun SJ Caillier X Montalban P Villoslada O Fernandez D Brassat M Comabella J Wang LF Barcellos SE Baranzini JR Oksenberg 2008 Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis Arch Neurol 65 337 344 18195134
88. Cenit MD, Blanco-Kelly F, de las Heras V, Bartolome M, de la Concha EG, Urcelay E, Arroyo R, Martinez A. Glypican 5 is an interferon-beta response gene: a replication study. Mult Scle (Houndmills, Basingstoke, England) 2009;15:913-7.
89. MA Chernousov K Rothblum RC Stahl A Evans L Prentiss DJ Carey 2006 Glypican-1 and alpha4(V) collagen are required for Schwann cell myelination J Neurosci 26 508 517 16407548 1:CAS:528:DC%2BD28XosFWrsQ%3D%3D
90. JS Lee CB Chien 2004 When sugars guide axons: insights from heparan sulphate proteoglycan mutants Nat Rev Genet 5 923 935 15573124 1:CAS:528:DC%2BD2cXhtVarsLbO
91. D Van Vactor DP Wall KG Johnson 2006 Heparan sulfate proteoglycans and the emergence of neuronal connectivity Curr Opin Neurobiol 16 40 51 16417999
92. W Worapamorn HR Haase H Li PM Bartold 2001 Growth factors and cytokines modulate gene expression of cell-surface proteoglycans in human periodontal ligament cells J Cell Physiol 186 448 456 11169984 1:CAS:528: DC%2BD3MXhtVGisLo%3D
93. L Leyva O Fernandez M Fedetz E Blanco VE Fernandez B Oliver A Leon MJ Pinto-Medel C Mayorga M Guerrero G Luque A Alcina F Matesanz 2005 IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response J Neuroimmunol 163 165 171 15885318 1:CAS:528:DC%2BD2MXktVGlur8%3D
94. C O'Doherty A Favorov S Heggarty C Graham O Favorova M Ochs S Hawkins M Hutchinson K O'Rourke K Vandenbroeck 2009 Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients Pharmacogenomics 10 1177 1186 19604093
95. S Hoffmann S Cepok V Grummel K Lehmann-Horn J Hackermuller PF Stadler HP Hartung A Berthele F Deisenhammer R Wassmuth B Hemmer 2008 HLA-DRB1*s0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis Am J Hum Genet 83 219 227 18656179 1:CAS:528:DC%2BD1cXpvVOhs7s%3D
96. Weber F, Cepok S, Wolf C, Berthele A, Uhr M, Bettecken T, Buck D, Hartung HP, Holsboer F, Muller-Myhsok B, Hemmer B. Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-beta therapy in multiple sclerosis patients. Pharmacogenomics J. 2011. doi: 10.1038/tpj.2011.14.
97. A Martinez V de las Heras A Mas Fontao M Bartolome EG de la Concha E Urcelay R Arroyo 2006 An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients J Neuroimmunol 173 196 199 16430971 1:CAS:528:DC%2BD28Xis1Srsrc%3D
98. V Pravica C Perrey A Stevens JH Lee IV Hutchinson 2000 A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production Hum Immunol 61 863 866 11053629 1:CAS:528: DC%2BD3cXosVWlu7s%3D
99. C Enevold AB Oturai PS Sorensen LP Ryder N Koch-Henriksen K Bendtzen 2010 Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients Mult Scler 16 942 949 20595247 1:CAS:528:DC%2BC3cXhtFOrt7fK
100. D Mirowska-Guzel G Gromadzka A Mach A Czlonkowski A Czlonkowska 2011 Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-alpha polymorphisms with risk and clinical course of multiple sclerosis in a Polish population J Neuroimmunol 236 87 92 21621860 1:CAS:528:DC%2BC3MXptVyms7k%3D
101. S Sarial MA Shokrgozar A Amirzargar F Shokri J Radfar P Zohrevand Z Arjang MA Sahraian J Lotfi 2008 IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis Iran J Allergy Asthma Immunol 7 37 40 18322311 1:CAS:528:DC%2BD1cXpt1OqtbY%3D
102. S Ristic L Lovrecic N Starcevic-Cizmarevic B Brajenovic-Milic S Sega Jazbec J Sepcic M Kapovic B Peterlin 2007 Tumor necrosis factor-alpha-308 gene polymorphism in Croatian and Slovenian multiple sclerosis patients Eur Neurol 57 203 207 17268200 1:CAS:528:DC%2BD2sXkvFKit7c%3D
103. S Mihailova M Ivanova A Mihaylova L Quin O Mikova E Naumova 2005 Pro- and anti-inflammatory cytokine gene polymorphism profiles in Bulgarian multiple sclerosis patients J Neuroimmunol 168 138 143 16183136 1:CAS:528: DC%2BD2MXhtVynt7nN
104. AE Handel L Handunnetthi AJ Berlanga CT Watson JM Morahan SV Ramagopalan 2010 The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression PLoS One 5 e10142 20405052
105. CA Dendrou V Plagnol E Fung JH Yang K Downes JD Cooper S Nutland G Coleman M Himsworth M Hardy O Burren B Healy NM Walker K Koch WH Ouwehand JR Bradley NJ Wareham JA Todd LS Wicker 2009 Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource Nat Genet 41 1011 1015 19701192 1:CAS:528:DC%2BD1MXhtVaksrnI
106. LM Maier CE Lowe J Cooper K Downes DE Anderson C Severson PM Clark B Healy N Walker C Aubin JR Oksenberg SL Hauser A Compston S Sawcer PL De Jager LS Wicker JA Todd DA Hafler 2009 IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production PLoS Genet 5 e1000322 19119414
107. MH Sombekke LF van der Voort JJ Kragt JM Nielsen H Guzel A Visser CB Oudejans JB Crusius AS Pena H Vrenken CH Polman J Killestein 2011 Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis Mult Scler 17 922 930 21543551 1:CAS:528:DC%2BC3MXhtFKjt7rN
108. A Alcina K Vandenbroeck D Otaegui A Saiz JR Gonzalez O Fernandez ML Cavanillas MC Cenit R Arroyo I Alloza M Garcia-Barcina A Antiguedad L Leyva G Izquierdo M Lucas M Fedetz MJ Pinto-Medel J Olascoaga Y Blanco M Comabella X Montalban E Urcelay F Matesanz 2010 The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis Genes Immun 11 439 445 20508602 1:CAS:528:DC%2BC3cXptVCksL0%3D
109. M Comabella DW Craig C Morcillo-Suarez J Rio A Navarro M Fernandez R Martin X Montalban 2009 Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis Arch Neurol 66 972 978 19667218
110. S Cunningham C Graham M Hutchinson A Droogan K O'Rourke C Patterson G McDonnell S Hawkins K Vandenbroeck 2005 Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes Clin Pharmacol Ther 78 635 646 16338279 1:CAS:528:DC%2BD2MXhtlShsLnL
111. M O'Brien R Lonergan L Costelloe K O'Rourke JM Fletcher K Kinsella C Sweeney G Antonelli KH Mills C O'Farrelly M Hutchinson N Tubridy 2010 OAS1: a multiple sclerosis susceptibility gene that influences disease severity Neurology 75 411 418 20679634