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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3256-3260

Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies

(7) Alvala, Mallika a Bhatnagar, Shubhmita a Ravi, Alvala b Jeankumar, Variam Ullas a Manjashetty, Thimmappa H a Yogeeswari, Perumal a Sriram, Dharmarajan a

a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE (India)

b G Pulla Reddy College of Pharmacy (India)

Author keywords

Acridinedione derivatives; Antiproliferative activity; hSIRT1; MDA MB231

Indexed keywords

ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; N (9 (2 4 6 (BENZYLOXY)PHENYL) 3,3,6,6 TETRAMETHYL 1,8 DIOXO 1,2,3,4,5,6,7,8 OCTAHYDROACRIDIN 10(9H) YL)ISONICOTINAMIDE; SIRTUIN 1; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACETYLATION; ACRIDINES; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GROWTH INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SIRTUIN 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859863996 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.030 Document Type: Article

Times cited : (37)

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