The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP beta

Molecular Cancer Research

Volumn 10, Issue 4, 2012, Pages 558-569

  Ritter, Heather D ^a,b   Antonova, Lilia ^a,b   Mueller, Christopher R ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; GA BINDING PROTEIN; GA BINDING PROTEIN BETA; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; STRESS HORMONE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; BREAST CANCER; CANCER RISK; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STRESS; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENES, BRCA1; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION;

MAMMALIA;

EID: 84859850987     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0423-T     Document Type: Article

References (54)

1. Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994;266:120-2. (Pubitemid 24345332)
2. Thompson ME, Jensen RA, Obermiller PS, Page DL, Holt JT. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet 1995;9:444-50.
3. Lee WY, Jin YT, Chang TW, Lin PW, Su IJ. Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters. Histopathology 1999;34:106-12.
4. Seery LT, Knowlden JM, Gee JM, Robertson JF, Kenny FS, Ellis IO, et al. BRCA1 expression levels predict distant metastasis of sporadic breast cancers. Int J Cancer 1999;84:258-62. (Pubitemid 29256751)
5. Wilson CA, Ramos L, Villasenor MR, Anders KH, Press MF, Clarke K, et al. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 1999; 21:236-40. (Pubitemid 29070375)
6. Taylor J, Lymboura M, Pace PE, A'HernRP, Desai AJ, Shousha S, et al. An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int J Cancer 1998;79:334-42. (Pubitemid 28359729)
7. Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, et al. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila) 2010;3:48-61.
8. Boulton SJ. Cellular functions of the BRCA tumour-suppressor proteins. Biochem Soc Trans 2006;34:633-45. (Pubitemid 44796392)
9. Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, et al. BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A 2008;105:1680-5. (Pubitemid 351346574)
10. Mueller CR, Roskelley CD. Regulation of BRCA1 expression and its relationship to sporadic breast cancer. Breast Cancer Res 2003;5: 45-52. (Pubitemid 36553579)
11. Atlas E, Stramwasser M, Whiskin K, Mueller CR. GA-binding protein alpha/beta is a critical regulator of the BRCA1 promoter. Oncogene 2000;19:1933-40. (Pubitemid 30219036)
12. LaMarco K, Thompson CC, Byers BP, Walton EM, McKnight SL. Identification of Ets- and notch-related subunits in GA binding protein. Science 1991;253:789-92. (Pubitemid 21917218)
13. Rosmarin AG, Resendes KK, Yang Z, McMillan JN, Fleming SL. GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions. Blood Cells Mol Dis 2004;32:143-54. (Pubitemid 38147712)
14. Fromm L, Burden SJ. Synapse-specific and neuregulin-induced transcription require an ets site that binds GABPalpha/GABPbeta. Genes Dev 1998;12:3074-83. (Pubitemid 28469308)
15. Thompson C, Macdonald G, Mueller CR. Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex. Mol Cancer 2011; 10:62.
16. Antonova L, Aronson K, Mueller CR. Stress and breast cancer: from epidemiology to molecular biology. Breast Cancer Res 2011;13:208.
17. Keinan-Boker L, Vin-Raviv N, Liphshitz I, Linn S, Barchana M. Cancer incidence in Israeli Jewish survivors of World War II. J Natl Cancer Inst 2009;101:1489-500.
18. Koupil I, Plavinskaja S, Parfenova N, Shestov DB, Danziger PD, Vagero D. Cancer mortality in women and men who survived the siege of Leningrad (1941-1944). Int J Cancer 2009;124:1416-21.
19. Antonova L, Mueller CR. Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer. Genes Chromosomes Cancer 2008;47:341-52. (Pubitemid 351323764)
20. Encio IJ, Detera-Wadleigh SD. The genomic structure of the human glucocorticoid receptor. J Biol Chem 1991;266:7182-8. (Pubitemid 21906349)
21. Maggi A. Liganded and unliganded activation of estrogen receptor and hormone replacement therapies. Biochim Biophys Acta 2011;1812: 1054-60.
22. Tanaka H, Makino Y, Miura T, Hirano F, Okamoto K, Komura K, et al. Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway. J Immunol 1996;156:1601-8. (Pubitemid 26065873)
23. Eickelberg O, Roth M, Lorx R, Bruce V, Rudiger J, Johnson M, et al. Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 1999;274: 1005-10.
24. Kotitschke A, Sadie-Van Gijsen H, Avenant C, Fernandes S, Hapgood JP. Genomic and nongenomic cross talk between the gonadotropin-releasing hormone receptor and glucocorticoid receptor signaling pathways. Mol Endocrinol 2009;23:1726-45.
25. Verhoog NJ, Du Toit A, Avenant C, Hapgood JP. Glucocorticoidindependent repression of tumor necrosis factor (TNF) alpha-stimulated interleukin (IL)-6 expression by the glucocorticoid receptor: a potential mechanism for protection against an excessive inflammatory response. J Biol Chem 2011;286:19297-310.
26. Conde I, Paniagua R, Fraile B, Lucio J, Arenas MI. Glucocorticoid receptor changes its cellular location with breast cancer development. Histol Histopathol 2008;23:77-85.
27. MacDonald G, Stramwasser M, Mueller CR. Characterization of a negative transcriptional element in the BRCA1 promoter. Breast Cancer Res 2007;9:R49.
28. Pearce D, Yamamoto KR. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 1993;259:1161-5. (Pubitemid 23085354)
29. Schena M, Freedman LP, Yamamoto KR. Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes Dev 1989;3:1590-601.
30. Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:e45.
31. Mahajan DK, London SN. Mifepristone (RU486): a review. Fertil Steril 1997;68:967-76. (Pubitemid 28013354)
32. Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, et al. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature 2011;477:179-84.
33. Lien HC, Lu YS, Cheng AL, Chang WC, Jeng YM, Kuo YH, et al. Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms. J Pathol 2006;209:317-27.
34. Buxant F, Engohan-Aloghe C, Noel JC. Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancer. Appl Immunohistochem Mol Morphol 2010;18:254-7.
35. Smith RA, Lea RA, Curran JE, Weinstein SR, Griffiths LR. Expression of glucocorticoid and progesterone nuclear receptor genes in archival breast cancer tissue. Breast Cancer Res 2003;5:R9-12.
36. Belova L, Delgado B, Kocherginsky M, Melhem A, Olopade OI, Conzen SD. Glucocorticoid receptor expression in breast cancer associates with older patient age. Breast Cancer Res Treat 2009; 116:441-7.
37. Turner JD, Alt SR, Cao L, Vernocchi S, Trifonova S, Battello N, et al. Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more. Biochem Pharmacol 2010;80:1860-8.
38. Szyf M. The early life environment and the epigenome. Biochim Biophys Acta 2009;1790:878-85.
39. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12:342-8.
40. Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008;3:97-106.
41. Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, et al. Progesterone induces adult mammary stem cell expansion. Nature 2010;465:803-7.
42. Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, et al. Control of mammary stem cell function by steroid hormone signalling. Nature 2010;465:798-802.
43. Vogel JL, Kristie TM. The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. EMBO J 2000;19:683-90. (Pubitemid 30093741)
44. Sawa C, Yoshikawa T, Matsuda-Suzuki F, Delehouzee S, Goto M, Watanabe H, et al. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. J Biol Chem 2002;277:22484-90. (Pubitemid 34967221)
45. Hauck L, Kaba RG, Lipp M, Dietz R, von Harsdorf R. Regulation of E2F1-dependent gene transcription and apoptosis by the ETS-related transcription factor GABPgamma1. Mol Cell Biol 2002;22: 2147-58. (Pubitemid 34224622)
46. Vottero A, Kino T, Combe H, Lecomte P, Chrousos GP. A novel, Cterminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators. J Clin Endocrinol Metab 2002; 87:2658-67. (Pubitemid 34655327)
47. Newton R, Holden NS. Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Mol Pharmacol 2007;72:799-809. (Pubitemid 47481403)
48. De Bosscher K, Van Craenenbroeck K, Meijer OC, Haegeman G. Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems. Eur J Pharmacol 2008;583:290-302.
49. Weigel NL, Zhang Y. Ligand-independent activation of steroid hormone receptors. J Mol Med (Berl) 1998;76:469-79. (Pubitemid 28261256)
50. Reddy TE, Pauli F, Sprouse RO, Neff NF, Newberry KM, Garabedian MJ, et al. Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res 2009;19:2163-71.
51. Casey TM, Plaut K. The role of glucocorticoids in secretory activation and milk secretion, a historical perspective. J Mammary Gland Biol Neoplasia 2007;12:293-304. (Pubitemid 50003074)
52. Wintermantel TM, Bock D, Fleig V, Greiner EF, Schutz G. The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production. Mol Endocrinol 2005; 19:340-9. (Pubitemid 40223459)
53. Hoijman E, Rocha-Viegas L, Kalko SG, Rubinstein N, Morales-Ruiz M, de Kier Joffe EB, et al. Glucocorticoid alternative effects on proliferating and differentiated mammary epithelium are associated to opposite regulation of cell-cycle inhibitor expression. J Cell Physiol 2012;227:1721-30.
54. Deng CX. Tumor formation in Brca1 conditional mutant mice. Environ Mol Mutagen 2002;39:171-7.