Tumor formation in Brca1 conditional mutant mice

Environmental and Molecular Mutagenesis

Volumn 39, Issue 2-3, 2002, Pages 171-177

  Deng, Chu Xia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Brca1; C neu; Cyclin D1; P53; Tumorigenesis

Indexed keywords

CRE RECOMBINASE; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MYC PROTEIN; PROTEIN; PROTEIN P16; PROTEIN P27; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; BREAST CANCER; CARCINOGENESIS; CELL PROLIFERATION; CONFERENCE PAPER; EMBRYO; EMBRYO DEATH; EPITHELIUM CELL; EXON; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; HISTOPATHOLOGY; LETHALITY; MOUSE; NONHUMAN; ONCOGENE; OVARY CANCER; PROTEIN EXPRESSION; STOCHASTIC MODEL;

ANIMALS; BRCA1 PROTEIN; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE DELETION; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, KNOCKOUT; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MOUSE MAMMARY TUMOR VIRUS;

EID: 0036208277     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10069     Document Type: Conference Paper

References (30)

1. Epidemiology, prevention, and early detection of breast cancer
2. Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis
3. Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis
4. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
5. p53 mutations in BRCA1-associated familial breast cancer
6. p53 mutation as a genetic trait of typical medullary breast carcinoma
7. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
8. Roles of BRCA1 and its interacting proteins
9. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
10. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
11. Linkage of early-onset familial breast cancer to chromosome 17q21
12. A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage
13. Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci
14. New complexities for BRCA1 and BRCA2
15. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
16. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice
17. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
18. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
19. Tumorigenesis in mice carrying a truncating Brca1 mutation
20. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
21. Brca1 controls homology-directed DNA repair
22. "Other" breast cancer susceptibility genes: Searching for more holy grail
23. BRCA1: A review of structure and putative functions
24. Association of BRCA1 with Rad51 in mitotic and meiotic cells
25. A targeted disruption of the murine Brca1 gene causes γ-radiation hypersensitivity and genetic instability
26. Cre-mediated gene deletion in the mammary gland
27. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
28. Centrosome amplification and a detective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
29. Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches
30. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis