Regulation of E2F1-dependent gene transcription and apoptosis by the ETS-related transcription factor GABPγ1

Molecular and Cellular Biology

Volumn 22, Issue 7, 2002, Pages 2147-2158

  Hauck, Ludger ^a   Kaba, Rudolf G ^a   Lipp, Martin ^a   Dietz, Rainer ^a   Von Harsdorf, Rüdiger ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; PROTEIN P130; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR GABPGAMMA1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL STRAIN COS7; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSFECTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NORTHERN BLOTTING; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; IN SITU NICK-END LABELING; MYOCARDIUM; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0036122493     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.7.2147-2158.2002     Document Type: Article

References (50)

1. The structure of GABPalpha/beta: An ETS domain-ankyrin repeat heterodimer bound to DNA
2. Retinoblastoma protein recruits histone deacetylase to repress transcription
3. Cumulative effect of phosphorylation of pRB on regulation of E2F activity
4. Serum-induced expression of the cdc25A gene by relief of E2F-mediated repression
5. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
6. Molecular and genetic characterization of GABP beta
7. The regulation of E2F by pRB-family proteins
8. Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter
9. Inner workings of a transcription factor partnership
10. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
11. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
12. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation
13. E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis
14. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
15. Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1
16. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
17. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
18. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
19. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription
20. Adenovirus E1A represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative pocket protein- and p300-binding domains
21. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
22. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
23. Cyclin A-kinase regulation of E217-1 DNA binding function underlies suppression of an S phase checkpoint
24. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart
25. Apoptotic and growth-promoting activity of E2F modulated by MDM2
26. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
27. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
28. Apaf-1 is a transcriptional target for E2F and p53
29. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
30. The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle
31. Induction of DNA synthesis and apoptosis are separable functions of E2F-1
32. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
33. The transcription factor E2F-1 is a downstream target of RB action
34. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
35. Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein
36. The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family
37. Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation
38. Transcriptional activation through the tetrameric complex formation of E4TF1 subunits
39. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
40. Activation of the retinoblastoma gene expression by Bcl-3: Implication for muscle cell differentiation
41. Functional interactions of transcription factor human GA-binding protein subunits
42. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
43. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
44. E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I
45. Ets transcription factors: Nuclear effectors of the Ras-MAP-kinase signaling pathway
46. Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4
47. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs
48. Mechanism of active transcriptional repression by the retinoblastoma protein
49. In vivo association of E2F and DP family proteins
50. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells