Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex

Molecular Cancer

Volumn 10, Issue , 2011, Pages

  Thompson, Crista ^a,b   MacDonald, Gwen ^a,b,c   Mueller, Christopher R ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GA BINDING PROTEIN; GA BINDING PROTEIN ALPHA; GA BINDING PROTEIN BETA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF1; UNCLASSIFIED DRUG; MULTIPROTEIN COMPLEX;

ARTICLE; BREAST CANCER; CANCER CELL; CELL DIFFERENTIATION; CELL STRAIN MCF 7; CHROMATIN IMMUNOPRECIPITATION; DNA BINDING; GENE DELETION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; BREAST TUMOR; CELL NUCLEUS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PROMOTER REGION; PROTEIN TRANSPORT; TUMOR CELL LINE;

BASE SEQUENCE; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; FEMALE; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NF-E2-RELATED FACTOR 1; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT;

EID: 79956276136     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-10-62     Document Type: Article

References (46)

1. Boulton SJ. Cellular functions of the BRCA tumour-suppressor proteins. Biochem Soc Trans 2006, 34:633-645.
2. Narod SA, Foulkes WD. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 2004, 4:665-676. 10.1038/nrc1431, 15343273.
3. Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, Dontu G, Wicha MS. BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci USA 2008, 105:1680-1685. 10.1073/pnas.0711613105, 2234204, 18230721.
4. Smalley MJ, Reis-Filho JS, Ashworth A. BRCA1 and stem cells: tumour typecasting. Nat Cell Biol 2008, 10:377-379. 10.1038/ncb0408-377, 18379596.
5. Hosey AM, Gorski JJ, Murray MM, Quinn JE, Chung WY, Stewart GE, James CR, Farragher SM, Mulligan JM, Scott AN, Dervan PA, Johnston PG, Couch FJ, Daly PA, Kay E, McCann A, Mullan PB, Harkin DP. Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer. J Natl Cancer Inst 2007, 99:1683-1694. 10.1093/jnci/djm207, 18000219.
6. O'Donovan PJ, Livingston DM. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 2010, 31:961-967. 10.1093/carcin/bgq069, 20400477.
7. Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009, 15:907-913. 10.1038/nm.2000, 19648928.
8. Turner NC, Reis-Filho JS. Basal-like breast cancer and the BRCA1 phenotype. Oncogene 2006, 25:5846-5853. 10.1038/sj.onc.1209876, 16998499.
9. Lux MP, Fasching PA, Beckmann MW. Hereditary breast and ovarian cancer: review and future perspectives. J Mol Med 2006, 84:16-28. 10.1007/s00109-005-0696-7, 16283147.
10. Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, Bennett LM, Haugen-Strano A, Swensen J, Miki Y. BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994, 266:120-122. 10.1126/science.7939630, 7939630.
11. Papa S, Seripa D, Merla G, Gravina C, Giai M, Sismondi P, Rinaldi M, Serra A, Saglio G, Fazio VM. Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. J Natl Cancer Inst 1998, 90:1011-1012. 10.1093/jnci/90.13.1011, 9665150.
12. van der Looij M, Cleton-Jansen AM, van Eijk R, Morreau H, van Vliet M, Kuipers-Dijkshoorn N, Olah E, Cornelisse CJ, Devilee P. A sporadic breast tumor with a somatically acquired complex genomic rearrangement in BRCA1. Genes Chromosomes Cancer 2000, 27:295-302. 10.1002/(SICI)1098-2264(200003)27:3<295::AID-GCC10>3.0.CO;2-F, 10679919.
13. Thompson ME, Jensen RA, Obermiller PS, Page DL, Holt JT. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet 1995, 9:444-450. 10.1038/ng0495-444, 7795653.
14. Taylor J, Lymboura M, Pace PE, A'hern RP, Desai AJ, Shousha S, Coombes RC, Ali S. An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int J Cancer 1998, 79:334-342. 10.1002/(SICI)1097-0215(19980821)79:4<334::AID-IJC5>3.0.CO;2-W, 9699523.
15. Wilson CA, Ramos L, Villasenor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 1999, 21:236-240. 10.1038/6029, 9988281.
16. Mueller CR, Roskelley CD. Regulation of BRCA1 expression and its relationship to sporadic breast cancer. Breast Cancer Res 2003, 5:45-52. 154136, 12559046.
17. Atlas E, Stramwasser M, Whiskin K, Mueller CR. GA-binding protein alpha/beta is a critical regulator of the BRCA1 promoter. Oncogene 2000, 19:1933-1940. 10.1038/sj.onc.1203516, 10773883.
18. LaMarco K, Thompson CC, Byers BP, Walton EM, McKnight SL. Identification of Ets-and notch-related subunits in GA binding protein. Science 1991, 253:789-792. 10.1126/science.1876836, 1876836.
19. Thompson CC, Brown TA, McKnight SL. Convergence of Ets-and notch-related structural motifs in a heteromeric DNA binding complex. Science 1991, 253:762-768. 10.1126/science.1876833, 1876833.
20. Gugneja S, Virbasius JV, Scarpulla RC. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Mol Cell Biol 1995, 15:102-111. 231915, 7799916.
21. Sawa C, Goto M, Suzuki F, Watanabe H, Sawada J, Handa H. Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation. Nucleic Acids Res 1996, 24:4954-4961. 10.1093/nar/24.24.4954, 146336, 9016666.
22. Evans MJ, Scarpulla RC. NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. Genes Dev 1990, 4:1023-1034. 10.1101/gad.4.6.1023, 2166701.
23. Stampfer MR, Garbe J, Levine G, Lichtsteiner S, Vasserot AP, Yaswen P. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci USA 2001, 98:4498-4503. 10.1073/pnas.071483998, 31863, 11287649.
24. MacDonald G, Stramwasser M, Mueller CR. Characterization of a negative transcriptional element in the BRCA1 promoter. Breast Cancer Res 2007, 9:R49. 10.1186/bcr1753, 2206725, 17663789.
25. Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M, Handa H. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. Mol Cell Biol 1993, 13:1385-1391. 359448, 8441384.
26. Virbasius CA, Virbasius JV, Scarpulla RC. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev 1993, 7:2431-2445. 10.1101/gad.7.12a.2431, 8253388.
27. Asangani IA, Rasheed SA, Leupold JH, Post S, Allgayer H. NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene. Gene 2008, 410:197-206. 10.1016/j.gene.2007.12.009, 18234454.
28. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45. 10.1093/nar/29.9.e45, 55695, 11328886.
29. Yoshikawa K, Honda K, Inamoto T, Shinohara H, Yamauchi A, Suga K, Okuyama T, Shimada T, Kodama H, Noguchi S, Gazdar AF, Yamaoka Y, Takahashi R. Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases. Clin Cancer Res 1999, 5:1249-1261.
30. Amirrad M, Al-Mulla F, Varadharaj G, John B, Saji T, Anim JT. BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters. Med Princ Pract 2005, 14:67-72. 10.1159/000083913, 15785095.
31. Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 2008, 88:611-638. 10.1152/physrev.00025.2007, 18391175.
32. Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C. The structure of GABPalpha/beta: an ETS domain-ankyrin repeat heterodimer bound to DNA. Science 1998, 279:1037-1041. 10.1126/science.279.5353.1037, 9461436.
33. Patton J, Block S, Coombs C, Martin ME. Identification of functional elements in the murine Gabp alpha/ATP synthase coupling factor 6 bi-directional promoter. Gene 2006, 369:35-44.
34. Ristevski S, O'Leary DA, Thornell AP, Owen MJ, Kola I, Hertzog PJ. The ETS transcription factor GABPalpha is essential for early embryogenesis. Mol Cell Biol 2004, 24:5844-5849. 10.1128/MCB.24.13.5844-5849.2004, 480913, 15199140.
35. Valouev A, Johnson DS, Sundquist A, Medina C, Anton E, Batzoglou S, Myers RM, Sidow A. Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat Methods 2008, 5:829-834. 10.1038/nmeth.1246, 2917543, 19160518.
36. De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K. Transcriptional autoregulation by BRCA1. Cancer Res 2010, 70:532-542. 10.1158/0008-5472.CAN-09-1477, 2952428, 20068145.
37. Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond) 2005, 29(Suppl 1):S5-S9.
38. Xue HH, Jing X, Bollenbacher-Reilley J, Zhao DM, Haring JS, Yang B, Liu C, Bishop GA, Harty JT, Leonard WJ. Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function. Mol Cell Biol 2008, 28:4300-4309. 10.1128/MCB.01855-07, 2447136, 18426908.
39. Huo L, Scarpulla RC. Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Mol Cell Biol 2001, 21:644-654. 10.1128/MCB.21.2.644-654.2001, 86640, 11134350.
40. Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS, Clayton DA. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 1998, 18:231-236. 10.1038/ng0398-231, 9500544.
41. Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev 1996, 10:1835-1843. 10.1101/gad.10.14.1835, 8698242.
42. Kinoshita K, Ura H, Akagi T, Usuda M, Koide H, Yokota T. GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells. Biochem Biophys Res Commun 2007, 353:686-691. 10.1016/j.bbrc.2006.12.071, 17194449.
43. Joung JG, Shin D, Seong RH, Zhang BT. Identification of regulatory modules by co-clustering latent variable models: stem cell differentiation. Bioinformatics 2006, 22:2005-2011. 10.1093/bioinformatics/btl343, 16899491.
44. Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 2008, 13:472-482. 10.1016/j.ccr.2008.05.005, 18538731.
45. Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007, 110:3056-3063. 10.1182/blood-2007-05-087759, 2018677, 17595331.
46. Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria in cancer cells: what is so special about them?. Trends Cell Biol 2008, 18:165-173. 10.1016/j.tcb.2008.01.006, 18296052.