Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3135-3143

  Chao, Bo ^a   Tong, Xian Kun ^a   Tang, Wei ^a   Li, De Wen ^a   He, Pei Lan ^a   Garcia, Jean Michel ^b   Zeng, Li Min ^a   Gao, An Hui ^a   Yang, Li ^a   Li, Jia ^a   Nan, Fa Jun ^a   Jacobs, Michael ^c   Altmeyer, Ralf ^b   Zuo, Jian Ping ^a   Hu, You Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b HKU PASTEUR RESEARCH CENTRE   (Hong Kong)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOQUINAZOLINE DERIVATIVE; 5 METHOXYQUINAZOLINE 2,4 DIAMINE; 5 TERT BUTOXYQUINAZOLINE 2,4 DIAMINE; LEAD; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; DENGUE VIRUS 2; NONHUMAN; RAT; REPLICON; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

EID: 84859791780     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2015952     Document Type: Article

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