A heterocyclic molecule with significant activity against dengue virus

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 5, 2009, Pages 1425-1427

  Nair, Vasu ^a   Chi, Guochen ^a   Shu, Qingning ^a   Julander, Justin ^b   Smee, Donald F ^b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UTAH STATE UNIVERSITY   (United States)

Author keywords

Antiviral; Dengue; Heterocycle; Inhibitor; Mechanism; Synthesis

Indexed keywords

1,3 DIBENZYL 5 HYDROXY 2,4 DIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 6 CARBOXYLIC ACID; AMINO ACID; ANTIVIRUS AGENT; INOSINATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING KINETICS; CHEMICAL INTERACTION; DENGUE VIRUS; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; FLAVIVIRUS; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; RNA VIRUS; VIRUS INHIBITION; YELLOW FEVER FLAVIVIRUS;

ANTIVIRAL AGENTS; CATALYTIC DOMAIN; DENGUE VIRUS; HETEROCYCLIC COMPOUNDS; IMP DEHYDROGENASE; PROTEIN BINDING;

DENGUE VIRUS; FLAVIVIRUS; RNA VIRUSES; YELLOW FEVER VIRUS;

EID: 60449109722     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.031     Document Type: Article

References (27)

1. Halstead S.B. Science 239 (1988) 476
2. Ooi E., Goh K., and Gubler D.J. Emerg. Infect. Dis. 12 (2006) 887
3. Thomas S.J., Strickman D., and Vaughn D.W. Adv. Virus Res. 61 (2003) 235
4. Clyde K., Kyle J.L., and Harris E. J. Virol. 80 (2006) 11418
5. Melino S., and Paci M. FEBS J. 274 (2007) 2986
6. Chu J.J.H., and Yang P.L. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 3520
7. Rawlinson S.M., Pryor M.J., Wright P.J., and Jans D.A. Curr. Drug Targets 7 (2006) 1623
8. Anderson G.L. J. Heterocycl. Chem. 22 (1985) 1469
9. Heber D., Ravens U., and Shulze T. Pharmazie 48 (1993) 509
10. Papesch V., and Schroeder E.F. J. Org. Chem. 16 (1951) 1879
11. + 404.1246, found 404.1244.
12. + 403.1294, found 403.1297.
13. 90).
14. Sintchak M.D., and Nimmesgern E.I. Immunopharmacology 47 (2000) 163
15. Kerr K.M., Digits J.A., Kuperwasser N., and Hedstrom L. Biochemistry 39 (2000) 9804
16. Colby T.D., Vanderveen K., Strickler M.D., Markham G.D., and Goldstein B.M. Proc. Natl. Acad. Sci. .U.S.A. 96 (1999) 3531
17. Franchetti P., and Grifantini M. Curr. Med. Chem. 6 (1999) 599
18. Goldstein B.M., and Colby T.D. Curr. Med. Chem. 6 (1999) 519
19. Shu Q., and Nair V. Med. Res. Rev. 28 (2008) 219
20. Nair V., and Shu Q. Antiviral Chem. Chemother. 18 (2007) 245
21. Nair V., and Kamboj R.C. Bioorg. Med. Chem. Lett. 13 (2003) 645
22. Nair V., Bonsu E., Gupta M., and Story S. Antiviral Res. 65 (2005) A67
23. Leyssen P., Balzarini J., DeClercq E., and Neyts J. J. Virol. 79 (2005) 1943
24. Sintchak M.D., Fleming M.A., Futer O., Raybuck S.A., Chambers S.P., Caron P.R., Murcko M.A., and Wilson K.P. Cell 85 (1996) 921
25. Diamond M.S., Zachariah M., and Harris E. Virology 304 (2002) 211
26. Neyts J., Meerbach A., McKenna P., and De Clercq E. Antiviral Res. 30 (1996) 125
27. Morrey J.D., Smee D.F., Sidwell R.W., and Tseng C. Antiviral Res. 55 (2002) 107