High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 15, 2003, Pages 2493-2496

  Zolli Juran, Michela ^a   Cechetto, Jonathan D ^a   Hartlen, Rebecca ^a,b   Daigle, Denis M ^a   Brown, Eric D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b Thermo CRS   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIHYDROFOLIC ACID; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FOLIC ACID; FOLIC ACID ANTAGONIST; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PEPTIDE LIBRARY;

ARTICLE; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CONFORMATION; DRUG ACTIVITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR BIOLOGY; SYNTHESIS;

ESCHERICHIA COLI;

EID: 0038309300     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00480-3     Document Type: Article

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