Synthesis of highly functionalized 2,4-diaminoquinazolines as anticancer and anti-HIV agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4432-4435

  Yan, Sheng Jiao ^a   Zheng, Han ^a   Huang, Chao ^a   Yan, Yu Yun ^a   Lin, Jun ^a  

^a YUNNAN UNIVERSITY   (China)

Author keywords

Anti HIV activity; Anticancer activity; Polyhalo 2,4 diaminoquinazoline; Polyhaloisophthalonitrile; Solvent free synthesis

Indexed keywords

2,4 DIAMINOQUINAZOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CISPLATIN;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CELL STRAIN HEPG2; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; IN VITRO STUDY; TUMOR CELL LINE;

ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR CONFORMATION; NEOPLASMS; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77955429246     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.056     Document Type: Article

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