Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 4056-4066

  Schormann, Norbert ^a   Velu, Sadanandan E ^b   Murugesan, Srinivasan ^b   Senkovich, Olga ^a   Walker, Kiera ^a   Chenna, Bala C ^b   Shinkre, Bidhan ^b   Desai, Amar ^a   Chattopadhyay, Debasish ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Antifolate; Chagas disease; Crystal structure; DHFR; Drug development; Kinetoplast; Parasitic disease; Protozoan; Trypanosoma cruzi

Indexed keywords

4 (5 [(2,4 DIAMINO 6 QUINAZOLINYL)METHYL]AMINO 2 METHOXYPHENOXY)BUTANOIC ACID; 6 [(3,4 DIMETHOXYANILINO)METHYL] 2,4 QUINAZOLINEDIAMINE; DIHYDROFOLATE REDUCTASE INHIBITOR; ETHYL 4 (5 [(2,4 DIAMINO 6 QUINAZOLINYL)METHYL]AMINO 2 METHOXYPHENOXY) BUTANOATE; METHYL 4 [(5 [(2,4 DIAMINO 6 QUINAZOLINYL)METHYL]AMINO 2 METHOXYPHENOXY)METHYL]BENZENE CARBOXYLATE; METHYL 5 (5 [(2,4 DIAMINO 6 QUINAZOLINYL)METHYL]AMINO 2 METHOXYPHENOXY)PENTANOATE; METHYL 5 {5 [(3 CYANO 4 FLUOROBENZYL)(PROPYL)AMINO] 2 METHOXYPHENOXY}PENTANOATE; METHYL 5 {5 [[(2,4 DIAMINO 6 QUINAZOLINYL)METHYL](PROPYL)AMINO] 2 METHOXYPHENOXY}PENTANOATE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALCULATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR DOCKING; NONHUMAN; SYNTHESIS; TRYPANOSOMA CRUZI;

CHAGAS DISEASE; COMPUTER SIMULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; PROTEIN BINDING; QUINAZOLINES; TETRAHYDROFOLATE DEHYDROGENASE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA CRUZI;

EID: 77953132056     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.020     Document Type: Article

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