Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 13137-13158

  Geczy, Tamas ^a   Peach, Megan L ^b   Kazzouli, Saïd El ^b   Sigano, Dina M ^b   Kang, Ji Hye ^b   Valle, Christopher J ^a   Selezneva, Julia ^a   Woo, Wonhee ^a   Kedei, Noemi ^a   Lewin, Nancy E ^a   Garfield, Susan H ^a   Lim, Langston ^a   Mannan, Poonam ^a   Marquez, Victor E ^b   Blumberg, Peter M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CLEFTS; BINDING COMPLEXES; BINDING POCKETS; C1 DOMAIN; COMPUTER MODELING; DIACYLGLYCEROL; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HIGH POTENCY; HOMOLOGY DOMAIN; INITIAL DESIGN; MEMBRANE ASSOCIATION; MOLECULAR BASIS; PHORBOL ESTERS; SECOND MESSENGER;

ESTERIFICATION; ESTERS; GLYCEROL;

LIGANDS;

DIACYLGLYCEROL; MUTANT PROTEIN; PHORBOL ESTER; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG; VAV PROTEIN; VAV1 PROTEIN;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COMPUTER MODEL; CONTROLLED STUDY; GEOCHEMISTRY; HUMAN; HUMAN CELL; HYDROPHILICITY; LIGAND BINDING; LIPOPHILICITY; MEMBRANE BINDING; MEMBRANE TRANSPORT; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; POINT MUTATION; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; DIGLYCERIDES; HUMANS; LACTONES; LIGANDS; MALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHORBOL ESTERS; PHOSPHOLIPIDS; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN KINASE C-DELTA; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-VAV; SIGNAL TRANSDUCTION;

EID: 84859776731     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.320010     Document Type: Article

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