Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation

Molecular and Cellular Biology

Volumn 22, Issue 8, 2002, Pages 2487-2497

  Booden, Michelle A ^a   Campbell, Sharon L ^a   Der, Channing J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GENE PRODUCT; GUANINE; GUANOSINE TRIPHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLECKSTRIN; PROTEIN DDL; PROTEIN VAV2; RHO FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVITY; GENE MUTATION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BLOOD PROTEINS; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; PHOSPHOPROTEINS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-VAV; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFORMATION, GENETIC;

ANIMALIA;

EID: 0036210706     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.8.2487-2497.2002     Document Type: Article

References (45)

1. Vav2 is an activator of Cdc42, Rac1, and RhoA
2. Involvement of N-terminal sequences in the negative regulation of vav signaling and transforming activity
3. Rho GTPases and their effector proteins
4. Two distinct Raf domains mediate interaction with Ras
5. Activation of the cellular proto-oncogene product p21 Ras by addition of a myristylation signal
6. The VAV family of signal transduction molecules
7. Regulatory and signaling properties of the Vav family
8. The Dbl family of oncogenes
9. Biological assays for Ras transformation
10. 14-3-3 Zeta negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain
11. Mechanism of activation of the vav protooncogene
12. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
13. Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation
14. Mammalian expression vectors for ras family proteins: Generation and use of expression constructs to analyze Ras family function
15. Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras
16. The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-Ras
17. Lck regulates Vav activation of members of the Rho family of GTPases
18. Role of substrates and products of P1 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
19. Signaling and subcellular targeting by membrane-binding domains
20. Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential
21. Signal-dependent membrane targeting by pleckstrin homology (PH) domains
22. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
23. Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not β1 integrins
24. NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio
25. An intact Raf zinc finger is required for optimal binding to processed Ras and for Ras-dependent Raf activation in situ
26. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase γ, a Rac guanosine exchange factor, and Rac
27. The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site
28. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
29. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
30. Distinct roles for DH and PH domains in the Lbc oncogene
31. βγ subunits and lipid
32. A phorbol ester binding domain of protein kinase Cζ
33. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
34. Bacterial expressed DH and DH/PH domains
35. Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2
36. Competitive inhibition by diacylglycerol of specific phorbol ester binding
37. Rho GTPases and signaling networks
38. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
39. Dbl family proteins
40. Expression cloning of oncogenes by retroviral transfer of cDNA libraries
41. Dependence of Dbl and Dbs transformation on MEK and NF-KB activation
42. Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions
43. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
44. Guanine nucleotide exchange catalyzed by dbl oncogene product
45. Rho family proteins and Ras transformation: The RHOad less traveled gets congested