Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system

Journal of Virology

Volumn 74, Issue 12, 2000, Pages 5604-5618

  Palmer, J A ^a,b   Branston, R H ^a   Lilley, C E ^a   Robinson, M J ^a   Groutsi, F ^a   Smith, J ^a   Latchman, D S ^a   Coffin, R S ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Neurovex Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; GENE DELETION; GENE EXPRESSION; GENE TARGETING; HERPES SIMPLEX VIRUS; MOUSE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROMOTER REGION; SAFETY; SPINAL GANGLION;

ANIMALS; CELL LINE; CRICETINAE; GANGLIA, SPINAL; GENE DELETION; GENE EXPRESSION REGULATION, VIRAL; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC ENGINEERING; GENETIC MARKERS; GENETIC VECTORS; GENOME, VIRAL; HERPES SIMPLEX VIRUS PROTEIN VMW65; HINDLIMB; INJECTIONS; MOTOR NEURONS; PERIPHERAL NERVOUS SYSTEM; PROMOTER REGIONS (GENETICS); SCIATIC NERVE; SIMPLEXVIRUS; TIME FACTORS; VIRAL PROTEINS; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0034076866     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.12.5604-5618.2000     Document Type: Article

References (45)

1. Ace, C. I., T. A. McKee, M. Ryan, J. M. Cameron, and C. M. Preston. 1989. Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression. J. Virol. 63:2260-2269.
2. Balan, P., N. Davispoynter, S. Bell, H. Atkinson, H. Browne, and T. Minson. 1994. An analysis of the in vitro and in vivo phenotypes of mutants of herpes-simplex virus type 1 lacking glycoproteins gG, gE, gI or the putative gJ. J. Gen. Virol. 75:1245-1258.
3. Bloom, D. C., N. T. Maidment, A. Tan, V. B. Dissette, L. T. Feldman, and J. G. Stevens. 1995. Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus. Mol. Brain Res. 31:48-60.
4. Carpenter, D. E., and J. G. Stevens. 1996. Long-term expression of a foreign gene from a unique position in the latent herpes simplex virus genome. Hum. Gene Ther. 7:1447-1454.
5. Coffin, R. S., M. K. Howard, and D. S. Latchman. 1995. Altered dinucleotide content within the latently transcribed regions of the DNA of alpha herpes viruses - implications for latent RNA expression and DNA structure. Virology 209:358-365.
6. Coffin, R. S., and D. S. Latchman. 1995. Herpes simplex virus based vectors, p. 99-112. In D. S. Latchman (ed.), Genetic manipulation of the nervous system. Academic Press, London, United Kingdom.
7. Coffin, R. S., A. R. Maclean, D. S. Latchman, and S. M. Brown. 1996. Gene delivery to the central and peripheral nervous systems of mice using HSV1 ICP34.5 deletion mutant vectors. Gene Ther. 3:886-891.
8. Deshmane, S. L., and N. W. Fraser. 1989. During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J. Virol. 63:943-947.
9. Dobson, A. T., T. P. Margolis, W. A. Gomes, and L. T. Feldman. 1995. In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter. J. Virol. 69:2264-2270.
10. Dobson, A. T., T. P. Margolis, F. Sederati, J. G. Stevens, and L. T. Feldman. 1990. A latent, non-pathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons. Neuron 5:353-360.
11. Ecob-Prince, M. S., K. Hassan, M. T. Denheen, and C. M. Preston. 1995. Expression of β-galactosidase in neurons of dorsal root ganglia which are latently infected with herpes simplex virus type 1. J. Gen. Virol. 76:1527-1532.
12. Ecob-Prince, M. S., F. J. Rixon, C. M. Preston, K. Hassan, and P. G. E. Kennedy. 1993. Reactivation in vivo and in vitro of herpes simplex virus from mouse dorsal root ganglia which contain different levels of latency-associated transcripts. J. Gen. Virol. 74:995-1002.
13. Fink, D. J., N. A. Deluca, W. F. Goins, and J. C. Glorioso. 1996. Gene transfer to neurons using herpes simplex virus vectors. Annu. Rev. Neurosci. 19:265-287.
14. Forss-Petters, S., P. E. Danielson, S. Catsicas, E. Battenberg, J. Price, M. Nerenberg, and J. G. Sutcliffe. 1990. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 5:187-197.
15. Goins, W. F., L. R. Sternberg, K. D. Croen, P. R. Krause, R. L. Hendricks, D. J. Fink, S. E. Straus, M. Levine, and J. C. Glorioso. 1994. A novel latency active promoter is contained within the herpes simplex type 1 UL flanking repeats. J. Virol. 68:2239-2252.
16. Goldstein, D. J., and S. K. Weller. 1988. Herpes simplex virus type-1 -induced ribonucleotide reductase activity is dispensible for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant. J. Virol. 62:196-205.
17. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
18. Ho, D. Y., and E. S. Mocarski. 1988. β-Galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse. Virology 167:279-283.
19. Johnson, P. A., A. Miyanohara, F. Levine, T. Cahill, and T. Friedman. 1992. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J. Virol. 66:2952-2965.
20. Johnson, P. A., M. J. Wang, and T. Friedman. 1994. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J. Virol. 68:6347-6362.
21. Krisky, D. M., D. Wolfe, W. F. Goins, P. C. Marconi, R. Ramakrishnan, M. Mata, R. J. D. Rouse, D. J. Fink, and J. C. Glorioso. 1998. Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long term gene expression in neurons. Gene Ther. 5:1593-1603.
22. Lachmann, R. H., C. Brown, and S. Efstathiou. 1996. A murine RNA polymerase 1 promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection. J. Gen. Virol. 77:2575-2582.
23. Lachmann. R. H., and S. Efstathiou. 1997. Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system. J. Virol. 71:3197-3207.
24. Leib, D. A., D. M. Coen, C. L. Bogard, K. A. Hicks, D. R. Yager, D. Knipe, K. L. Tyler, and P. A. Schaffer. 1989. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J. Virol. 63:759-768.
25. Lokensgard, J. R., D. C. Bloom, A. T. Dobson, and L. T. Feldman. 1994. Long-term promoter activity during herpes simplex virus latency. J. Virol. 68:7148-7158.
26. Lokensgard, J. R., H. Berthomme, and L. T. Feldman. 1997. The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency. J. Virol. 71:6714-6719.
27. Maclean, A. R., M. Ul-Fareed, L. Robertson, J. Harland, and S. M. Brown. 1991. Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediately early gene 1 and the 'a' sequence. J. Gen. Virol. 72:631-639.
28. Margolis, T. P., D. C. Bloom, A. T. Dobson, L. T. Feldman, and J. G. Stevens. 1993. Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. Virology 197:585-592.
29. Marshall, K. R., R. H. Lachmann, S. Ethstathiou, A. Rinaldi, and C. M. Preston. 2000. Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression. J. Virol. 74:956-964.
30. McFarlane, M., J. I. Daksis, and C. M. Preston. 1992. Hexamethylene bisacetamide stimulates herpes-simplex virus immediate-early gene expression in the absence of trans-induction by VMW65. J. Gen. Virol. 73:285-292.
31. Morgenstern, J. P., and H. Land. 1990. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. 18:1068.
32. Palella, T. D., L. J. Silverman, C. T. Schroll, F. L. Homa, M. Levine, and W. M. Kelley. 1988. Herpes simplex virus-mediated human hypoxanthineguanine phosphoribosyl transferase gene transfer into neuronal cells. Mol. Cell. Biol. 8:457-460.
33. Palmer, J. A., C. De Felipe, J. A. O'Brien, and S. P. Hunt. 1999. Disruption of the substance P receptor (neurokinin-1) gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation. Eur. J. Neurosci. 11:3531-3538.
34. Price, J., D. Turner, and C. Cepko. 1987. Lineage analysis in the vertebrate nervous system by retrovirus mediated gene transfer. Proc. Natl. Acad. Sci. USA 84:156-160.
35. Robertson, L. M., L. M. Maclean, A. R. Maclean, and S. M. Brown. 1992. Peripheral replication and latency reactivation kinetics of the non-neurovirulent herpes-simplex virus type-1 variant-1716. J. Gen. Virol. 73:967-970.
36. Rodahl, E., and L. Haarr. 1997. Analysis of the 2-kilobase latency associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable nonlinear structure. J. Virol. 71:1703-1707.
37. Samaniego, L. A., L. Neiderhiser, and N. A. Deluca. 1998. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J. Virol. 72:3307-3320.
38. Stevens, J. G., E. K. Wagner, G. B. Devi-Rao, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus a gene mRNA is prominent in latently infected neurons. Science 235:1056-1059.
39. Strelow, L. I., and D. A. Leib. 1995. Role of the virion host shutoff (VHS) protein of herpes simplex virus type-1 in latency and pathogenesis. J. Gen. Virol. 69:6779-6786.
40. Thomas, S. K., C. E. Lilley, D. S. Latchman, and R. S. Coffin. 1999. Equine herpesvirus 1 gene 12 can substitute for vmw65 in the growth of herpes simplex virus (HSV) type 1, allowing the generation of optimized cell lines for the propagation of HSV vectors with multiple immediate-early gene defects. J. Virol. 73:7399-7409.
41. Twyman, R. M., and E. A. Jones. 1997. Sequences in the proximal 5′ flanking region of the rat neuron-specific enolase (NSE) gene are sufficient for cell type-specific reporter gene expression. J. Mol. Neurosci. 8:63-73.
42. Wagstaff, M. J. D., C. E. Lilley, J. Smith, M. J. Robinson, R. S. Coffin, and D. S. Latchman. 1998. Gene transfer using a disabled herpes virus vector containing the EMCV IRES allows multiple gene expression in vitro and in vivo. Gene Ther. 5:1566-1570.
43. Wilson, S. P., D. C. Yeomans, M. A. Bender, Y. Lu, W. F. Goins, and J. C. Glorioso. 1999. Antihyperalgesic effects of infection with preproenkephalin-encoding herpes viruses. Proc. Natl. Acad. Sci. USA 96:3211-3216.
44. Wu, N., S. C. Watkins, P. A. Schaffer, and N. A. Deluca. 1996. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J. Virol. 70:6358-6369.
45. Wu, T.-T., Y.-H. Su, T. M. Block, and J. M. Taylor. 1996 Evidence that two latency-associated transcripts of herpes simplex virus are nonlinear. J. Virol. 70:5962-5967.