Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain

Pain

Volumn 102, Issue 1-2, 2003, Pages 135-142

  Hao, Shuanglin ^a   Mata, Marina ^a,c   Goins, William ^b   Glorioso, Joseph C ^b   Fink, David J ^a,b,c,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d NONE   (United States)

Author keywords

Gene transfer; Herpes simplex virus; Morphine; Pain; Tolerance

Indexed keywords

ENKEPHALIN; MORPHINE; NALOXONE; OPIATE PEPTIDE; PROTEIN C FOS; VIRUS VECTOR;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG TOLERANCE; GENE TRANSFER; HERPES SIMPLEX VIRUS; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SPINAL CORD; SPINAL CORD DORSAL HORN; TRANSGENE;

EID: 0037333714     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0304-3959(02)00346-9     Document Type: Article

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