Topical agents for the treatment of chronic pain

Current Pain and Headache Reports

Volumn 10, Issue 1, 2006, Pages 11-19

  Argoff, Charles E ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANALGESIC AGENT; CAMPHOR; CANNABINOID; CAPSAICIN; CHONDROITIN SULFATE; DICLOFENAC; DOXEPIN; ELTENAC; EMLA; FLURBIPROFEN; GERANIUM OIL; GLUCOSAMINE SULFATE; GLUTAMATE RECEPTOR ANTAGONIST; IBUPROFEN; KETAMINE; KETOPROFEN; LIDOCAINE; LOCAL ANESTHETIC AGENT; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PLACEBO; RUBEFACIENT; SALICYLIC ACID; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; VEGETABLE OIL;

ANALGESIC ACTIVITY; CHRONIC PAIN; CLINICAL TRIAL; COMPLEX REGIONAL PAIN SYNDROME TYPE I; DRUG ABSORPTION; DRUG MECHANISM; GASTROINTESTINAL SYMPTOM; HUMAN; NEUROPATHIC PAIN; NOCICEPTION; PAIN; POSTHERPETIC NEURALGIA; REVIEW;

ADMINISTRATION, TOPICAL; AGED; ANESTHETICS, LOCAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAPSAICIN; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN;

EID: 33645067653     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-006-0004-4     Document Type: Review

References (80)

1. Argoff CE: New analgesics for neuropathic pain: the lidocaine patch. Clin J Pain 2000, 16 (suppl): S62-S65.
2. Argoff CE: Topical treatments for pain. Curr Pain Headache Rep 2004, 8:261-267.
3. Argoff CE: Targeted topical peripheral analgesics in the management of pain. Curr Pain Headache Rep 2002, 7:34-38.
4. Galer BS: Topical medications. In Bonica's Management of Pain. Edited by Loeser JD. Philadelphia: Lippincott-Williams & Wilkins; 2001:1736-1741.
5. Gammaitoni AR, Alvarez NA: 24-hour application of the lidocaine patch 5% for 3 consecutive days is safe and well tolerated in healthy adult men and women [Abstract PO6.20]. Presented at the 54th Annual American Academy of Neurology Meeting. Denver: April 13-20, 2002.
6. Argoff C, Nicholson B, Moskowitz M, et al.: Effectiveness of lidocaine patch 5% (Lidoderm®) in the treatment of low back pain. Presented at the 10th World Congress on Pain. San Diego: August 17-22, 2002.
7. Watson CP: Topical capsaicin as an adjuvant analgesic. J Pain Symptom Manage 1994, 9:425-433.
8. Gammaitoni AR, Davis MW: Pharmacokinetics and tolerability of lidocaine 5% patch with extended dosing. Ann Pharmacother 2002, 36:236-240.
9. Ness TJ, Jones L, Smith H: Use of compounded topical analgesics- results of an Internet survey. Reg Anesth Pain Med 2002, 27:309-312.
10. Sawynok J: Topical and peripherally acting analgesics. Pharmacol Rev 2003, 55:1-20.
11. Robbins W: Clinical applications of capsaicinoids. Clin J Pain 2000, 16(suppl):S86-S89.
12. Bley KR: Recent developments in transient receptor potential vanilloid receptor 1 agonist based therapy. Expert Opin Investig Drugs 2004, 13:1445-1456.
13. Rowbotham MC: Topical analgesic agents. In Pharmacologic Approaches to the Treatment of Chronic Pain: New Concepts and Critical Issues. Edited by Fields HL, Liebeskind JC. Seattle: IASP Press; 1994:211-227.
14. Cashman JN: The mechanism of action of NSAIDs in analgesia. Drugs 1996, 52(suppl 5):13-23.
15. Yesilyurt O, Dogrul A, Gul H, et al.: Topical cannabinoid enhances topical morphine antinociception. Pain 2003, 105:303-308.
16. Sawynok J, Esser MJ, Reid AR: Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J Psychiatry Neurosci 2001, 26:21-29.
17. Gerner P, Kao G, Srinivasa V, et al.: Topical amitriptyline in health volunteers. Reg Anesth Pain Med 2003, 28:289-293.
18. Physicians Desk Reference, edn 55. Montvale, NJ: Medical Economics Company; 2002.
19. Sawynok J: Topical analgesics in neuropathic pain. Curr Pharm Des 2005, 11:2995-3004.
20. Rowbotham MC, Davies PS, Verkempinck, et al.: Lidocaine patch: double-blind, controlled study of a new treatment method for post-herpetic neuralgia. Pain 1996, 65:39-44.
21. Galer BS, Rowbotham MC, Perander J, et al.: Topical lidocaine patch relieves post-herpetic neuralgia more effectively than vehicle patch: results of an enriched enrollment study. Pain 1999, 80:533-538.
22. Katz NP, Davis MW, Dworkin RH: Topical lidocaine patch produces a significant improvement in mean pain scores and pain relief in treated PHN patients: results of a multicenter, open-label trial. J Pain 2001, 2:9-18.
23. Meier T, Wasner G, Faust M, et al.: Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study. Pain 2003, 106:151-158.
24. Devers A, Galer BS: Topical lidocaine patch relieves a variety of neuropathic pain conditions: an open-label study. Clin J Pain 2000, 16:205-208.
25. Data on file. Endo Pharmaceuticals, Inc. Chadds Ford, PA.
26. Hart-Gouleau S, Cammaitoni A, Galer BS, et al.: Open-label study of the effectiveness and safety of the lidocaine patch 5% (Lidoderm®) in patients with painful diabetic neuropathy. Presented at the 10th World Congress on Pain. San Diego: August 17-22, 2002.
27. Galer BS, Jensen MP: Development and preliminary validation of a pain measure specific to neuropathic pain: the Neuropathic Pain Scale. Neurology 1997, 48:332-338.
28. Barbano RL, Herrmann DN, Hart-Gouleau S, et al.: Effectiveness, tolerability, and impact on quality of life of lidocaine patch 5% in diabetic polyneuropathy. Arch Neurol 2005, in press.
29. Galer BS, Jensen MP, Ma T, et al.: The lidocaine patch 5% effectively treats all neuropathic pain qualities: results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with use of the Neuropathic Pain Scale. Clin J Pain 2002, 18:297-301.
30. Lycka BA, Watson CP, Nevin K, et al.: EMLA® cream for the treatment of pain caused by post-herpetic neuralgia: a double-blind, placebo-controlled study [Abstract]. Proc Am Pain Soc 1996, A111.
31. Attal N, Brasseur L, Chauvin M, et al.: Effects of single and repeated applications of a eutectic mixture of local anesthetics (EMLA®) cream on spontaneous and evoked pain in post-herpetic neuralgia. Pain 1999, 81:203-209.
32. Litman SJ, Vitkun SA, Poppers PJ: Use of EMLA® cream in the treatment of post-herpetic neuralgia. J Clin Anesth 1996, 8:54-57.
33. Lynch ME, Clark AJ, Sawynok J: A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. Clin J Pain 2003, 19:323-328.
34. Quan D, Wellish M, Gilden DH: Topical ketamine treatment of postherpetic neuralgia. Neurology 2003, 60:1391-1392.
35. Greenway FL, Frome BM, Engels TM, et al.: Temporary relief of postherpetic neuralgia pain with topical geranium oil. Am J Med 2003, 115:586-587.
36. Rains C, Bryson HM: Topical capsaicin: a review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy, and osteoarthritis. Drugs Aging 1995, 7:317-328.
37. Robbins WR, Staats PS, Levine J, et al.: Treatment of intractable pain with topical large-dose capsaicin: preliminary report. Anesth Analg 1998, 86:579-583.
38. Backonja M, Malan P, Brady S, et al.: One-hour high concentration trans-capsaicin applications provide durable pain relief in initial and repeat treatment of postherpetic neuralgia. Presented at the Annual Scientific Meeting of the American Academy of Neurology. San Francisco: April 24-May 1, 2004.
39. Simpson D, Brown S, Sampson J, et al.: A single application of high-concentration trans-capsaicin leads to 12 weeks of pain relief in HIV-associated distal symmetrical polyneuropathy: results of an open label trial. Presented at the Annual Scientific Meeting of the American Academy of Neurology. San Francisco: April 24-May 1, 2004.
40. Mason L, Moore RA, Derry S, et al.: Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004, 328:991-996.
41. McCleane G: Topical application of doxepin hydrochloride, capsaicin, and a combination of both produces analgesia in chronic neuropathic pain: a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol 2000, 49:574-579.
42. Lynch ME, Clark AJ, Sawynok J, et al.: Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology 2005, 103:140-146.
43. Lynch ME, Clark AJ, Sawynok J, et al.: Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. J Pain 2005, 6:644-649.
44. Mazieres B, Rouanet S, Velicy J, et al.: Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study. Am J Sports Med 2005, 33:515-523.
45. Mazieres B, Rouanet S, Guillon Y, et al.: Topical ketoprofen patch in the treatment of tendonitis: a randomized, double blind, placebo-controlled study. J Rheumatol 2005, 32:1563-1570.
46. Predel HG, Koll R, Pabst H, et al.: Diclofenac patch for topical treatment of acute impact injuries: a randomized, double-blind, placebo-controlled, multicenter study. Br J Sports Med 2004, 38:318-323.
47. Marten M: Efficacy and tolerability of a topical NSAID patch (local action transcutaneous flurbiprofen) and oral diclofenac in the treatment of soft-tissue rheumatism. Clin Rheumatol 1997, 16:25-31.
48. Galer BS, Rowbotham MC, Perander J, et al.: Topical diclofenac patch significantly reduces pain associated with minor sports injuries: results of a randomized, double-blind, placebo-controlled, multicenter study. J Pain Symptom Manage 2000, 19:287-294.
49. Jenoure P, Segesser B, Luhti U, et al.: A trial with diclofenac HEP plaster as topical treatment in minor sports injuries. Drugs Exp Clin Res 1993, 19:125-131.
50. Campbell J, Dunn T: Evaluation of topical ibuprofen cream in the treatment of acute ankle sprains. J Accidental Emerg Med 1994, 11:178-182.
51. Airaksinen O, Venalainen J, Pietilainen T: Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries. Int J Clin Pharmacol Ther Toxicol 1993, 31:561-563.
52. Machen J, Whitefield M: Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomized, double-blind, placebo-controlled study. Intl J Clin Prac 2002, 56:102-106.
53. Whitefield M, O'Kane CJ, Anderson S: Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study. J Clin Pharm Ther 2002, 27:409-417.
54. Bruhlmann P, Michel BA: Topical diclofenac patch in patients with knee osteoarthritis: a randomized, double-blind, controlled clinical trial. Clin Exp Rheumatol 2003, 21:193-198.
55. Tugwell PS, Wells GA, Shainhouse JZ: Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized, controlled trial. J Rheumtol 2004, 31:2002-2012.
56. Di Rienzo BL, Di Rienzo BA, D'Emilia E, et al.: Topical versus systemic diclofenac in the treatment of temporo-mandibular joint dysfunction symptoms. Acta Otorhinolaryngol Ital 2004, 24:279-283.
57. Lin J, Zhang W, Jones A, et al.: Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomized, controlled trials. BMJ 2004, 329:324-328.
58. Mason L, Moore RA, Edwards JE, et al.: Topical NSAIDS for chronic musculoskeletal pain: a systematic review and meta-anaiysis. BMC Musculoskelet Disord 2004, 5:28.
59. Mason L, Moore RA, Edwards JE, et al.: Systematic review of topical rubefacients containing salicylates for the treatment of acute and chronic pain. BMJ 2004, 328:995.
60. Ottillinger B, Gomor B, Michel BA, et al.: Efficacy and safety of eltenac gel in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 2001, 9:273-280.
61. Sandelin J, Harilainen A, Crone H, et al.: Local NSAID gel (eltenac) in the treatment of osteoarthritis of the knee: a double-blind study comparing eltenac with oral diclofenac and placebo gel. Scand J Rheumatol 1997, 26:287-292.
62. Dreiser RL, Tisne-Camus M: DHEP plasters as a topical treatment of knee osteoarthritis: a double-blind, placebo-controlled study. Drugs Exp Clin Res 1993, 19:107-115.
63. Galeazzi M, Marcolongo R: A placebo-controlled study of the efficacy and tolerability of a nonsteroidal anti-inflammatory drug, DHEP plaster in inflammatory peri- and extra-articular rheumatological diseases. Drugs Exp Clin Res 1993, 19:107-115.
64. Gallachia G, Marcolongo R: Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion. Drugs Exp Clin Res 1993, 19:95-97.
65. Winocur E, Gavish A, Halachmi M, et al.: Topical application of capsaicin for the treatment of localized pain in the temporomandibular joint area. J Orofac Pain 2000, 14:31-36.
66. Cohen M, Wolfe R, Mai T, et al.: A randomized, double-blind, placebo-controlled trial of a topical crème containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol 2003, 30:523-528.
67. Keitel W, Frerick H, Kuhn U, et al.: Capsicum pain plaster in chronic non-specific low back pain. Arzneimittelforschung 2001, 51:896-903.
68. Lipman AG, Dalpiaz AS, London SP: Topical lidocaine patch therapy for myofascial pain [Abstract 782].. Presented at the Annual Scientific Meeting of the American Pain Society. Baltimore: March 14-17, 2002.
69. Briggs M, Nelson EA: Topical agents or dressings for pain in venous leg ulcers. Cochrane Database Syst Rev 2003, 1:CD001177.
70. Flock P: Pilot study to determine the effectiveness of diamorphine gel to control pressure ulcer pain. J Pain Symptom Manage 2003, 25:547-554.
71. Zeppetella G, Ribeiro PJ: Analgesic efficacy of morphine applied topically to painful ulcers. J Pain Symptom Manage 2003, 25:555-558.
72. Gallagher RE, Arndt DR, Hunt KL: Analgesic effects of topical methadone: a report of four cases. Clin J Pain 2005, 21:190-192.
73. Vernassiere C, Cornet C, Trechot P, et al.: Study to determine the efficacy of topical morphine on painful chronic skin ulcers. J Wound Care 2005, 14:289-293.
74. Cerchietti LC, Navigante AH, Bonomi MR, et al.: Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 2002, 95:2230-2236.
75. Slatkin NE, Rhiner M: Topical ketamine in the treatment of mucositis pain. Pain Med 2003, 4:298-303.
76. Watterson G, Howard R, Goldman A: Peripheral opiates in inflammatory pain. Arch Dis Child 2004, 89:679-681.
77. Galeotti N, DeCesare Mannelli L, Mazzanti G, et al.: Menthol: a natural analgesic compound. Neurosci Lett 2002, 322:145-148.
78. Sandroni P: Central neuropathic itch: A new treatment option? Neurology 2002, 59:778-779.
79. Lockhart E: Topical combination of amitriptyline and ketamine for post herpetic neuralgia. J Pain 2004, 1(suppl):82.
80. Bernstein J, Phillips S, Group T. A new topical medication for the adjunctive relief of painful diabetic neuropathy and postherpetic neuralgia. J Pain 2004, 1(suppl): 82.