Update on a pharmacokinetic-centric alternative tier II program for MMT-Part I: Program implementation and lessons learned

Journal of Toxicology

Volumn 2012, Issue , 2012, Pages

  Dorman, David C ^a   Andersen, Melvin E ^b   Roper, Jerry M ^c   Taylor, Michael D ^c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c AFTON CHEMICAL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUEL; MANGANESE; MANGANESE CHLORIDE; MANGANESE OXIDE; MANGANESE SULFATE; METHYLCYCLOPENTADIENYLMANGANESE TRICARBONYL;

AIR; COMBUSTION; DOSIMETRY; ENVIRONMENTAL EXPOSURE; GENDER; GOVERNMENT; HEALTH CARE PLANNING; HEALTH HAZARD; HEALTH PROGRAM; HEPATOBILIARY DISEASE; HUMAN; INFORMATION PROCESSING; NEWBORN PERIOD; NONHUMAN; OLFACTORY NERVE; PHYSIOLOGICAL PROCESS; PREDICTION; PRIORITY JOURNAL; REPRODUCTION; REVIEW; RHESUS MONKEY; RISK ASSESSMENT; SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL; UNITED STATES;

EID: 84859736921     PISSN: 16878191     EISSN: 16878205     Source Type: Journal    
DOI: 10.1155/2012/946742     Document Type: Review

References (61)

1. Pfeifer G. D., Roper J. M., Dorman D., Lynam D. R., Health and environmental testing of manganese exhaust products from use of methylcyclopentadienyl manganese tricarbonyl in gasoline Science of the Total Environment 2004 334-335 397 408 (Pubitemid 39420357)
2. Taylor M. D., Andersen M. E., Schroeter J. D., Yoon M., Keene A. M., Dorman D. C., Update on a pharmacokinetic-centric alternative Tier II program for MMT. Part II. physiologically-based pharmacokinetic modeling and manganese risk assessment. Journal of Toxicology. In press
3. Aschner J. L., Aschner M., Nutritional aspects of manganese homeostasis Molecular Aspects of Medicine 2005 26 4-5 353 362 (Pubitemid 41225358)
4. Agency for Toxic Substances and Disease Registry (ATSDR), Toxicological Profile for Manganese 2008 Atlanta, Ga, USA U.S. Department of Health and Human Services. http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=102tid=23
5. Health Canada, Human Health Risk Assessment for Inhaled Manganese. ISBN: 978-1-100-15221-9, 2010, http://www.hc-sc.gc.ca/ewh-semt/pubs/air/manganese-eng. php
6. U.S. Environmental Protection Agency (USEPA), Integrated Risk Information System (IRIS) Manganese (CASRN 7439-96-5) Reference Concentration for Chronic Inhalation Exposure (RfC) 1993. http://www.epa.gov/iris/subst/0373.htm
7. Guilarte T. R., Manganese and Parkinson's disease: a critical review and new findings Environmental Health Perspectives 2010 118 8 1071 1080
8. Aschner M., Erikson K. M., Hernndez E. H., Tjalkens R., Manganese and its role in Parkinson's disease: from transport to neuropathology NeuroMolecular Medicine 2009 11 4 252 266
9. Santamaria A. B., Sulsky S. I., Risk assessment of an essential element: manganese Journal of Toxicology and Environmental Health A 2010 73 2-3 128 155
10. Roels H. A., Ghyselen P., Buchet J. P., Ceulemans E., Lauwerys R. R., Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust British Journal of Industrial Medicine 1992 49 1 25 34
11. Lucchini R., Apostoli P., Perrone C., Placidi D., Albini E., Migliorati P., Mergler D., Sassine M. P., Palmi S., Alessio L., Long term exposure to low levels of manganese oxides and neurofunctional changes in ferroalloy workers NeuroToxicology 1999 20 2-3 287 298 (Pubitemid 29268572)
12. Bailey L. A., Goodman J. E., Beck B. D., Proposal for a revised Reference Concentration (RfC) for manganese based on recent epidemiological studies Regulatory Toxicology and Pharmacology 2009 55 3 330 339
13. American Conference of Governmental Industrial Hygienists (ACGIH) 2011 TLVs and BEIs,. Publication #0111
14. Pellizzari E. D., Clayton C. A., Rodes C. E., Mason R. E., Piper L. L., Fort B., Pfeifer G., Lynam D., Particulate matter and manganese exposures in Toronto, Canada Atmospheric Environment 1999 33 5 721 734 (Pubitemid 29070977)
15. Clayton C. A., Pellizzari E. D., Rodes C. E., Mason R. E., Piper L. L., Estimating distributions of long-term particulate matter and manganese exposures for residents of Toronto, Canada Atmospheric Environment 1999 33 16 2515 2526 (Pubitemid 29227248)
16. Crump K. S., Manganese exposures in Toronto during use of the gasoline additive, methylcyclopentadienyl manganese tricarbonyl Journal of Exposure Analysis and Environmental Epidemiology 2000 10 3 227 239 (Pubitemid 30463345)
17. Bhuie A. K., Roy D. N., Deposition of Mn from automotive combustion of methylcyclopentadienyl manganese tricarbonyl beside the major highways in the greater Toronto area, Canada Journal of the Air and Waste Management Association 2001 51 9 1288 1301 (Pubitemid 32847867)
18. Gulson B., Mizon K., Taylor A., Korsch M., Stauber J., Davis J. M., Louie H., Wu M., Swan H., Changes in manganese and lead in the environment and young children associated with the introduction of methylcyclopentadienyl manganese tricarbonyl in gasolinePreliminary results Environmental Research 2006 100 1 100 114
19. Gulson B., Mizon K., Taylor A., Korsch M., Stauber J., Davis J. M., Louie H., Wu M., Antin L., Longitudinal monitoring of selected elements in blood of healthy young children Journal of Trace Elements in Medicine and Biology 2008 22 3 206 214
20. Bridbord K., Hanson D., A personal perspective on the initial federal health-based regulation to remove lead from gasoline Environmental Health Perspectives 2009 117 8 1195 1201
21. Davis J. M., Methylcyclopentadienyl manganese tricarbonyl: health risk uncertainties and research directions Environmental Health Perspectives 1998 106 supplement 1 191 201 (Pubitemid 28196044)
22. Boyes W. K., Essentiality, toxicity, and uncertainty in the risk assessment of manganese Journal of Toxicology and Environmental Health A 2010 73 2-3 159 165
23. Davis J. M., Inhalation health risks of manganese: an EPA perspective NeuroToxicology 1999 20 2-3 511 518 (Pubitemid 29268590)
24. U.S. Environmental Protection Agency (USEPA),. Fuels and fuel additives; waiver decision/circuit court remand. Fed Reg 59:42227-42247, 1994
25. U.S. Environmental Protection Agency (USEPA) (2011),. Comments on the Gasoline Additive MMT (methylcyclopentadienyl manganese tricarbonyl), 2011, http://www.epa.gov/otaq/regs/fuels/additive/mmtcmts.htm
26. Garrison A. W., Cipollone M. G., Wolfe N. L., Swank R. R., Environmental fate of methylcyclopentadienyl manganese tricarbonyl Environmental Toxicology and Chemistry 1995 14 11 1859 1864
27. Ter Haar G. L., Griffing M. E., Brandt M., Methylcyclopentadienyl manganese tricarbonyl as an antiknock: composition and fate of manganese exhaust products Journal of the Air Pollution Control Association 1975 25 8 858 860
28. Zayed J., Hong B., L'Espérance G., Characterization of manganese-containing particles collected from the exhaust emissions of automobiles running with MMT additive Environmental Science and Technology 1999 33 19 3341 3346 (Pubitemid 29461572)
29. Colmenares C., Deutsch S., Evans C., Nelson A. J., Terminello L. J., Reynolds J. G., Roos J. W., Smith I. L., Analysis of manganese particulates from automotive decomposition of methylcyclopentadienyl manganese tricarbonyl Applied Surface Science 1999 151 3 189 202 (Pubitemid 30509078)
30. Mlders N., Schilling P. J., Wong J., Rods J. W., Smith I. L., X-ray fluorescence mapping and micro-XANES spectroscopic characterization of exhaust particulates emitted from auto engines burning MMT-added gasoline Environmental Science and Technology 2001 35 15 3122 3129 (Pubitemid 32881743)
31. Ressler T., Wong J., Roos J., Smith I. L., Quantitative speciation of mn-bearing particulates emitted from autos burning (methylcyclopentadienyl) manganese tricarbonyl-added gasolines using XANES spectroscopy Environmental Science and Technology 2000 34 6 950 958 (Pubitemid 30155195)
32. Aschner M., Erikson K. M., Dorman D. C., Manganese dosimetry: species differences and implications for neurotoxicity Critical Reviews in Toxicology 2005 35 1 1 32 (Pubitemid 40179899)
33. Boyes W. K., Miller D. B., A review of rodent models of manganese neurotoxicity Neurotoxicology 1998 abstract 468
34. Olanow C. W., Good P. F., Shinotoh H., Hewitt K. A., Vingerhoets F., Snow B. J., Beal M. F., Calne D. B., Perl D. P., Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study Neurology 1996 46 2 492 498 (Pubitemid 26081339)
35. Dorman D. C., Struve M. F., Marshall M. W., Parkinson C. U., James R. A., Wong B. A., Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation Toxicological Sciences 2006 92 1 201 210 (Pubitemid 43985802)
36. Dorman D. C., Struve M. F., Wong B. A., Dye J. A., Robertson I. D., Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation Toxicological Sciences 2006 92 1 219 227 (Pubitemid 43985804)
37. Dorman D. C., Struve M. F., Gross E. A., Wong B. A., Howroyd P. C., Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys Respiratory Research 2005 6, article 121
38. Struve M. F., McManus B. E., Wong B. A., Dorman D. C., Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation American Journal of Industrial Medicine 2007 50 10 772 778 (Pubitemid 350219006)
39. Erikson K. M., Dorman D. C., Lash L. H., Aschner M., Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity Toxicological Sciences 2007 97 2 459 466 (Pubitemid 47073861)
40. Dorman D. C., Struve M. F., Norris A., Higgins A. J., Metabolomic analyses of body fluids after subchronic manganese inhalation in Rhesus monkeys Toxicological Sciences 2008 106 1 46 54
41. Vitarella D., James R. A., Miller K. L., Struve M. F., Wong B. A., Dorman D. C., Development of an inhalation system for the simultaneous exposure of rat dams and pups during developmental neurotoxicity studies Inhalation Toxicology 1998 10 12 1095 1117 (Pubitemid 29032605)
42. Dorman D. C., McElveen A. M., Marshall M. W., Parkinson C. U., James R. A., Struve M. F., Wong B. A., Maternal-fetal distribution of manganese in the rat following inhalation exposure to manganese sulfate NeuroToxicology 2005 26 4 625 632 (Pubitemid 41175897)
43. Schroeter J. D., Nong A., Yoon M., Taylor M. D., Dorman D. C., Andersen M. E., Clewell H. J. III, Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models Toxicological Sciences 2011 120 2 481 498
44. Dorman D. C., Struve M. F., James R. A., Marshall M. W., Parkinson C. U., Wong B. A., Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure Toxicology and Applied Pharmacology 2001 170 2 79 87 (Pubitemid 32108682)
45. Weiss B., Manganese in the context of an integrated risk and decision process NeuroToxicology 1999 20 2-3 519 526 (Pubitemid 29268591)
46. Vitarella D., Wong B. A., Moss O. R., Dorman D. C., Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure Toxicology and Applied Pharmacology 2000 163 3 279 285 (Pubitemid 30160036)
47. Dorman D. C., Struve M. F., Wong B. A., Brain manganese concentrations in rats following manganese tetroxide inhalation are unaffected by dietary manganese intake NeuroToxicology 2002 23 2 185 195
48. Brenneman K. A., Wong B. A., Buccellato M. A., Costa E. R., Gross E. A., Dorman D. C., Direct olfactory transport of inhaled manganese (54 MnCl 2) to the rat brain: toxicokinetic investigations in a unilateral nasal occlusion model Toxicology and Applied Pharmacology 2000 169 3 238 248 (Pubitemid 32048501)
49. Dorman D. C., Brenneman K. A., McElveen A. M., Lynch S. E., Roberts K. C., Wong B. A., Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain Journal of Toxicology and Environmental Health A 2002 65 20 1493 1511 (Pubitemid 35217497)
50. Dorman D. C., McManus B. E., Marshall M. W., James R. A., Struve M. F., Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats Toxicology and Applied Pharmacology 2004 197 2 113 124 (Pubitemid 38639902)
51. Dorman D. C., Struve M. F., Vitarella D., Byerly F. L., Goetz J., Miller R., Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure Journal of Applied Toxicology 2000 20 3 179 187 (Pubitemid 30234904)
52. Vitarella D., Moss O., Dorman D. C., Pulmonary clearance of manganese phosphate, manganese sulfate, and manganese tetraoxide by CD rats following intratracheal instillation Inhalation Toxicology 2000 12 10 941 957
53. Leavens T. L., Rao D., Andersen M. E., Dorman D. C., Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling Toxicological Sciences 2007 97 2 265 278 (Pubitemid 47073844)
54. Dorman D. C., Struve M. F., James A., McManus B. E., Marshall M. W., Wong B. A., Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats Toxicological Sciences 2001 60 2 242 251 (Pubitemid 32273312)
55. Dorman D. C., McElveen A. M., Marshall M. W., Parkinson C. U., James R. A., Struve M. F., Wong B. A., Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation exposure to inhaled manganese sulfate Toxicological Sciences 2005 84 1 12 21 (Pubitemid 40340268)
56. Yoon M., Nong A., Clewell H. J., Taylor M. D., Dorman D. C., Andersen M. E., Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model Toxicological Sciences 2009 112 1 23 43
57. Ballatori N., Miles E., Clarkson T. W., Homeostatic control of manganese excretion in the neonatal rat American Journal of PhysiologyRegulatory Integrative and Comparative Physiology 1987 252 5, part 2 R842 R847
58. National Research Council (NRC), Toxicity Testing in the 21st Century: A Vision and a Strategy 2007 Washington, DC, USA National Academy Press
59. Krewski D., Andersen M. E., Mantus E., Zeise L., Toxicity testing in the 21st century: implications for human health risk assessment Risk Analysis 2009 29 4 474 479
60. Slikker W. Jr., Andersen M. E., Bogdanffy M. S., Bus J. S., Cohen S. D., Conolly R. B., David R. M., Doerrer N. G., Dorman D. C., Gaylor D. W., Hattis D., Rogers J. M., Woodrow Setzer R., Swenberg J. A., Wallace K., Dose-dependent transitions in mechanisms of toxicity Toxicology and Applied Pharmacology 2004 201 3 203 225 (Pubitemid 39593625)
61. Slikker W. Jr., Andersen M. E., Bogdanffy M. S., Bus J. S., Cohen S. D., Conolly R. B., David R. M., Doerrer N. G., Dorman D. C., Gaylor D. W., Hattis D., Rogers J. M., Setzer R. W., Swenberg J. A., Wallace K., Dose-dependent transitions in mechanisms of toxicity: case studies Toxicology and Applied Pharmacology 2004 201 3 226 294 (Pubitemid 39593626)