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Volumn 23, Issue 8, 2012, Pages 1435-1445

Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: New perspective for Rett syndrome

Author keywords

[No Author keywords available]

Indexed keywords

METHYL CPG BINDING PROTEIN 2; RETINOIC ACID;

EID: 84859732309     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-09-0784     Document Type: Article
Times cited : (38)

References (41)
  • 1
    • 3442895308 scopus 로고    scopus 로고
    • Real-time quantitative PCR as a routine method for screening large rearrangements in Rett syndrome: Report of one case of MECP2 deletion and one case of MECP2 duplication
    • DOI 10.1002/humu.20065
    • Ariani F, Mari F, Pescucci C, Longo I, Bruttini M, Meloni I, Hayek G, Rocchi R, Zappella M, Renieri A (2004). Real-time quantitative PCR as a routine method for screening large rearrangements in Rett syndrome: report of one case of MECP2 deletion and one case of MECP2 duplication. Hum Mutat 24, 172-177. (Pubitemid 39006597)
    • (2004) Human Mutation , vol.24 , Issue.2 , pp. 172-177
    • Ariani, F.1    Mari, F.2    Pescucci, C.3    Longo, I.4    Bruttini, M.5    Meloni, I.6    Hayek, G.7    Rocchi, R.8    Zappella, M.9    Renieri, A.10
  • 2
    • 33646893456 scopus 로고    scopus 로고
    • Molecular genetics of Rett syndrome: When DNA methylation goes unrecognized
    • DOI 10.1038/nrg1878, PII N1878
    • Bienvenu T, Chelly J (2006). Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. Nat Rev Genet 7, 415-426. (Pubitemid 43780485)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.6 , pp. 415-426
    • Bienvenu, T.1    Chelly, J.2
  • 3
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J, d'Adda di Fagagna F (2007). Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8, 729-740.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 4
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    • DOI 10.1038/85906
    • Chen RZ, Akbarian S, Tudor M, Jaenisch R (2001). Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27, 327-331. (Pubitemid 32201857)
    • (2001) Nature Genetics , vol.27 , Issue.3 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2    Tudor, M.3    Jaenisch, R.4
  • 5
    • 0024492340 scopus 로고
    • Phenotypic diversification in human neuroblastoma cells: Expression of distinct neural crest lineages
    • Ciccarone V, Spengler BA, Meyers MB, Biedler JL, Ross RA (1989). Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res 49, 219-225. (Pubitemid 19024435)
    • (1989) Cancer Research , vol.49 , Issue.1 , pp. 219-225
    • Ciccarone, V.1    Spengler, B.A.2    Meyers, M.B.3    Biedler, J.L.4    Ross, R.A.5
  • 7
    • 0037423186 scopus 로고    scopus 로고
    • The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
    • DOI 10.1074/jbc.M210256200
    • Fuks F, Hurd PJ, Wolf D, Nan X, Bird AP, Kouzarides T (2003). The methyl- CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 278, 4035-4040. (Pubitemid 36801137)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.6 , pp. 4035-4040
    • Fuks, F.1    Hurd, P.J.2    Wolf, D.3    Nan, X.4    Bird, A.P.5    Kouzarides, T.6
  • 9
    • 34548148201 scopus 로고    scopus 로고
    • Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals?
    • DOI 10.1038/nrm2240, PII NRM2240
    • Giorgio M, Trinei M, Migliaccio E, Pelicci PG (2007). Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol 8, 722-728. (Pubitemid 47312827)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 722-728
    • Giorgio, M.1    Trinei, M.2    Migliaccio, E.3    Pelicci, P.G.4
  • 10
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic rett syndrome
    • DOI 10.1038/85899
    • Guy J, Hendrich B, Holmes M, Martin JE, Bird A (2001). A mouse Mecp2- null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27, 322-326. (Pubitemid 32201856)
    • (2001) Nature Genetics , vol.27 , Issue.3 , pp. 322-326
    • Guy, J.1    Hendrich, B.2    Holmes, M.3    Martin, J.E.4    Bird, A.5
  • 11
    • 0035694237 scopus 로고    scopus 로고
    • Identification of essential genes in cultured mammalian cells using small interfering RNAs
    • Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K (2001). Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 114, 4557-4565. (Pubitemid 34086890)
    • (2001) Journal of Cell Science , vol.114 , Issue.24 , pp. 4557-4565
    • Harborth, J.1    Elbashir, S.M.2    Bechert, K.3    Tuschl, T.4    Weber, K.5
  • 13
    • 70349693968 scopus 로고    scopus 로고
    • Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence
    • Helmbold H, Komm N, Deppert W, Bohn W (2009). Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence. Oncogene 28, 3456-3467.
    • (2009) Oncogene , vol.28 , pp. 3456-3467
    • Helmbold, H.1    Komm, N.2    Deppert, W.3    Bohn, W.4
  • 15
    • 0035893582 scopus 로고    scopus 로고
    • RB2/p130 ectopic gene expression in neuroblastoma stem cells: Evidence of cell-fate restriction and induction of differentiation
    • DOI 10.1042/0264-6021:3600569
    • Jori FP, Galderisi U, Piegari E, Peluso G, Cipollaro M, Cascino A, Giordano A, Melone MA (2001). RB2/p130 ectopic gene expression in neuroblastoma stem cells: evidence of cell-fate restriction and induction of differentiation. Biochem J 360, 569-577. (Pubitemid 34020262)
    • (2001) Biochemical Journal , vol.360 , Issue.3 , pp. 569-577
    • Jori, F.P.1    Galderisi, U.2    Piegari, E.3    Peluso, G.4    Cipollaro, M.5    Cascino, A.6    Giordano, A.7    Melone, M.A.B.8
  • 16
    • 11844286278 scopus 로고    scopus 로고
    • RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells
    • DOI 10.1038/sj.cdd.4401499
    • Jori FP, Melone MA, Napolitano MA, Cipollaro M, Cascino A, Giordano A, Galderisi U (2005a). RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. Cell Death Differ 12, 65-77. (Pubitemid 40090029)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.1 , pp. 65-77
    • Jori, F.P.1    Melone, M.A.B.2    Napolitano, M.A.3    Cipollaro, M.4    Cascino, A.5    Giordano, A.6    Galderisi, U.7
  • 19
    • 0037381336 scopus 로고    scopus 로고
    • The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells
    • DOI 10.1002/neu.10201
    • Jung BP, Jugloff DG, Zhang G, Logan R, Brown S, Eubanks JH (2003). The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells. J Neurobiol 55, 86-96. (Pubitemid 36396964)
    • (2003) Journal of Neurobiology , vol.55 , Issue.1 , pp. 86-96
    • Jung, B.P.1    Jugloff, D.G.M.2    Zhang, G.3    Logan, R.4    Brown, S.5    Eubanks, J.H.6
  • 21
    • 80052155858 scopus 로고    scopus 로고
    • Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome
    • Kim KY, Hysolli E, Park IY (2011). Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc Natl Acad Sci USA 108, 14169-14174.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14169-14174
    • Kim, K.Y.1    Hysolli, E.2    Park, I.Y.3
  • 22
    • 0038136913 scopus 로고    scopus 로고
    • Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
    • DOI 10.1074/jbc.M209923200
    • Kimura H, Shiota K (2003). Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase Dnmt1. J Biol Chem 278, 4806-4812. (Pubitemid 36800984)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.7 , pp. 4806-4812
    • Kimura, H.1    Shiota, K.2
  • 23
    • 7244243971 scopus 로고    scopus 로고
    • MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions
    • DOI 10.1016/j.mcn.2004.07.006, PII S1044743104001708
    • Kishi N, Macklis JD (2004). MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol Cell Neurosci 27, 306-321. (Pubitemid 39433843)
    • (2004) Molecular and Cellular Neuroscience , vol.27 , Issue.3 , pp. 306-321
    • Kishi, N.1    Macklis, J.D.2
  • 24
    • 77649339642 scopus 로고    scopus 로고
    • MeCP2 functions largely cell-autonomously, but also non-cell- autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons
    • Kishi N, Macklis JD (2010). MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons. Exp Neurol 222, 51-58.
    • (2010) Exp Neurol , vol.222 , pp. 51-58
    • Kishi, N.1    Macklis, J.D.2
  • 26
    • 1642441427 scopus 로고    scopus 로고
    • Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain
    • DOI 10.1016/j.neuroscience.2003.11.025
    • Mullaney BC, Johnston MV, Blue ME (2004). Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain. Neuroscience 123, 939-949. (Pubitemid 38130104)
    • (2004) Neuroscience , vol.123 , Issue.4 , pp. 939-949
    • Mullaney, B.C.1    Johnston, M.V.2    Blue, M.E.3
  • 32
  • 33
    • 84859701436 scopus 로고    scopus 로고
    • Silencing of methyl CpG binding protein 2 (MECP2) in mesenchymal stem cells induces senescence along with decreased expression of stemness-related genes. Presented at the Poster Section, Abstract 80
    • Squillaro T, Alessio N, Cipollaro M, Renieri A, Galderisi U (2008a). Silencing of methyl CpG binding protein 2 (MECP2) in mesenchymal stem cells induces senescence along with decreased expression of stemness-related genes. Presented at the 6th ISSCR Annual Meeting 2008, Philadelphia, PA, Poster Section, Abstract 80.
    • (2008) 6th ISSCR Annual Meeting 2008, Philadelphia, PA
    • Squillaro, T.1    Alessio, N.2    Cipollaro, M.3    Renieri, A.4    Galderisi, U.5
  • 34
    • 77952317326 scopus 로고    scopus 로고
    • Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA
    • Squillaro T, Alessio N, Cipollaro M, Renieri A, Giordano A, Galderisi U (2010). Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA. FASEB J 24, 1593-1603.
    • (2010) FASEB J , vol.24 , pp. 1593-1603
    • Squillaro, T.1    Alessio, N.2    Cipollaro, M.3    Renieri, A.4    Giordano, A.5    Galderisi, U.6
  • 36
    • 41849149683 scopus 로고    scopus 로고
    • A case report: Bone marrow mesenchymal stem cells from a rett syndrome patient are prone to senescence and show a lower degree of apoptosis
    • DOI 10.1002/jcb.21582
    • Squillaro T, Hayek G, Farina E, Cipollaro M, Renieri A, Galderisi U (2008c). A case report: bone marrow mesenchymal stem cells from a Rett syndrome patient are prone to senescence and show a lower degree of apoptosis. J Cell Biochem 103, 1877-1885. (Pubitemid 351501918)
    • (2008) Journal of Cellular Biochemistry , vol.103 , Issue.6 , pp. 1877-1885
    • Squillaro, T.1    Hayek, G.2    Farina, E.3    Cipollaro, M.4    Renieri, A.5    Galderisi, U.6
  • 37
    • 0043178993 scopus 로고    scopus 로고
    • A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by Notch in Xenopus embryos
    • DOI 10.1016/S1097-2765(03)00276-4
    • Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR (2003). A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos. Mol Cell 12, 425-435. (Pubitemid 37238929)
    • (2003) Molecular Cell , vol.12 , Issue.2 , pp. 425-435
    • Stancheva, I.1    Collins, A.L.2    Van Den, V.I.B.3    Zoghbi, H.4    Meehan, R.R.5
  • 40
    • 0034663515 scopus 로고    scopus 로고
    • Adult rat and human bone marrow stromal cells differentiate into neurons
    • DOI 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C
    • Woodbury D, Schwarz EJ, Prockop DJ, Black IB (2000). Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61, 364-370. (Pubitemid 30620221)
    • (2000) Journal of Neuroscience Research , vol.61 , Issue.4 , pp. 364-370
    • Woodbury, D.1    Schwarz, E.J.2    Prockop, D.J.3    Black, I.B.4


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