-
1
-
-
33845500278
-
Syk-dependent mTOR activation in follicular lymphoma cells
-
DOI 10.1182/blood-2006-05-026203
-
Leseux L, Hamdi SM, Al Saati T, Capilla F, Recher C, Laurent G et al. Syk-dependent mTOR activation in follicular lymphoma cells. Blood 2006; 108: 4156-4162. (Pubitemid 44913287)
-
(2006)
Blood
, vol.108
, Issue.13
, pp. 4156-4162
-
-
Leseux, L.1
Hamdi, S.M.2
Al, S.T.3
Capilla, F.4
Recher, C.5
Laurent, G.6
Bezombes, C.7
-
2
-
-
38049151149
-
PKC zeta mTOR pathway: A new target for rituximab therapy in follicular lymphoma
-
Leseux L, Laurent G, Laurent C, Rigo M, Blanc A, Olive D et al. PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. Blood 2008; 111: 285-291.
-
(2008)
Blood
, vol.111
, pp. 285-291
-
-
Leseux, L.1
Laurent, G.2
Laurent, C.3
Rigo, M.4
Blanc, A.5
Olive, D.6
-
3
-
-
78649481961
-
Membrane-associated signaling in human B-lymphoma lines
-
Tauzin S, Ding H, Burdevet D, Borisch B, Hoessli DC. Membrane-associated signaling in human B-lymphoma lines. Exp Cell Res 2011; 317: 151-162.
-
(2011)
Exp Cell Res
, vol.317
, pp. 151-162
-
-
Tauzin, S.1
Ding, H.2
Burdevet, D.3
Borisch, B.4
Hoessli, D.C.5
-
4
-
-
77954315861
-
Spleen tyrosine kinases: Biology, therapeutic targets and drugs
-
Riccaboni M, Bianchi I, Petrillo P. Spleen tyrosine kinases: biology, therapeutic targets and drugs. Drug Discov Today 2010; 15: 517-530.
-
(2010)
Drug Discov Today
, vol.15
, pp. 517-530
-
-
Riccaboni, M.1
Bianchi, I.2
Petrillo, P.3
-
5
-
-
77952887713
-
The SYK tyrosine kinase: A crucial player in diverse biological functions
-
Mocsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 2010; 10: 387-402.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 387-402
-
-
Mocsai, A.1
Ruland, J.2
Tybulewicz, V.L.3
-
6
-
-
67649425382
-
Syk and pTyr'd: Signaling through the B cell antigen receptor
-
Geahlen RL. Syk and pTyr'd: signaling through the B cell antigen receptor. Biochim Biophys Acta 2009; 1793: 1115-1127.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 1115-1127
-
-
Geahlen, R.L.1
-
7
-
-
33845268014
-
2 integrin (CD11/CD18)-mediated neutrophil migration
-
DOI 10.1182/blood-2005-12-030387
-
Schymeinsky J, Sindrilaru A, Frommhold D, Sperandio M, Gerstl R, Then C et al. The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration. Blood 2006; 108: 3919-3927. (Pubitemid 44864578)
-
(2006)
Blood
, vol.108
, Issue.12
, pp. 3919-3927
-
-
Schymeinsky, J.1
Sindrilaru, A.2
Frommhold, D.3
Sperandio, M.4
Gerstl, R.5
Then, C.6
Mocsai, A.7
Scharffetter-Kochanek, K.8
Walzog, B.9
-
8
-
-
0034810421
-
A critical role for Syk in endothelial cell proliferation and migration
-
DOI 10.1006/bbrc.2001.5355
-
Inatome R, Yanagi S, Takano T, Yamamura H. A critical role for Syk in endothelial cell proliferation and migration. Biochem Biophys Res Commun 2001; 286: 195-199. (Pubitemid 32917669)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.286
, Issue.1
, pp. 195-199
-
-
Inatome, R.1
Yanagi, S.2
Takano, T.3
Yamamura, H.4
-
9
-
-
79551634518
-
SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70
-
Pearce G, Audzevich T, Jessberger R. SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70. Blood 2011; 117: 1574-1584.
-
(2011)
Blood
, vol.117
, pp. 1574-1584
-
-
Pearce, G.1
Audzevich, T.2
Jessberger, R.3
-
10
-
-
0034680108
-
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells
-
Coopman PJ, Do MT, Barth M, Bowden ET, Hayes AJ, Basyuk E et al. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000; 406: 742-747.
-
(2000)
Nature
, vol.406
, pp. 742-747
-
-
Coopman, P.J.1
Do, M.T.2
Barth, M.3
Bowden, E.T.4
Hayes, A.J.5
Basyuk, E.6
-
11
-
-
20544451947
-
The non-receptor-associated tyrosine kinase syk is a regulator of metastatic behavior in human melanoma cells
-
DOI 10.1111/j.0022-202X.2005.23685.x
-
Hoeller C, Thallinger C, Pratscher B, Bister MD, Schicher N, Loewe R et al. The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells. J Invest Dermatol 2005; 124: 1293-1299. (Pubitemid 40847418)
-
(2005)
Journal of Investigative Dermatology
, vol.124
, Issue.6
, pp. 1293-1299
-
-
Hoeller, C.1
Thallinger, C.2
Pratscher, B.3
Bister, M.D.4
Schicher, N.5
Loewe, R.6
Heere-Ress, E.7
Roka, F.8
Sexl, V.9
Pehamberger, H.10
-
12
-
-
3142711022
-
Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma
-
Wang S, Ding YB, Chen GY, Xia JG, Wu ZY. Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. World J Gastroenterol 2004; 10: 1815-1818. (Pubitemid 38931212)
-
(2004)
World Journal of Gastroenterology
, vol.10
, Issue.12
, pp. 1815-1818
-
-
Wang, S.1
Ding, Y.-B.2
Chen, G.-Y.3
Xia, J.-G.4
Wu, Z.-Y.5
-
13
-
-
0037458567
-
Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 30-kinase activity in breast cancer cells
-
DOI 10.1074/jbc.M208905200
-
Mahabeleshwar GH, Kundu GC. Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 30-kinase activity in breast cancer cells. J Biol Chem 2003; 278: 6209-6221. (Pubitemid 36800876)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.8
, pp. 6209-6221
-
-
Mahabeleshwar, G.H.1
Kundu, G.C.2
-
14
-
-
33646847002
-
Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells
-
DOI 10.1074/jbc.M507305200
-
Lu J, Lin WH, Chen SY, Longnecker R, Tsai SC, Chen CL et al. Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells. J Biol Chem 2006; 281: 8806-8814. (Pubitemid 43847987)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.13
, pp. 8806-8814
-
-
Lu, J.1
Lin, W.-H.2
Chen, S.-Y.3
Longnecker, R.4
Tsai, S.-C.5
Chen, C.-L.6
Tsai, C.-H.7
-
15
-
-
34548019442
-
Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck
-
DOI 10.1158/0008-5472.CAN-07-0331
-
Luangdilok S, Box C, Patterson L, Court W, Harrington K, Pitkin L et al. Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck. Cancer Res 2007; 67: 7907-7916. (Pubitemid 47281387)
-
(2007)
Cancer Research
, vol.67
, Issue.16
, pp. 7907-7916
-
-
Luangdilok, S.1
Box, C.2
Patterson, L.3
Court, W.4
Harrington, K.5
Pitkin, L.6
Rhys-Evans, P.7
O-charoenrat, P.8
Eccles, S.9
-
16
-
-
76949101422
-
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site
-
Letellier E, Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S et al. CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity 2010; 32: 240-252.
-
(2010)
Immunity
, vol.32
, pp. 240-252
-
-
Letellier, E.1
Kumar, S.2
Sancho-Martinez, I.3
Krauth, S.4
Funke-Kaiser, A.5
Laudenklos, S.6
-
17
-
-
33744948425
-
Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis
-
DOI 10.1074/jbc.M512546200
-
Chakraborty G, Rangaswami H, Jain S, Kundu GC. Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis. J Biol Chem 2006; 281: 11322-11331. (Pubitemid 43855557)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.16
, pp. 11322-11331
-
-
Chakraborty, G.1
Rangaswami, H.2
Jain, S.3
Kundu, G.C.4
-
18
-
-
33646576169
-
Matrix metalloproteinases and tumor metastasis
-
DOI 10.1007/s10555-006-7886-9, Metalloproteinases and Cancer
-
Deryugina EI, Quigley JP. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 2006; 25: 9-34. (Pubitemid 43723979)
-
(2006)
Cancer and Metastasis Reviews
, vol.25
, Issue.1
, pp. 9-34
-
-
Deryugina, E.I.1
Quigley, J.P.2
-
19
-
-
15244342010
-
Matrix metalloproteinases as therapeutic targets in cancer
-
DOI 10.2174/1568009053765799
-
Vihinen P, Ala-aho R, Kahari VM. Matrix metalloproteinases as therapeutic targets in cancer. Curr Cancer Drug Targets 2005; 5: 203-220. (Pubitemid 40694861)
-
(2005)
Current Cancer Drug Targets
, vol.5
, Issue.3
, pp. 203-220
-
-
Vihinen, P.1
Ala-Aho, R.2
Kahari, V.-M.3
-
20
-
-
77950931419
-
Matrix metalloproteinases: Regulators of the tumor microenvironment
-
Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010; 141: 52-67.
-
(2010)
Cell
, vol.141
, pp. 52-67
-
-
Kessenbrock, K.1
Plaks, V.2
Werb, Z.3
-
21
-
-
0037699954
-
The biology of VEGF and its receptors
-
DOI 10.1038/nm0603-669
-
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676. (Pubitemid 36749215)
-
(2003)
Nature Medicine
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.-P.2
LeCouter, J.3
-
22
-
-
61649123322
-
Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma
-
Ruan J, Hajjar K, Rafii S, Leonard JP. Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma. Ann Oncol 2009; 20: 413-424.
-
(2009)
Ann Oncol
, vol.20
, pp. 413-424
-
-
Ruan, J.1
Hajjar, K.2
Rafii, S.3
Leonard, J.P.4
-
23
-
-
7244236494
-
Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
-
DOI 10.1182/blood-2004-01-0226
-
Wang ES, Teruya-Feldstein J, Wu Y, Zhu Z, Hicklin DJ, Moore MA. Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo. Blood 2004; 104: 2893-2902. (Pubitemid 39434977)
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2893-2902
-
-
Wang, E.S.1
Teruya-Feldstein, J.2
Wu, Y.3
Zhu, Z.4
Hicklin, D.J.5
Moore, M.A.S.6
-
24
-
-
0141778596
-
Expression levels of vascular endothelial growth factor, matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 and 2 in the plasma of patients with ovarian carcinoma
-
DOI 10.1016/S0959-8049(03)00427-1
-
Manenti L, Paganoni P, Floriani I, Landoni F, Torri V, Buda A et al. Expression levels of vascular endothelial growth factor, matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 and 2 in the plasma of patients with ovarian carcinoma. Eur J Cancer 2003; 39: 1948-1956. (Pubitemid 37311193)
-
(2003)
European Journal of Cancer
, vol.39
, Issue.13
, pp. 1948-1956
-
-
Manenti, L.1
Paganoni, P.2
Floriani, I.3
Landoni, F.4
Torri, V.5
Buda, A.6
Taraboletti, G.7
Labianca, R.8
Belotti, D.9
Giavazzi, R.10
-
25
-
-
0029738062
-
Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer
-
Ohta Y, Endo Y, Tanaka M, Shimizu J, Oda M, Hayashi Y et al. Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer. Clin Cancer Res 1996; 2: 1411-1416. (Pubitemid 26299442)
-
(1996)
Clinical Cancer Research
, vol.2
, Issue.8
, pp. 1411-1416
-
-
Ohta, Y.1
Endo, Y.2
Tanaka, M.3
Shimizu, J.4
Oda, M.5
Hayashi, Y.6
Watanabe, Y.7
Sasaki, T.8
-
26
-
-
1842486567
-
Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in Hodgkin's and non-Hodgkin's lymphoma
-
DOI 10.1111/j.1368-5031.2004.0023.x
-
Hazar B, Polat G, Seyrek E, Bagdatoglglu O, Kanik A, Tiftik N. Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in Hodgkin's and non-Hodgkin's lymphoma. Int J Clin Pract 2004; 58: 139-143. (Pubitemid 38425743)
-
(2004)
International Journal of Clinical Practice
, vol.58
, Issue.2
, pp. 139-143
-
-
Hazar, B.1
Polat, G.2
Seyrek, E.3
Bagdatoglglu, O.4
Kanik, A.5
Tiftik, N.6
-
27
-
-
0034485309
-
Matrix metalloproteinases and their tissue inhibitors - Expression, role and regulation in human malignant non-Hodgkin's lymphomas
-
Kossakowska AE, Urbanski SJ, Janowska-Wieczorek A. Matrix metalloproteinases and their tissue inhibitors - expression, role and regulation in human malignant non-Hodgkin's lymphomas. Leuk Lymphoma 2000; 39: 485-493. (Pubitemid 32162388)
-
(2000)
Leukemia and Lymphoma
, vol.39
, Issue.5-6
, pp. 485-493
-
-
Kossakowska, A.E.1
Urbanski, S.J.2
Janowska-Wieczorek, A.3
-
28
-
-
0034548821
-
Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: A single-institution study of 200 patients
-
Salven P, Orpana A, Teerenhovi L, Joensuu H. Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients. Blood 2000; 96: 3712-3718.
-
(2000)
Blood
, vol.96
, pp. 3712-3718
-
-
Salven, P.1
Orpana, A.2
Teerenhovi, L.3
Joensuu, H.4
-
29
-
-
0032705203
-
SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling
-
Beitz LO, Fruman DA, Kurosaki T, Cantley LC, Scharenberg AM. SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J Biol Chem 1999; 274: 32662-32666. (Pubitemid 129535293)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.46
, pp. 32662-32666
-
-
Beitz, L.O.1
Fruman, D.A.2
Kurosaki, T.3
Cantley, L.C.4
Scharenberg, A.M.5
-
30
-
-
52449106253
-
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin- 1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
-
Folkes AJ, Ahmadi K, Alderton WK, Alix S, Baker SJ, Box G et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)- 4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem 2008; 51: 5522-5532.
-
(2008)
J Med Chem
, vol.51
, pp. 5522-5532
-
-
Folkes, A.J.1
Ahmadi, K.2
Alderton, W.K.3
Alix, S.4
Baker, S.J.5
Box, G.6
-
31
-
-
77955986074
-
Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941
-
Salphati L, Wong H, Belvin M, Bradford D, Edgar KA, Prior WW et al. Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941. Drug Metab Dispos 2010; 38: 1436-1442.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 1436-1442
-
-
Salphati, L.1
Wong, H.2
Belvin, M.3
Bradford, D.4
Edgar, K.A.5
Prior, W.W.6
-
32
-
-
51749123158
-
Prognostic significance of p53 and matrix metalloproteinase-9 expression in follicular lymphoma
-
Pennanen H, Kuittinen O, Soini Y, Turpeenniemi-Hujanen T. Prognostic significance of p53 and matrix metalloproteinase-9 expression in follicular lymphoma. Eur J Haematol 2008; 81: 289-297.
-
(2008)
Eur J Haematol
, vol.81
, pp. 289-297
-
-
Pennanen, H.1
Kuittinen, O.2
Soini, Y.3
Turpeenniemi-Hujanen, T.4
-
33
-
-
68449103587
-
Alterations in regulators of the extracellular matrix in non-Hodgkin lymphomas
-
Negaard HF, Svennevig K, Kolset SO, Iversen N, Lothe IM, Ostenstad B et al. Alterations in regulators of the extracellular matrix in non-Hodgkin lymphomas. Leuk Lymphoma 2009; 50: 998-1004.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 998-1004
-
-
Negaard, H.F.1
Svennevig, K.2
Kolset, S.O.3
Iversen, N.4
Lothe, I.M.5
Ostenstad, B.6
-
34
-
-
34247897170
-
Microvessel density and expression of vascular endothelial growth factor and its receptors in diffuse large B-cell lymphoma subtypes
-
DOI 10.2353/ajpath.2007.060901
-
Gratzinger D, Zhao S, Marinelli RJ, Kapp AV, Tibshirani RJ, Hammer AS et al. Microvessel density and expression of vascular endothelial growth factor and its receptors in diffuse large B-cell lymphoma subtypes. Am J Pathol 2007; 170: 1362-1369. (Pubitemid 47339342)
-
(2007)
American Journal of Pathology
, vol.170
, Issue.4
, pp. 1362-1369
-
-
Gratzinger, D.1
Zhao, S.2
Marinelli, R.J.3
Kapp, A.V.4
Tibshirani, R.J.5
Hammer, A.S.6
Hamilton-Dutoit, S.7
Natkunam, Y.8
-
35
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
DOI 10.1038/nm0202-128
-
Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-135. (Pubitemid 34155123)
-
(2002)
Nature Medicine
, vol.8
, Issue.2
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
Jauch, K.-W.11
Geissler, E.K.12
-
36
-
-
63849309885
-
Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target
-
Young RM, Hardy IR, Clarke RL, Lundy N, Pine P, Turner BC et al. Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target. Blood 2009; 113: 2508-2516.
-
(2009)
Blood
, vol.113
, pp. 2508-2516
-
-
Young, R.M.1
Hardy, I.R.2
Clarke, R.L.3
Lundy, N.4
Pine, P.5
Turner, B.C.6
-
37
-
-
33751197936
-
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
-
Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther 2006; 319: 998-1008.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 998-1008
-
-
Braselmann, S.1
Taylor, V.2
Zhao, H.3
Wang, S.4
Sylvain, C.5
Baluom, M.6
-
38
-
-
9144242962
-
Expression of Matrix Metalloproteinase 9 Is a Prognostic Factor in Patients with Non-Hodgkin Lymphoma
-
DOI 10.1002/cncr.11905
-
Sakata K, Satoh M, Someya M, Asanuma H, Nagakura H, Oouchi A et al. Expression of matrix metalloproteinase 9 is a prognostic factor in patients with non-Hodgkin lymphoma. Cancer 2004; 100: 356-365. (Pubitemid 38063646)
-
(2004)
Cancer
, vol.100
, Issue.2
, pp. 356-365
-
-
Sakata, K.-I.1
Satoh, M.2
Someya, M.3
Asanuma, H.4
Nagakura, H.5
Oouchi, A.6
Nakata, K.7
Kogawa, K.8
Koito, K.9
Hareyama, M.10
Himi, T.11
-
39
-
-
70349237504
-
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
-
Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, Wierda WG et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 2009; 114: 1029-1037.
-
(2009)
Blood
, vol.114
, pp. 1029-1037
-
-
Quiroga, M.P.1
Balakrishnan, K.2
Kurtova, A.V.3
Sivina, M.4
Keating, M.J.5
Wierda, W.G.6
-
40
-
-
59149105815
-
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
-
Chen JS, Wang Q, Fu XH, Huang XH, Chen XL, Cao LQ et al. Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9. Hepatol Res 2009; 39: 177-186.
-
(2009)
Hepatol Res
, vol.39
, pp. 177-186
-
-
Chen, J.S.1
Wang, Q.2
Fu, X.H.3
Huang, X.H.4
Chen, X.L.5
Cao, L.Q.6
-
41
-
-
33749552370
-
Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells
-
DOI 10.1074/jbc.M604013200
-
Han S, Ritzenthaler JD, Sitaraman SV, Roman J. Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells. J Biol Chem 2006; 281: 29614-29624. (Pubitemid 44536969)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.40
, pp. 29614-29624
-
-
Han, S.1
Ritzenthaler, J.D.2
Sitaraman, S.V.3
Roman, J.4
-
42
-
-
0037217977
-
Regulation of Akt-dependent cell survival by Syk and Rac
-
DOI 10.1182/blood-2002-04-1251
-
Jiang K, Zhong B, Ritchey C, Gilvary DL, Hong-Geller E, Wei S et al. Regulation of Akt-dependent cell survival by Syk and Rac. Blood 2003; 101: 236-244. (Pubitemid 36025913)
-
(2003)
Blood
, vol.101
, Issue.1
, pp. 236-244
-
-
Jiang, K.1
Zhong, B.2
Ritchey, C.3
Gilvary, D.L.4
Hong-Geller, E.5
Wei, S.6
Djeu, J.Y.7
-
43
-
-
36148962868
-
Role of mTOR in solid tumor systems: A therapeutical target against primary tumor growth, metastases, and angiogenesis
-
DOI 10.1007/s10555-007-9077-8, Forty Years of Metastasis Research: A Tribute to Dr. Isaiah J. Fidler
-
Seeliger H, Guba M, Kleespies A, Jauch KW, Bruns CJ. Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev 2007; 26: 611-621. (Pubitemid 350115107)
-
(2007)
Cancer and Metastasis Reviews
, vol.26
, Issue.3-4
, pp. 611-621
-
-
Seeliger, H.1
Guba, M.2
Kleespies, A.3
Jauch, K.-W.4
Bruns, C.J.5
-
44
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Reviews 2002; 2: 489-501. (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
45
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev 2004; 4: 335-348. (Pubitemid 38579480)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
47
-
-
79751526328
-
A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma
-
Witzig TE, Reeder CB, LaPlant BR, Gupta M, Johnston PB, Micallef IN et al. A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma. Leukemia 2010; 25: 341-347.
-
(2010)
Leukemia
, vol.25
, pp. 341-347
-
-
Witzig, T.E.1
Reeder, C.B.2
LaPlant, B.R.3
Gupta, M.4
Johnston, P.B.5
Micallef, I.N.6
-
48
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev 2009; 9: 550-562.
-
(2009)
Nat Rev
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
49
-
-
77958000904
-
The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma
-
Bhende PM, Park SI, Lim MS, Dittmer DP, Damania B. The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma. Leukemia 2010; 24: 1781-1784.
-
(2010)
Leukemia
, vol.24
, pp. 1781-1784
-
-
Bhende, P.M.1
Park, S.I.2
Lim, M.S.3
Dittmer, D.P.4
Damania, B.5
-
50
-
-
78149239933
-
Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium
-
Smith SM, van Besien K, Karrison T, Dancey J, McLaughlin P, Younes A et al. Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium. J Clin Oncol 2010; 28: 4740-4746.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4740-4746
-
-
Smith, S.M.1
Van Besien, K.2
Karrison, T.3
Dancey, J.4
McLaughlin, P.5
Younes, A.6
-
51
-
-
79953216329
-
Effect of PI3K- And mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice
-
Garcia-Martinez JM, Wullschleger S, Preston G, Guichard S, Fleming S, Alessi DR et al. Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice. Br J Cancer 2011; 104: 1116-1125.
-
(2011)
Br J Cancer
, vol.104
, pp. 1116-1125
-
-
Garcia-Martinez, J.M.1
Wullschleger, S.2
Preston, G.3
Guichard, S.4
Fleming, S.5
Alessi, D.R.6
-
52
-
-
77951184829
-
Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions
-
Schaller MD. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci 2010; 123: 1007-1013.
-
(2010)
J Cell Sci
, vol.123
, pp. 1007-1013
-
-
Schaller, M.D.1
-
53
-
-
70350353059
-
Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin
-
Coffey GP, Rajapaksa R, Liu R, Sharpe O, Kuo CC, Krauss SW et al. Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. J Cell Sci 2009; 122: 3137-3144.
-
(2009)
J Cell Sci
, vol.122
, pp. 3137-3144
-
-
Coffey, G.P.1
Rajapaksa, R.2
Liu, R.3
Sharpe, O.4
Kuo, C.C.5
Krauss, S.W.6
-
54
-
-
54749094398
-
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer
-
Iiizumi M, Bandyopadhyay S, Pai SK, Watabe M, Hirota S, Hosobe S et al. RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res 2008; 68: 7613-7620.
-
(2008)
Cancer Res
, vol.68
, pp. 7613-7620
-
-
Iiizumi, M.1
Bandyopadhyay, S.2
Pai, S.K.3
Watabe, M.4
Hirota, S.5
Hosobe, S.6
-
55
-
-
16844366544
-
Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
-
DOI 10.1158/0008-5472.CAN-04-3135
-
Wan X, Mendoza A, Khanna C, Helman LJ. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 2005; 65: 2406-2411. (Pubitemid 40490152)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2406-2411
-
-
Wan, X.1
Mendoza, A.2
Khanna, C.3
Helman, L.J.4
-
56
-
-
12544249891
-
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase
-
Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML et al. Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem 2005; 280: 1543-1551.
-
(2005)
J Biol Chem
, vol.280
, pp. 1543-1551
-
-
Moon, K.D.1
Post, C.B.2
Durden, D.L.3
Zhou, Q.4
De, P.5
Harrison, M.L.6
-
57
-
-
8544273759
-
Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
-
DOI 10.1074/jbc.M404097200
-
Skinner HD, Zheng JZ, Fang J, Agani F, Jiang BH. Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling. J Biol Chem 2004; 279: 45643-45651. (Pubitemid 39491552)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.44
, pp. 45643-45651
-
-
Skinner, H.D.1
Zheng, J.Z.2
Fang, J.3
Agani, F.4
Jiang, B.-H.5
-
58
-
-
24044529450
-
4 receptors and SP-1 transcription factor binding sites
-
DOI 10.1074/jbc.M414530200
-
Bradbury D, Clarke D, Seedhouse C, Corbett L, Stocks J, Knox A. Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites. J Biol Chem 2005; 280: 29993-30000. (Pubitemid 41216174)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.34
, pp. 29993-30000
-
-
Bradbury, D.1
Clarke, D.2
Seedhouse, C.3
Corbettt, L.4
Stocks, J.5
Knox, A.6
-
59
-
-
28544449211
-
Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression
-
DOI 10.1158/0008-5472.CAN-05-2231
-
Wang L, Devarajan E, He J, Reddy SP, Dai JL. Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression. Cancer Res 2005; 65: 10289-10297. (Pubitemid 41743721)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10289-10297
-
-
Lei, W.1
Devarajan, E.2
Jin, H.3
Reddy, S.P.4
Le, D.J.5
-
60
-
-
77955496933
-
MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells
-
Chetty C, Lakka SS, Bhoopathi P, Rao JS. MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int J Cancer 2010; 127: 1081-1095.
-
(2010)
Int J Cancer
, vol.127
, pp. 1081-1095
-
-
Chetty, C.1
Lakka, S.S.2
Bhoopathi, P.3
Rao, J.S.4
-
61
-
-
42049094423
-
Vascular endothelial growth factor stimulates organ-specific host matrix metalloproteinase-9 expression and ovarian cancer invasion
-
DOI 10.1158/1541-7786.MCR-07-0366
-
Belotti D, Calcagno C, Garofalo A, Caronia D, Riccardi E, Giavazzi R et al. Vascular endothelial growth factor stimulates organ-specific host matrix metalloproteinase-9 expression and ovarian cancer invasion. Mol Cancer Res 2008; 6: 525-534. (Pubitemid 351521834)
-
(2008)
Molecular Cancer Research
, vol.6
, Issue.4
, pp. 525-534
-
-
Belotti, D.1
Calcagno, C.2
Garofalo, A.3
Caronia, D.4
Riccardi, E.5
Giavazzi, R.6
Taraboletti, G.7
-
62
-
-
71349085560
-
Serum cytokines in follicular lymphoma. Correlation of TGF-beta and VEGF with survival
-
Labidi SI, Menetrier-Caux C, Chabaud S, Chassagne C, Sebban C, Gargi T et al. Serum cytokines in follicular lymphoma. Correlation of TGF-beta and VEGF with survival. Ann Hematol 2009; 89: 25-33.
-
(2009)
Ann Hematol
, vol.89
, pp. 25-33
-
-
Labidi, S.I.1
Menetrier-Caux, C.2
Chabaud, S.3
Chassagne, C.4
Sebban, C.5
Gargi, T.6
-
63
-
-
41349110211
-
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma
-
DOI 10.1182/blood-2007-07-100115
-
Chen L, Monti S, Juszczynski P, Daley J, Chen W, Witzig TE et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood 2008; 111: 2230-2237. (Pubitemid 351451430)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2230-2237
-
-
Chen, L.1
Monti, S.2
Juszczynski, P.3
Daley, J.4
Chen, W.5
Witzig, T.E.6
Habermann, T.M.7
Kutok, J.L.8
Shipp, M.A.9
-
64
-
-
77952886100
-
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
-
Buchner M, Baer C, Prinz G, Dierks C, Burger M, Zenz T et al. Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood 2010; 115: 4497-4506.
-
(2010)
Blood
, vol.115
, pp. 4497-4506
-
-
Buchner, M.1
Baer, C.2
Prinz, G.3
Dierks, C.4
Burger, M.5
Zenz, T.6
-
65
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010; 115: 2578-2585.
-
(2010)
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
Johnston, P.B.4
Vose, J.M.5
Lacasce, A.6
|