Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

World Journal of Gastroenterology

Volumn 10, Issue 12, 2004, Pages 1815-1818

  Wang, Shui ^a   Ding, Yong Bin ^a   Chen, Guo Yu ^a   Xia, Jian Guo ^a   Wu, Zhen Yan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN KINASE SYK;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 3142711022     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i12.1815     Document Type: Article

References (33)

1. Kim JP. Surgical results in gastric cancer. Semin surg oncol 1999; 17:132-138
2. Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L. Overexpression of VCAM-1 is associated with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J Gastroenterol 2003; 9: 1409-1414
3. Sada K, Takano T, Yanagi S, Yamamura H. Structure and function of Syk protein-tyrosine kinase. J Biochem 2001;130: 177-186
4. Toyama T, Iwase H, Yamashita H, Hara Y, Omoto Y, Sugiura H, Zhang Z, Fujii Y. Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer. Cancer Lett 2003; 189: 97-102
5. Li L, Shaw PE. Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. J Biol Chem 2002; 277: 17397-17405
6. Coopman PJ, Do MT, Barth M, Bowden ET, Hayes AJ, Basyuk E, Blancato JK, Vezza PR, McLeskey SW, Mangeat PH, Mueller SC. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000; 406: 742-747
7. Stewart Z, Pietenpol J. Syk: a new player in the field of breast cancer. Breast Cancer Res 2001; 3: 5-7
8. Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol 1999; 144: 777-788
9. 6-methyiguanine-DNA methyltransferase promoter region as a marker of gene silencing. Mol Carcinogenesis 1999; 24: 85-89
10. Zhang J, Siraganian RP. CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells. J Immunol 1999; 163: 2508-2516
11. Zhu DM, Tibbles HE, Vassilev AO, Uckun FM. SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells. Leuk Lymphoma 2002; 43: 2165-2170
12. Chen L, Widhopf G, Huynh L, Rassenti L, Rai KR, Weiss A, Kipps TJ. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002; 100: 4609-4614
13. Palmieri G, Tullio V, Zingoni A, Piccoli M, Frati L, Lopez-Botet M, Santoni A. CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells. J Immunol 1999; 162: 7181-7188
14. Chu DH, Morita CT, Weiss A. The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol Rev 1998; 165: 167-180
15. Murphy M, Schnall R, Venter DJ, Barnett L, Bertoncello I, Thien CB, Langdon WY, Dowtell DD. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol 1998; 18: 4872-4882
16. Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol 2003; 4: 565-472
17. Goodman PA, Jurana B, Wood CM, Uckun F. Genomic studies of the spleen protein tyrosine kinase locus reveal a complex promoter structure and several genetic variants. Leuk Lymphoma 2002; 43: 1627-1635
18. Goodman PA, Wood CM, Vassilev A, Mao C, Uckun FM. Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia. Oncogene 2001; 20: 3969-3978
19. Mahabeleshwar GH, Kundu GC. Syk, a protein tyrosine kinase suppresses the cell motility and nuclear factor kB mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3′-kinase activity in breast cancer cells. J Biol Chem 2003; 278: 6209-6221
20. Paolini R, Molfetta R, Beitz LO, Zhang J, Scharenberg AM, Piccoli M, Frati L, Siraganian R, Santoni A. Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells. J Biol Chem 2002; 277: 36940-36947
21. Carter W, Hoying JB, Boswell C, Williams SK. HER2/neu over-expression induces endothelial cell retraction. Int J Cancer 2001; 91: 295-299
22. Qiu Y, Kung HJ. Signaling network of the Btk family kinase. Oncogene 2000; 19: 5651-5661
23. Okamura S, Ng C, Koyama K, Takei Y, Arakawa H, Monden M, Nakamura Y. Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system. Oncol Res 1999; 11: 281-285
24. Dong G, Loukinova E, Chen Z, Gangi L, Chanturita TI, Liu ET, Van Waes C. Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway. Cancer Res 2001; 61: 4797-4808
25. Yuan Y, Mendez R, Sahin A, Dai JL. Hypermethylation leads to silencing of the SYK gene in human breast cancer. Cancer Res 2001; 61: 5558-5561
26. Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L. Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of gastric carcinoma in surgically treated patients. World J Gastroenterol 2004; 10: 182-185
27. Buchholz TA, Wazer DE. Molecular biology and genetics of breast cancer development: a clinical perspective. Semin Radiat Oncol 2002; 12: 285-295
28. Arber N, Shapira I, Katan J, Stern B, Fabian I, Halpern Z. Activation of c-k ras mutations in human gastrointest inal tumors. Gastroentrerology 2000; 118: 1045-1050
29. Balaian L, Zhong RK, Ball ED. The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression. Exp Hematol 2003; 31: 363-371
30. Djeu JY, Jiang K, Wei S. A view to a kill: signals triggering cytotoxicity. Clin Cancer Res 2002; 8: 636-640
31. Uckun FM, Sudbeck EA, Mao C, Ghosh S, Liu XP, Vassilev AO, Navara CS, Narla RK. Structure-based design of novel anticancer agents. Curr Cancer Drug Targets 2001; 1: 59-71
32. Xu R, Seger R, Pecht I. Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling. J Immunol 1999; 163: 1110-1114
33. Wang L, Duke L, Zhang PS, Arlinghaus RB, Symmans WF, Sahin A, Mendez R, Dai JL. Alternative splicing disrupts a nuclear localization signal in spleen tyrosine that is require for invasion suppression in breast cancer. Cancer Res 2003; 63: 4724-4730