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Volumn 127, Issue 5, 2010, Pages 1081-1095

MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells

Author keywords

Angiogenesis; Lung cancer; MMP 2; siRNA; VEGF

Indexed keywords

ADENOVIRAL GELATINASE A SIRNA; ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR 8; GELATINASE A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VITRONECTIN RECEPTOR; COLLAGEN; LAMININ; LUCIFERASE; MATRIGEL; MESSENGER RNA; MMP2 PROTEIN, HUMAN; PROTEIN KINASE B; PROTEOGLYCAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 77955496933     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25134     Document Type: Article
Times cited : (190)

References (45)
  • 2
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3:401-10.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 3
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: Structure, assembly and role in tumour angiogenesis
    • DOI 10.1038/nrc1094
    • Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 2003;3:422-33. (Pubitemid 37328846)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 422-433
    • Kalluri, R.1
  • 4
    • 0034000699 scopus 로고    scopus 로고
    • VEGF receptor signaling in tumor angiogenesis
    • McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist 2000;5 (Suppl 1):3-10. (Pubitemid 30225450)
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 3-10
    • McMahon, G.1
  • 5
    • 0345258488 scopus 로고    scopus 로고
    • 2on Proliferative Cells
    • Banerjee SN, Sengupta K, Banerjee S, Saxena NK, Banerjee SK. 2-Methoxyestradiol exhibits a biphasic effect on VEGF-A in tumor cells and upregulation is mediated through ERalpha: a possible signaling pathway associated with the impact of 2-ME2 on proliferative cells. Neoplasia 2003;5:417-26. (Pubitemid 37475650)
    • (2003) Neoplasia , vol.5 , Issue.5 , pp. 417-426
    • Banerjee, S.N.1    Sengupta, K.2    Banerjee, S.3    Saxena, N.K.4    Banerjee, S.K.5
  • 6
    • 1242272855 scopus 로고    scopus 로고
    • Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    • DOI 10.1016/j.semcancer.2003.09.016
    • Mercurio AM, Bachelder RE, Bates RC, Chung J. Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin. Semin Cancer Biol 2004;14:115-22. (Pubitemid 38234753)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.2 , pp. 115-122
    • Mercurio, A.M.1    Bachelder, R.E.2    Bates, R.C.3    Chung, J.4
  • 7
    • 0030512608 scopus 로고    scopus 로고
    • Transgenic mouse models of tumour angiogenesis: The angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models
    • DOI 10.1016/S0959-8049(96)00401-7, PII S0959804996004017
    • Hanahan D, Christofori G, Naik P, Arbeit J Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. Eur J Cancer 32A:2386-93, 1996. (Pubitemid 27080776)
    • (1996) European Journal of Cancer Part a , vol.32 , Issue.14 , pp. 2386-2393
    • Hanahan, D.1    Christofori, G.2    Naik, P.3    Arbeit, J.4
  • 8
    • 31344474845 scopus 로고    scopus 로고
    • Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
    • DOI 10.1016/j.lungcan.2005.09.005, PII S0169500205004988
    • Bremnes RM, Camps C, Sirera R. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 2006;51:143-58. (Pubitemid 43144358)
    • (2006) Lung Cancer , vol.51 , Issue.2 , pp. 143-158
    • Bremnes, R.M.1    Camps, C.2    Sirera, R.3
  • 9
    • 33744812156 scopus 로고    scopus 로고
    • Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non-small-cell lung cancer
    • DOI 10.1016/j.lungcan.2006.02.009, PII S0169500206001735
    • Seto T, Higashiyama M, Funai H, Imamura F, Uematsu K, Seki N, Eguchi K, Yamanaka T, Ichinose Y. Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non-small-cell lung cancer. Lung Cancer 2006;53:91-6. (Pubitemid 43831360)
    • (2006) Lung Cancer , vol.53 , Issue.1 , pp. 91-96
    • Seto, T.1    Higashiyama, M.2    Funai, H.3    Imamura, F.4    Uematsu, K.5    Seki, N.6    Eguchi, K.7    Yamanaka, T.8    Ichinose, Y.9
  • 10
    • 0030893967 scopus 로고    scopus 로고
    • Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity
    • Volpert OV, Dameron KM, Bouck N. Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity. Oncogene. 1997;14:1495-502. (Pubitemid 27182439)
    • (1997) Oncogene , vol.14 , Issue.12 , pp. 1495-1502
    • Volpert, O.V.1    Dameron, K.M.2    Bouck, N.3
  • 12
    • 0033194117 scopus 로고    scopus 로고
    • PIK3CA: Determining its role in cellular proliferation and ovarian cancer
    • Andrew S. PIK3CA: determining its role in cellular proliferation and ovarian cancer. Clin Genet 1999;56:190-1.
    • (1999) Clin Genet , vol.56 , pp. 190-191
    • Andrew, S.1
  • 13
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • DOI 10.1023/B:APPT.0000045801.15585.dd
    • Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004;9:667-76. (Pubitemid 40941196)
    • (2004) Apoptosis , vol.9 , Issue.6 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 15
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 16
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/ phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5. (Pubitemid 30183422)
    • (2000) Cancer Research , vol.60 , Issue.6 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.-M.6    Simons, J.W.7    Semenza, G.L.8
  • 17
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia- Inducible factor 1
    • DOI 10.1074/jbc.271.30.17771
    • Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization. DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 1996;271:17771-8. (Pubitemid 26250751)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.30 , pp. 17771-17778
    • Jiang, B.-H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 18
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001;21:3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 19
    • 24344458927 scopus 로고    scopus 로고
    • Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells
    • DOI 10.1091/mbc.E04-12-1087
    • Trisciuoglio D, Iervolino A, Zupi G, Del Bufalo D. Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells. Mol Biol Cell 2005;16:4153-62. (Pubitemid 41262885)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.9 , pp. 4153-4162
    • Trisciuoglio, D.1    Iervolino, A.2    Zupi, G.3    Del Bufalo, D.4
  • 21
  • 27
    • 33749569829 scopus 로고    scopus 로고
    • Adenovirus-mediated siRNA against MMP-2 suppresses tumor growth and lung metastasis in mice
    • Chetty C, Bhoopathi P, Joseph P, Chittivelu S, Rao JS, Lakka SS. Adenovirus-mediated siRNA against MMP-2 suppresses tumor growth and lung metastasis in mice. Mol Cancer Ther 2006;5:2289-99.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2289-2299
    • Chetty, C.1    Bhoopathi, P.2    Joseph, P.3    Chittivelu, S.4    Rao, J.S.5    Lakka, S.S.6
  • 28
    • 49649093187 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2- Down-regulated lung cancer
    • Chetty C, Lakka SS, Bhoopathi P, Kunigal S, Geiss R, Rao JS. Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2- down-regulated lung cancer. Cancer Res 2008;68:4736-45.
    • (2008) Cancer Res , vol.68 , pp. 4736-4745
    • Chetty, C.1    Lakka, S.S.2    Bhoopathi, P.3    Kunigal, S.4    Geiss, R.5    Rao, J.S.6
  • 29
    • 36849042742 scopus 로고    scopus 로고
    • MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line
    • DOI 10.1038/sj.onc.1210584, PII 1210584
    • Chetty C, Bhoopathi P, Lakka SS, Rao JS. MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line. Oncogene 2007;26:7675-83. (Pubitemid 350224224)
    • (2007) Oncogene , vol.26 , Issue.55 , pp. 7675-7683
    • Chetty, C.1    Bhoopathi, P.2    Lakka, S.S.3    Rao, J.S.4
  • 30
    • 0031983123 scopus 로고    scopus 로고
    • Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells
    • DOI 10.1074/jbc.273.1.143
    • Bafetti LM, Young TN, Itoh Y, Stack MS. Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells. J Biol Chem 1998;273:143-9. (Pubitemid 28042187)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.1 , pp. 143-149
    • Bafetti, L.M.1    Young, T.N.2    Itoh, Y.3    Stack, M.S.4
  • 32
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-4.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 33
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • DOI 10.1210/er.18.1.4
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25. (Pubitemid 27076453)
    • (1997) Endocrine Reviews , vol.18 , Issue.1 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 37
    • 0037081306 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis
    • Deryugina EI, Soroceanu L, Strongin AY. Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis. Cancer Res 2002;62:580-8.
    • (2002) Cancer Res , vol.62 , pp. 580-588
    • Deryugina, E.I.1    Soroceanu, L.2    Strongin, A.Y.3
  • 38
    • 49649084712 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma
    • Kargiotis O, Chetty C, Gondi CS, Tsung AJ, Dinh DH, Gujrati M, Lakka SS, Kyritsis AP, Rao JS. Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma. Oncogene 2008;27:4830-40.
    • (2008) Oncogene , vol.27 , pp. 4830-4840
    • Kargiotis, O.1    Chetty, C.2    Gondi, C.S.3    Tsung, A.J.4    Dinh, D.H.5    Gujrati, M.6    Lakka, S.S.7    Kyritsis, A.P.8    Rao, J.S.9
  • 40
    • 0141482154 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: Implications for ascites formation
    • Belotti D, Paganoni P, Manenti L, Garofalo A, Marchini S, Taraboletti G, Giavazzi R. Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. Cancer Res 2003;63:5224-9.
    • (2003) Cancer Res , vol.63 , pp. 5224-5229
    • Belotti, D.1    Paganoni, P.2    Manenti, L.3    Garofalo, A.4    Marchini, S.5    Taraboletti, G.6    Giavazzi, R.7
  • 41
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
    • Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 2002;16:771-80.
    • (2002) FASEB J , vol.16 , pp. 771-780
    • Humar, R.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5
  • 43
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 2002;90:1243-50.
    • (2002) Circ Res , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 44
    • 0035417897 scopus 로고    scopus 로고
    • Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type- 1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma
    • Seftor RE, Seftor EA, Koshikawa N, Meltzer PS, Gardner LM, Bilban M, Stetler-Stevenson WG, Quaranta V, Hendrix MJ. Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type- 1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Cancer Res 2001;61:6322-7.
    • (2001) Cancer Res , vol.61 , pp. 6322-6327
    • Seftor, R.E.1    Seftor, E.A.2    Koshikawa, N.3    Meltzer, P.S.4    Gardner, L.M.5    Bilban, M.6    Stetler-Stevenson, W.G.7    Quaranta, V.8    Hendrix, M.J.9
  • 45
    • 0042941848 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry
    • Hess AR, Seftor EA, Seftor RE, Hendrix MJ. Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res 2003;63:4757-62.
    • (2003) Cancer Res , vol.63 , pp. 4757-4762
    • Hess, A.R.1    Seftor, E.A.2    Seftor, R.E.3    Hendrix, M.J.4


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