The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)-mediated neutrophil migration

Blood

Volumn 108, Issue 12, 2006, Pages 3919-3927

  Schymeinsky, Jurgen ^b   Sindrilaru, Anca ^b   Frommhold, David ^b   Sperandio, Markus ^b   Gerstl, Ronald ^b   Then, Cornelia ^b   Mócsai, Attila ^b   Scharffetter Kochanek, Karin ^b   Walzog, Barbara ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 INTEGRIN; CD11 ANTIGEN; CD18 ANTIGEN; GUANINE NUCLEOTIDE; PROTEIN KINASE SYK;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHUS PHENOMENON; ARTICLE; BINDING SITE; BONE MARROW; CELL DIFFERENTIATION; CELL MIGRATION; CREMASTER MUSCLE; DOWN REGULATION; EDEMA; ENZYME ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LAMELLIPODIUM; LEUKOCYTE ADHERENCE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE;

EID: 33845268014     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-12-030387     Document Type: Article

References (40)

1. Muller WA. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 2003;24:327-334.
2. Moser B, Wolf M, Walz A, Loetscher P. Chemokines: multiple levels of leukocyte migration control. Trends Immunol. 2004;25:75-84.
3. Van Haastert PJ, Devreotes PN. Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol. 2004;5:626-634.
4. Li Z, Hannigan M, Mo Z, et al. Directional sensing requires Gβγ-mediated PAK1 and PIXα-dependent activation of Cdc42. Cell. 2003;114:215-227.
5. Kinashi T. Intracellular signalling controlling integrin activation in lymphocytes. Nat Rev Immunol. 2005;5:546-559.
6. Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med. 1987;38:174-195.
7. 2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J Leukoc Biol. 2003;74:260-269.
8. Yan SR, Huang M, Berton G. Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen. J Immunol. 1997;158:1902-1910.
9. Miura Y, Tohyama Y, Hishita T, et al. Pyk2 and Syk participate in functional activation of granulocytic HL-60 cells in a different manner. Blood. 2000;96:1733-1739.
10. Kiefer F, Brumell J, Al-Alawi N, et al. The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils. Mol Cell Biol. 1998;18:4209-4220.
11. Minami Y, Nakagawa Y, Kawahara A, et al. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway. Immunity. 1995;2:89-100.
12. Berton G, Mocsai A, Lowell CA. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 2005;26:208-214.
13. Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 1995;378:303-306.
14. Turner M, Mee PJ, Costello PS, et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995;378:298-302.
15. Poole A, Gibbins JM, Turner M, et al. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 1997;16:2333-2341.
16. Obergfell A, Eto K, Mocsai A, et al. Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002;157:265-275.
17. Sada K, Takano T, Yanagi S, Yamura H. Structure and function of Syk protein-tyrosine kinase. J Biochem. 2001;130:177-186.
18. Plow EF, Haas TA, Zhang L, Loftus J, Smith JW. Ligand binding to integrins. J Biol Chem. 2000;275:21785-21788.
19. Mócsai A, Zhou M, Meng F, Tybulewicz VL, Lowell CA. Syk is required for integrin signaling in neutrophils. Immunity. 2002;16:547-558.
20. Schymeinsky J, Then C, Walzog B. The non-receptor tyrosine kinase Syk regulates lamellipodium formation and site-directed migration of human leukocytes. J Cell Physiol. 2005;204:614-622.
21. Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A. Functional and physical interactions of Syk family kinases with the Vav protooncogene product. Immunity. 1996;5:591-604.
22. Turner M, Billadeau DD. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol. 2002;2:476-486.
23. Srinivasan S, Wang F, Glavas S, et al. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol. 2003;160:375-385.
24. Vicente-Manzanares M, Cruz-Adalia A, Martin-Cofreces NB, et al. Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav. Blood. 2005;105:3026-3034.
25. Vedham V, Phee H, Coggeshall KM. Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol. 2005;25:4211-4220.
26. Scharffetter-Kochanek K, Lu H, Norman K, et al. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med. 1998;188:119-131.
27. Takada Y, Aggarwal BB. TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-κB activation, and apoptosis. J Immunol. 2004;173:1066-1077.
28. Ory DS, Neugeboren BA, Mulligan RC. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A. 1996;93:11400-11406.
29. Zigmond SH. Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J Cell Biol. 1977;75:606-616.
30. Sunderkotter C, Seeliger S, Schonlau F, et al. Different pathways leading to cutaneous leukocytoclastic vasculitis in mice. Exp Dermatol. 2001;10:391-404.
31. 1 and myofibroblast differentiation. EMBO J. 2005;24:3400-3410.
32. Sperandio M, Thatte A, Foy D, et al. Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice. Blood. 2001;97:3812-3819.
33. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil SJ. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998;8:1289-1299.
34. López-Lago M, Lee H, Cruz C, Movilla N, Bustelo XR. Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. Mol Cell Biol. 2000;20:1678-1691.
35. 2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-282.
36. 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. Proc Natl Acad Sci U S A. 1996;93:8431-8436.
37. 2 integrin-mediated adhesion of human neutrophils. J Biol Chem. 2003;278:24181-24188.
38. Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA. G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood. 2003;101:4155-4163.
39. Marder SR, Chenoweth DE, Goldstein IM, Perez HD. Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg. J Immunol. 1985;134:3325-3331.
40. Baumann U, Kohl J, Tschernig T, et al. A codominant role of FcγRI/III and C5aR in the reverse Arthus reaction. J Immunol. 2000;164:1065-1070.