Racemisation of N-Fmoc phenylglycine under mild microwave-SPPS and conventional stepwise SPPS conditions: Attempts to develop strategies for overcoming this

Journal of Peptide Science

Volumn 18, Issue 5, 2012, Pages 302-311

  Elsawy, Mohamed A ^a   Hewage, Chandralal ^b   Walker, Brian ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

(1D) and (2D) NMR; Conventional stepwise SPPS; DMTMM; ESI MS; Fmoc phenylglycine; Microwave SPPS; Peptide diastereoisomers; Racemisation; RP HPLC; Super active esters

Indexed keywords

9 FLUORENYLMETHOXYCARBONYLPHENYLGLYCINE; ALANYLVALYLPROLYLPHENYLALANYLTYROSINAMIDE; AMINO ACID DERIVATIVE; PHENYLGLYCINE; PIPERIDINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONVENTIONAL SOLID PHASE PEPTIDE SYNTHESIS; CROSS COUPLING REACTION; DEPROTECTION REACTION; DIASTEREOISOMER; EPIMERIZATION; MICROWAVE RADIATION; MICROWAVE SOLID PHASE PEPTIDE SYNTHESIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; RACEMIZATION; SOLID PHASE SYNTHESIS;

GLYCINE; MAGNETIC RESONANCE IMAGING; MICROWAVES; PEPTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84859630612     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2398     Document Type: Article

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