Synthesis of sterically-hindered peptidomimetics using 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride

Tetrahedron Letters

Volumn 49, Issue 37, 2008, Pages 5359-5362

  Shieh, Wen Chung ^a   Chen, Zhuoliang ^b   Xue, Song ^a   McKenna, Joe ^a   Wang, Run Ming ^b   Prasad, Kapa ^a   Repič, Oljan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

4 (4,6 Dimethoxy 1,3,5 triazine 2 yl) 4 methyl morpholinium chloride; DMTMM; Racemization control; Sterically hindered peptide synthesis

Indexed keywords

4 (4,6 DIMETHOXY 1,3,5 TRIAZINE 2 YL) 4 METHYL MORPHOLINIUM CHLORIDE; BENZOTRIAZOLE DERIVATIVE; CHLORIDE; HYDROXY BENZOTRIAZOLE; O (BENZOTRIAZOL 1 YL) N,N,N',N' TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; PHOSPHATE;

ARTICLE; ARYLATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 48149102475     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.06.119     Document Type: Article

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18. 3) δ 8.78 (d, J = 1.9 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 7.92 (t, J = 2.2 Hz, 1H), 7.85 (dd, J = 5.4, 3.5 Hz, 2H), 7.20 (t, J = 8.5 Hz, 2H), 5.22 (dd, J = 4.7, 3.5 Hz, 1H), 4.64 (t, J = 7.3 Hz, 1H), 4.03 (dd, J = 10.1, 7.3 Hz, 1H), 3.78-3.87 (m, 1H), 2.78 (s, 3H), 2.36-2.45 (m, 1H), 2.03-2.13 (m, 2H), 1.87-1.96 (m, 1H), 1.50-1.74 (m, 6H), 1.46 (s, 9H), 1.32 (d, J = 6.9 Hz, 3H), 0.87-1.21 (m, 6H).
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