Preparation and intestinal absorption of L-Dopa-D-phenylglycine

Journal of Food and Drug Analysis

Volumn 10, Issue 2, 2002, Pages 81-87

  Wang, Hui Po ^a   Fan, Yang Bin ^a   Lu, Hsiaw Hwa ^a   Hsu, Wen Li ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Dipeptide mimetics; Intestinal absorption; L Dopa D phenylglycine; PepT1

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFRADINE; DIPEPTIDE; GLYCINE; LEVO DOPA DEXTRO PHENYLGLYCINE; LEVODOPA; OLIGOPEPTIDE; PHENYLGLYCINE; PROLINE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; DRUG UPTAKE; FIRST PASS EFFECT; INTESTINE ABSORPTION; INTESTINE BRUSH BORDER; INTESTINE PERFUSION; JEJUNUM; MALE; MEMBRANE VESICLE; NONHUMAN; PROTON TRANSPORT; RAT; STEADY STATE;

ANIMALIA;

EID: 0036049946     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Levodopa pharmacology, pharmacokinetics and pharmacodynamics
2. Dopaminergic agonists in the treatment of Parkinson's disease: A Review
3. Parkinson's disease: Prospects for improved drug therapy
4. Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of levodopa and amino acids in patients with Parkinson's disease
5. Dietary factors in the management of Parkinson's disease
6. The effect of 1-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man
7. Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on a specific probe, SQ-29852
8. Immuno-localization of H + /Peptide cotransporter in rat digestive tract
9. Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: Enalapril and fosinopril
10. Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial caco-2 cells
11. Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors
12. Functional expression of transporter for beta-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines
13. Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal caco-2 cells
14. Inhibitory effects of angiotensin-converting enzyme inhibitor on cefroxadine uptake by rabbit small intestinal brush border membrane vesicles
15. Transcellular transport of oral cephalosporins in human intestinal epithelial cells, caco-2: Interaction with dipeptide transport systems in apical and basolateral membranes
16. Uptake of cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, caco-2
17. Uptake of cefadroxil derivatives into rat intestinal brush border membrane vesicles
18. Studies on the uptake of dipeptides in brush border membrane vesicle from rat intestine
19. Absorption of peptide and peptide mimetic drugs
20. Intestinal absorption studies on peptido mimetic prodrugs of α-methyldopa
21. Synthesis, intestinal absorption and pharmacological activities of a novel tripeptide mimetic dopamine prodrug
22. Disodium (R,R)-5-[[2-(3-chlorophenyl)-2-hydroxyethy1]-amino]propy1]- 1, 3-benzodioxole-2,2-dicarboxy-late (Cl 316,243). a potent β-adrenergic agonist virtually specific for B3 receptor. A promising antidiabetic and antiobesity Agent
23. Preparation and stability studies on dipeptide mimetic α-methyldopa prodrugs
24. Kinetics and mechanism of in vitro uptake of amino-β-lactam antibiotics by rat small intestine and relation to the intact peptide transport system
25. Use of the peptide carrier system to improve the intestinal absorption of 1-α-methyldopa : Carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of 1-α-methyldopa
26. Influence of d-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs
27. Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
28. Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities