메뉴 건너뛰기




Volumn 7, Issue 4, 2012, Pages

Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: A fine-mapping study in chinese population

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; DNA FLANKING REGION; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HHEX GENE; HUMAN; IDE GENE; KIF11 GENE; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; ASIAN; CASE CONTROL STUDY; CHROMOSOME 10; CHROMOSOME MAP; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED;

EID: 84859597728     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035060     Document Type: Article
Times cited : (32)

References (33)
  • 1
    • 78649911257 scopus 로고    scopus 로고
    • International Diabetes Federation, Brussels, Belgium, International Diabetes Federation
    • International Diabetes Federation (2006) Diabetes Atlas. 3rd ed Brussels, Belgium International Diabetes Federation.
    • (2006) Diabetes Atlas. 3rd Ed
  • 2
    • 77950263954 scopus 로고    scopus 로고
    • Prevalence of diabetes among men and women in China
    • Yang W, Lu J, Weng J, Jia W, Ji L, et al. (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362: 1090-1101.
    • (2010) N Engl J Med , vol.362 , pp. 1090-1101
    • Yang, W.1    Lu, J.2    Weng, J.3    Jia, W.4    Ji, L.5
  • 3
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, Dina C, Shen L, et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445: 881-885.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Shen, L.5
  • 5
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research
    • Saxena R, Voight BF, et al. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2
  • 6
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3    Willer, C.J.4    Li, Y.5
  • 7
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3    Frayling, T.M.4    Elliott, K.S.5
  • 8
    • 40949087723 scopus 로고    scopus 로고
    • Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    • Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, et al. (2008) Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57: 791-795.
    • (2008) Diabetes , vol.57 , pp. 791-795
    • Omori, S.1    Tanaka, Y.2    Takahashi, A.3    Hirose, H.4    Kashiwagi, A.5
  • 9
    • 67650248695 scopus 로고    scopus 로고
    • Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
    • Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, et al. (2009) Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58: 1690-1699.
    • (2009) Diabetes , vol.58 , pp. 1690-1699
    • Takeuchi, F.1    Serizawa, M.2    Yamamoto, K.3    Fujisawa, T.4    Nakashima, E.5
  • 10
    • 50449104632 scopus 로고    scopus 로고
    • Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6719 Asians
    • Ng MC, Park KS, Oh B, Tam CH, Cho YM, et al. (2008) Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6719 Asians. Diabetes 57: 2226-2233.
    • (2008) Diabetes , vol.57 , pp. 2226-2233
    • Ng, M.C.1    Park, K.S.2    Oh, B.3    Tam, C.H.4    Cho, Y.M.5
  • 11
    • 70449433016 scopus 로고    scopus 로고
    • PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    • Hu C, Zhang R, Wang C, Wang J, Ma X, et al. (2009) PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS One 4: e7643.
    • (2009) PLoS One , vol.4
    • Hu, C.1    Zhang, R.2    Wang, C.3    Wang, J.4    Ma, X.5
  • 12
    • 77952701364 scopus 로고    scopus 로고
    • Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population
    • Han X, Luo Y, Ren Q, Zhang X, Wang F, et al. (2010) Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 11: 81.
    • (2010) BMC Med Genet , vol.11 , pp. 81
    • Han, X.1    Luo, Y.2    Ren, Q.3    Zhang, X.4    Wang, F.5
  • 13
    • 77953438355 scopus 로고    scopus 로고
    • Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population
    • Lin Y, Li P, Cai L, Zhang B, Tang X, et al. (2010) Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet 11: 97.
    • (2010) BMC Med Genet , vol.11 , pp. 97
    • Lin, Y.1    Li, P.2    Cai, L.3    Zhang, B.4    Tang, X.5
  • 14
    • 78650563356 scopus 로고    scopus 로고
    • Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese
    • Zhou DZ, Liu Y, Zhang D, Liu SM, Yu L, et al. (2010) Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese. J Hum Genet 55: 810-815.
    • (2010) J Hum Genet , vol.55 , pp. 810-815
    • Zhou, D.Z.1    Liu, Y.2    Zhang, D.3    Liu, S.M.4    Yu, L.5
  • 15
    • 75149150236 scopus 로고    scopus 로고
    • Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore
    • Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL, et al. (2010) Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab 95: 390-397.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 390-397
    • Tan, J.T.1    Ng, D.P.2    Nurbaya, S.3    Ye, S.4    Lim, X.L.5
  • 16
    • 56349170898 scopus 로고    scopus 로고
    • Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    • Wu Y, Li H, Loos RJ, Yu Z, Ye X, et al. (2008) Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 57: 2834-2842.
    • (2008) Diabetes , vol.57 , pp. 2834-2842
    • Wu, Y.1    Li, H.2    Loos, R.J.3    Yu, Z.4    Ye, X.5
  • 17
    • 78649526616 scopus 로고    scopus 로고
    • Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies
    • Xu M, Bi Y, Xu Y, Yu B, Huang Y, et al. (2010) Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS One 5: e14022.
    • (2010) PLoS One , vol.5
    • Xu, M.1    Bi, Y.2    Xu, Y.3    Yu, B.4    Huang, Y.5
  • 18
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS, (2004) Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 131: 797-806.
    • (2004) Development , vol.131 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3    Zaret, K.S.4
  • 19
    • 0042822110 scopus 로고    scopus 로고
    • An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures
    • Bennett RG, Hamel FG, Duckworth WC, (2003) An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures. Diabetes 52: 2315-2320.
    • (2003) Diabetes , vol.52 , pp. 2315-2320
    • Bennett, R.G.1    Hamel, F.G.2    Duckworth, W.C.3
  • 20
    • 0037390039 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    • Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, et al. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 100: 4162-4167.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4162-4167
    • Farris, W.1    Mansourian, S.2    Chang, Y.3    Lindsley, L.4    Eckman, E.A.5
  • 21
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748.
    • (1959) J Natl Cancer Inst , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 23
    • 38149040036 scopus 로고    scopus 로고
    • Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population
    • Furukawa Y, Shimada T, Furuta H, Matsuno S, Kusuyama A, et al. (2007) Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 93: 310-314.
    • (2007) J Clin Endocrinol Metab , vol.93 , pp. 310-314
    • Furukawa, Y.1    Shimada, T.2    Furuta, H.3    Matsuno, S.4    Kusuyama, A.5
  • 24
    • 79952309502 scopus 로고    scopus 로고
    • Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes
    • Cai Y, Yi J, Ma Y, Fu D, (2011) Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes. Mutagenesis 26: 309-314.
    • (2011) Mutagenesis , vol.26 , pp. 309-314
    • Cai, Y.1    Yi, J.2    Ma, Y.3    Fu, D.4
  • 25
    • 13244291649 scopus 로고    scopus 로고
    • Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
    • Foley AC, Mercola M, (2005) Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes Dev 19: 387-396.
    • (2005) Genes Dev , vol.19 , pp. 387-396
    • Foley, A.C.1    Mercola, M.2
  • 26
    • 24944482530 scopus 로고    scopus 로고
    • Hex stimulates the hepatocyte nuclear factor 1alpha-mediated activation of transcription
    • Tanaka H, Yamamoto T, Ban T, Satoh S, Tanaka T, et al. (2005) Hex stimulates the hepatocyte nuclear factor 1alpha-mediated activation of transcription. Arch Biochem Biophys 442: 117-124.
    • (2005) Arch Biochem Biophys , vol.442 , pp. 117-124
    • Tanaka, H.1    Yamamoto, T.2    Ban, T.3    Satoh, S.4    Tanaka, T.5
  • 27
    • 65549157361 scopus 로고    scopus 로고
    • The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort
    • Pivovarova O, Nikiforova VJ, Pfeiffer AF, Rudovich N, (2009) The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort. Diabetes Metab Res Rev 25: 156-162.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 156-162
    • Pivovarova, O.1    Nikiforova, V.J.2    Pfeiffer, A.F.3    Rudovich, N.4
  • 28
    • 35449001954 scopus 로고    scopus 로고
    • Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    • Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, et al. (2007) Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 56: 3101-3104.
    • (2007) Diabetes , vol.56 , pp. 3101-3104
    • Pascoe, L.1    Tura, A.2    Patel, S.K.3    Ibrahim, I.M.4    Ferrannini, E.5
  • 29
    • 36849011549 scopus 로고    scopus 로고
    • Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    • Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, et al. (2007) Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 56: 3105-3111.
    • (2007) Diabetes , vol.56 , pp. 3105-3111
    • Grarup, N.1    Rose, C.S.2    Andersson, E.A.3    Andersen, G.4    Nielsen, A.L.5
  • 30
    • 38849129636 scopus 로고    scopus 로고
    • Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    • Staiger H, Machicao F, Stefan N, Tschritter O, Thamer C, et al. (2007) Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2: e832.
    • (2007) PLoS One , vol.2
    • Staiger, H.1    Machicao, F.2    Stefan, N.3    Tschritter, O.4    Thamer, C.5
  • 31
    • 40749087319 scopus 로고    scopus 로고
    • A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    • Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, et al. (2008) A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 57: 514-517.
    • (2008) Diabetes , vol.57 , pp. 514-517
    • Staiger, H.1    Stancáková, A.2    Zilinskaite, J.3    Vänttinen, M.4    Hansen, T.5
  • 32
    • 69849107894 scopus 로고    scopus 로고
    • Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies
    • Ruchat SM, Elks CE, Loos RJ, Vohl MC, Weisnagel SJ, et al. (2009) Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. Acta Diabetol 46: 217-226.
    • (2009) Acta Diabetol , vol.46 , pp. 217-226
    • Ruchat, S.M.1    Elks, C.E.2    Loos, R.J.3    Vohl, M.C.4    Weisnagel, S.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.