Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum

Journal of Biomedical Science

Volumn 19, Issue 1, 2012, Pages

  Myre, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

secretase; Dictyostelium discoideum; Hirano bodies; Huntingtin; Model organism; Neurodegeneration; Neurotransmitter homologues; Presenilin

Indexed keywords

ACTIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; HUNTINGTIN; PRESENILIN 1; PRESENILIN 2; HTT PROTEIN, HUMAN; NERVE PROTEIN; SECRETASE;

ALZHEIMER DISEASE; CELL FATE; CHEMOTAXIS; DEGENERATIVE DISEASE; DICTYOSTELIUM DISCOIDEUM; EXPERIMENTAL MODEL; GENE FUNCTION; GENOME; HIRANO BODY; HUMAN; HUNTINGTON CHOREA; LIFE CYCLE; LYSOSOME; MITOCHONDRION; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PATHOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; ARTICLE; BIOLOGICAL MODEL; DICTYOSTELIUM; GENETICS; METABOLISM; TRANSGENIC ORGANISM;

AMOEBA (GENUS); DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; EUKARYOTA;

AMYLOID PRECURSOR PROTEIN SECRETASES; DICTYOSTELIUM; HUMANS; HUNTINGTON DISEASE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; ORGANISMS, GENETICALLY MODIFIED;

EID: 84859502363     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-19-41     Document Type: Review

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