메뉴 건너뛰기




Volumn 5, Issue 3, 2012, Pages 285-293

Signification of hypermethylated in cancer 1 (HIC1) as tumor suppressor gene in tumor progression

Author keywords

Epigenetic modification; HIC1; Tumor microenviroment; Tumor progression

Indexed keywords

CHEMOKINE RECEPTOR CXCR7; DNA; MICRORNA; SIRTUIN 1; TUMOR MARKER;

EID: 84859497210     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-012-0103-1     Document Type: Article
Times cited : (26)

References (82)
  • 1
    • 0029014425 scopus 로고
    • P53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
    • Wales MM et al (1995) p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med 1(6):570-577
    • (1995) Nat Med , vol.1 , Issue.6 , pp. 570-577
    • Wales, M.M.1
  • 2
    • 56149093770 scopus 로고    scopus 로고
    • HIC1 (Hypermethylated in cancer 1) epigenetic silencing in tumors
    • Fleuriel C et al (2009) HIC1 (hypermethylated in cancer 1) epigenetic silencing in tumors. Int J Biochem Cell Biol 41(1):26-33
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.1 , pp. 26-33
    • Fleuriel, C.1
  • 3
    • 79952199274 scopus 로고    scopus 로고
    • Inactivation of the hypermethylated in cancer 1 tumour suppressor—not just a question of promoter hypermethylation?
    • Jenal M, et al. (2010) Inactivation of the hypermethylated in cancer 1 tumour suppressor—not just a question of promoter hypermethylation? Swiss Med Wkly 140(w13106)
    • (2010) Swiss Med Wkly , vol.140
    • Jenal, M.1
  • 4
    • 0037312934 scopus 로고    scopus 로고
    • Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrumofmalignant tumors
    • Chen WY et al (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrumofmalignant tumors. Nat Genet 33(2):197-202
    • (2003) Nat Genet , vol.33 , Issue.2 , pp. 197-202
    • Chen, W.Y.1
  • 5
    • 5444259434 scopus 로고    scopus 로고
    • Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis
    • Chen W et al (2004) Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Canc Cell 6(4):387-398
    • (2004) Canc Cell , vol.6 , Issue.4 , pp. 387-398
    • Chen, W.1
  • 6
    • 41149154521 scopus 로고    scopus 로고
    • Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
    • Briggs KJ et al (2008) Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev 22(6):770-785
    • (2008) Genes Dev , vol.22 , Issue.6 , pp. 770-785
    • Briggs, K.J.1
  • 7
    • 73349114319 scopus 로고    scopus 로고
    • Implication of HIC1 (Hypermethylated in cancer 1) in the DNA damage response
    • Dehennaut V, Leprince D (2009) Implication of HIC1 (hypermethylated in cancer 1) in the DNA damage response. Bull Canc 96 (11):E66-E72
    • (2009) Bull Canc , vol.96 , Issue.11 , pp. E66-E72
    • Dehennaut, V.1    Leprince, D.2
  • 8
    • 85040705198 scopus 로고    scopus 로고
    • Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation
    • Boulay G, et al. (2011) Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation. J Biol Chem
    • (2011) J Biol Chem
    • Boulay, G.1
  • 9
    • 84857241099 scopus 로고    scopus 로고
    • Receptor tyrosyne kinase Epha2 is a direct target-gene of Hic1 (Hypermethylated in cancer 1)
    • Foveau B, et al. (2012) Receptor tyrosyne kinase Epha2 is a direct target-gene of Hic1 (hypermethylated in cancer 1). J Biol Chem
    • (2012) J Biol Chem
    • Foveau, B.1
  • 10
    • 0034639710 scopus 로고    scopus 로고
    • Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome
    • Carter MG et al (2000) Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet 9(3):413-419
    • (2000) Hum Mol Genet , vol.9 , Issue.3 , pp. 413-419
    • Carter, M.G.1
  • 11
    • 0035793579 scopus 로고    scopus 로고
    • Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATAless promoter positively regulated by p53
    • Guerardel C et al (2001) Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATAless promoter positively regulated by p53. J Biol Chem 276(5):3078-3089
    • (2001) J Biol Chem , vol.276 , Issue.5 , pp. 3078-3089
    • Guerardel, C.1
  • 12
    • 2542580146 scopus 로고    scopus 로고
    • Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1
    • Pinte S et al (2004) Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. Oncogene 23(22):4023-4031
    • (2004) Oncogene , vol.23 , Issue.22 , pp. 4023-4031
    • Pinte, S.1
  • 13
    • 33645500652 scopus 로고    scopus 로고
    • Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1
    • Britschgi C et al (2006) Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. Oncogene 25(14):2030-2039
    • (2006) Oncogene , vol.25 , Issue.14 , pp. 2030-2039
    • Britschgi, C.1
  • 14
    • 33751268943 scopus 로고    scopus 로고
    • Identification and functional characterization of a novel unspliced transcript variant of HIC-1 in human cancer cells exposed to adverse growth conditions
    • Mondal AM et al (2006) Identification and functional characterization of a novel unspliced transcript variant of HIC-1 in human cancer cells exposed to adverse growth conditions. Cancer Res 66(21):10466-10477
    • (2006) Cancer Res , vol.66 , Issue.21 , pp. 10466-10477
    • Mondal, A.M.1
  • 15
    • 0029099016 scopus 로고
    • The BTB/POZ domain: A new proteinprotein interaction motif common to DNA-and actin-binding proteins
    • Albagli O et al (1995) The BTB/POZ domain: a new proteinprotein interaction motif common to DNA-and actin-binding proteins. Cell Growth Differ 6(9):1193-1198
    • (1995) Cell Growth Differ , vol.6 , Issue.9 , pp. 1193-1198
    • Albagli, O.1
  • 16
    • 34548105127 scopus 로고    scopus 로고
    • Sequence and structural analysis of BTB domain proteins
    • Stogios PJ et al (2005) Sequence and structural analysis of BTB domain proteins. Genome Biol 6(10):R82
    • (2005) Genome Biol , vol.6 , Issue.10 , pp. R82
    • Stogios, P.J.1
  • 17
    • 33750333540 scopus 로고    scopus 로고
    • POZ for effect-POZ-ZF transcription factors in cancer and development
    • Kelly KF, Daniel JM (2006) POZ for effect-POZ-ZF transcription factors in cancer and development. Trends Cell Biol 16(11):578-587
    • (2006) Trends Cell Biol , vol.16 , Issue.11 , pp. 578-587
    • Kelly, K.F.1    Daniel, J.M.2
  • 18
    • 4644346198 scopus 로고    scopus 로고
    • The tumor suppressor gene HIC1 (Hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: Definition of its consensus binding sequence and analysis of its DNA binding and repressive properties
    • Pinte S et al (2004) The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. J Biol Chem 279 (37):38313-38324
    • (2004) J Biol Chem , vol.279 , Issue.37 , pp. 38313-38324
    • Pinte, S.1
  • 19
    • 9144242434 scopus 로고    scopus 로고
    • Mechanism of SMRTcorepressor recruitment by the BCL6 BTB domain
    • Ahmad KF et al (2003) Mechanism of SMRTcorepressor recruitment by the BCL6 BTB domain. Mol Cell 12(6):1551-1564
    • (2003) Mol Cell , vol.12 , Issue.6 , pp. 1551-1564
    • Ahmad, K.F.1
  • 20
    • 38949165374 scopus 로고    scopus 로고
    • Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer
    • Ghetu AF et al (2008) Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell 29(3):384-391
    • (2008) Mol Cell , vol.29 , Issue.3 , pp. 384-391
    • Ghetu, A.F.1
  • 21
    • 0033593036 scopus 로고    scopus 로고
    • Recruitment of SMRT/ N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: The case of HIC-1 and gammaFBP-B
    • Deltour S, Guerardel C, Leprince D (1999) Recruitment of SMRT/ N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc Natl Acad Sci U S A 96(26):14831-14836
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.26 , pp. 14831-14836
    • Deltour, S.1    Guerardel, C.2    Leprince, D.3
  • 22
    • 27544434763 scopus 로고    scopus 로고
    • Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    • Chen WY et al (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123(3):437-448
    • (2005) Cell , vol.123 , Issue.3 , pp. 437-448
    • Chen, W.Y.1
  • 23
    • 0032570012 scopus 로고    scopus 로고
    • The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved
    • Deltour S et al (1998) The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. Biochim Biophys Acta 1443(1-2):230-232
    • (1998) Biochim Biophys Acta , vol.1443 , Issue.1-2 , pp. 230-232
    • Deltour, S.1
  • 24
    • 34147208064 scopus 로고    scopus 로고
    • An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
    • Stankovic-Valentin N et al (2007) An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol 27(7):2661-2675
    • (2007) Mol Cell Biol , vol.27 , Issue.7 , pp. 2661-2675
    • Stankovic-Valentin, N.1
  • 25
    • 1842453272 scopus 로고    scopus 로고
    • Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1
    • Bertrand S et al (2004) Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1. Biochim Biophys Acta 1678(1):57-66
    • (2004) Biochim Biophys Acta , vol.1678 , Issue.1 , pp. 57-66
    • Bertrand, S.1
  • 26
    • 0036274143 scopus 로고    scopus 로고
    • The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif
    • Deltour S et al (2002) The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Mol Cell Biol 22(13):4890-4901
    • (2002) Mol Cell Biol , vol.22 , Issue.13 , pp. 4890-4901
    • Deltour, S.1
  • 27
    • 34447632818 scopus 로고    scopus 로고
    • Transcriptional regulation by C-terminal binding proteins
    • Chinnadurai G (2007) Transcriptional regulation by C-terminal binding proteins. Int J Biochem Cell Biol 39(9):1593-1607
    • (2007) Int J Biochem Cell Biol , vol.39 , Issue.9 , pp. 1593-1607
    • Chinnadurai, G.1
  • 28
    • 33144473786 scopus 로고    scopus 로고
    • A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    • Shalizi A et al (2006) A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 311(5763): 1012-1017
    • (2006) Science , vol.311 , Issue.5763 , pp. 1012-1017
    • Shalizi, A.1
  • 30
    • 85040645538 scopus 로고    scopus 로고
    • Epigenetic modifications in cancer
    • Kanwal R, Gupta S (2011) Epigenetic modifications in cancer. Clin Genet
    • (2011) Clin Genet
    • Kanwal, R.1    Gupta, S.2
  • 31
    • 0030211260 scopus 로고    scopus 로고
    • Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue
    • Morton RA Jr et al (1996) Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue. J Urol 156(2 Pt 1):512-516
    • (1996) J Urol , vol.156 , Issue.2 , pp. 512-516
    • Morton, R.A.1
  • 32
    • 0030830914 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: Its association with smoking history
    • Eguchi K et al (1997) DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history. Cancer Res 57(21):4913-4915
    • (1997) Cancer Res , vol.57 , Issue.21 , pp. 4913-4915
    • Eguchi, K.1
  • 33
    • 0035056396 scopus 로고    scopus 로고
    • Reduced HIC-1 gene expression in nonsmall cell lung cancer and its clinical significance
    • Hayashi M et al (2001) Reduced HIC-1 gene expression in nonsmall cell lung cancer and its clinical significance. Anticancer Res 21(1B):535-540
    • (2001) Anticancer Res , vol.21 , Issue.1B , pp. 535-540
    • Hayashi, M.1
  • 34
    • 0032559995 scopus 로고    scopus 로고
    • Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer
    • Fujii H et al (1998) Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Oncogene 16(16):2159-2164
    • (1998) Oncogene , vol.16 , Issue.16 , pp. 2159-2164
    • Fujii, H.1
  • 35
    • 0032498296 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis
    • Kanai Y et al (1998) DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett 122(1-2):135-141
    • (1998) Cancer Lett , vol.122 , Issue.1-2 , pp. 135-141
    • Kanai, Y.1
  • 36
    • 0033052844 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis
    • Kanai Y et al (1999) DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology 29(3):703-709
    • (1999) Hepatology , vol.29 , Issue.3 , pp. 703-709
    • Kanai, Y.1
  • 37
    • 0033737598 scopus 로고    scopus 로고
    • High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China
    • Huang J et al (2000) High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China. Carcinogenesis 21 (11):2019-2026
    • (2000) Carcinogenesis , vol.21 , Issue.11 , pp. 2019-2026
    • Huang, J.1
  • 38
    • 0035870280 scopus 로고    scopus 로고
    • Epigenetic patterns in the progression of esophageal adenocarcinoma
    • Eads CA et al (2001) Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res 61(8):3410-3418
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3410-3418
    • Eads, C.A.1
  • 39
    • 0344081258 scopus 로고    scopus 로고
    • Characteristic promoter hypermethylation signatures in male germ cell tumors
    • Koul S, et al. (2002) Characteristic promoter hypermethylation signatures in male germ cell tumors. Mol Cancer 1(8)
    • (2002) Mol Cancer , vol.1 , Issue.8
    • Koul, S.1
  • 40
    • 0036644901 scopus 로고    scopus 로고
    • Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
    • Rood BR et al (2002) Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma. Cancer Res 62(13):3794-3797
    • (2002) Cancer Res , vol.62 , Issue.13 , pp. 3794-3797
    • Rood, B.R.1
  • 41
    • 12444250673 scopus 로고    scopus 로고
    • Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms
    • Rathi A et al (2003) Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. Clin Cancer Res 9 (10 Pt 1):3674-3678
    • (2003) Clin Cancer Res , vol.9 , Issue.10 , pp. 3674-3678
    • Rathi, A.1
  • 42
    • 0242609163 scopus 로고    scopus 로고
    • Epigenetic silencing of the HIC-1 gene in human medulloblastomas
    • Waha A et al (2003) Epigenetic silencing of the HIC-1 gene in human medulloblastomas. J Neuropathol Exp Neurol 62(11): 1192-1201
    • (2003) J Neuropathol Exp Neurol , vol.62 , Issue.11 , pp. 1192-1201
    • Waha, A.1
  • 43
    • 2442651661 scopus 로고    scopus 로고
    • Analysis of HIC-1 methylation and transcription in human ependymomas
    • Waha A et al (2004) Analysis of HIC-1 methylation and transcription in human ependymomas. Int J Cancer 110(4):542-549
    • (2004) Int J Cancer , vol.110 , Issue.4 , pp. 542-549
    • Waha, A.1
  • 44
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • Nishida N et al (2008) Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 47(3):908-918
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 908-918
    • Nishida, N.1
  • 45
    • 0037531563 scopus 로고    scopus 로고
    • Distinct methylation profiles of glioma subtypes
    • Uhlmann K et al (2003) Distinct methylation profiles of glioma subtypes. Int J Cancer 106(1):52-59
    • (2003) Int J Cancer , vol.106 , Issue.1 , pp. 52-59
    • Uhlmann, K.1
  • 46
    • 0030909701 scopus 로고    scopus 로고
    • DNA methylation changes in hematologic malignancies: Biologic and clinical implications
    • Issa JP, Baylin SB, Herman JG (1997) DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia 11(Suppl 1):S7-S11
    • (1997) Leukemia , vol.11 , pp. SS7-S11
    • Issa, J.P.1    Baylin, S.B.2    Herman, J.G.3
  • 47
    • 0030969482 scopus 로고    scopus 로고
    • HIC1 hypermethylation is a late event in hematopoietic neoplasms
    • Issa JP et al (1997) HIC1 hypermethylation is a late event in hematopoietic neoplasms. Cancer Res 57(9):1678-1681
    • (1997) Cancer Res , vol.57 , Issue.9 , pp. 1678-1681
    • Issa, J.P.1
  • 48
    • 34547100073 scopus 로고    scopus 로고
    • SIRT1 is significantly elevated in mouse and human prostate cancer
    • Huffman DM et al (2007) SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67(14):6612-6618
    • (2007) Cancer Res , vol.67 , Issue.14 , pp. 6612-6618
    • Huffman, D.M.1
  • 49
    • 42249115336 scopus 로고    scopus 로고
    • Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma
    • Stocklein H et al (2008) Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. Oncogene 27 (18):2613-2625
    • (2008) Oncogene , vol.27 , Issue.18 , pp. 2613-2625
    • Stocklein, H.1
  • 50
    • 67650445737 scopus 로고    scopus 로고
    • Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients
    • Tseng RC et al (2009) Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. Neoplasia 11(8):763-770
    • (2009) Neoplasia , vol.11 , Issue.8 , pp. 763-770
    • Tseng, R.C.1
  • 51
    • 33646830130 scopus 로고    scopus 로고
    • Mechanism of fibroblast growth factorbinding protein 1 repression by TGF-beta
    • Briones VR et al (2006) Mechanism of fibroblast growth factorbinding protein 1 repression by TGF-beta. Biochem Biophys Res Commun 345(2):595-601
    • (2006) Biochem Biophys Res Commun , vol.345 , Issue.2 , pp. 595-601
    • Briones, V.R.1
  • 52
    • 77951877955 scopus 로고    scopus 로고
    • A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1
    • Zhang W et al (2010) A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene 29(17):2467-2476
    • (2010) Oncogene , vol.29 , Issue.17 , pp. 2467-2476
    • Zhang, W.1
  • 53
    • 84857241099 scopus 로고    scopus 로고
    • The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1)
    • Foveau B et al (2012) The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). J Biol Chem 287(8):5366-5378
    • (2012) J Biol Chem , vol.287 , Issue.8 , pp. 5366-5378
    • Foveau, B.1
  • 54
    • 59649089064 scopus 로고    scopus 로고
    • Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control
    • Zhang B et al (2009) Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control. Oncogene 28(5):651-661
    • (2009) Oncogene , vol.28 , Issue.5 , pp. 651-661
    • Zhang, B.1
  • 55
    • 67649586411 scopus 로고    scopus 로고
    • The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1
    • Jenal M et al (2009) The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Canc Res 7 (6):916-922
    • (2009) Mol Canc Res , vol.7 , Issue.6 , pp. 916-922
    • Jenal, M.1
  • 56
    • 33745744942 scopus 로고    scopus 로고
    • HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
    • Valenta T et al (2006) HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J 25 (11):2326-2337
    • (2006) EMBO J , vol.25 , Issue.11 , pp. 2326-2337
    • Valenta, T.1
  • 57
    • 77955616940 scopus 로고    scopus 로고
    • Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells
    • Van Rechem C et al (2010) Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. Mol Cell Biol 30 (16):4045-4059
    • (2010) Mol Cell Biol , vol.30 , Issue.16 , pp. 4045-4059
    • Van Rechem, C.1
  • 58
    • 73849090298 scopus 로고    scopus 로고
    • P57KIP2: Kipping the cell under control
    • Pateras IS et al (2009) p57KIP2: Kipping the cell under control. Mol Canc Res 7(12):1902-1919
    • (2009) Mol Canc Res , vol.7 , Issue.12 , pp. 1902-1919
    • Pateras, I.S.1
  • 59
    • 84857348808 scopus 로고    scopus 로고
    • Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation
    • Boulay G et al (2012) Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation. J Biol Chem 287(8):5379-5389
    • (2012) J Biol Chem , vol.287 , Issue.8 , pp. 5379-5389
    • Boulay, G.1
  • 60
    • 68949120893 scopus 로고    scopus 로고
    • Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1)
    • Van Rechem C et al (2009) Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). J Biol Chem 284(31):20927-20935
    • (2009) J Biol Chem , vol.284 , Issue.31 , pp. 20927-20935
    • Van Rechem, C.1
  • 61
    • 3242722919 scopus 로고    scopus 로고
    • REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
    • Di Marcotullio L et al (2004) REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A 101(29):10833-10838
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.29 , pp. 10833-10838
    • Di Marcotullio, L.1
  • 62
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates andmedulloblastoma in mouse patched mutants
    • Goodrich LV et al (1997) Altered neural cell fates andmedulloblastoma in mouse patched mutants. Science 277(5329):1109-1113
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1
  • 63
    • 28244467388 scopus 로고    scopus 로고
    • Hedgehog checkpoints in medulloblastoma: The chromosome 17p deletion paradigm
    • Ferretti E et al (2005) Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm. Trends Mol Med 11 (12):537-545
    • (2005) Trends Mol Med , vol.11 , Issue.12 , pp. 537-545
    • Ferretti, E.1
  • 64
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T (2001) Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-516
    • (2001) Cancer Res , vol.61 , Issue.2 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 65
    • 33947301272 scopus 로고    scopus 로고
    • Epigenetic signatures of stem-cell identity
    • Spivakov M, Fisher AG (2007) Epigenetic signatures of stem-cell identity. Nat Rev Genet 8(4):263-271
    • (2007) Nat Rev Genet , vol.8 , Issue.4 , pp. 263-271
    • Spivakov, M.1    Fisher, A.G.2
  • 66
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by polycomb in human embryonic stem cells
    • Lee TI et al (2006) Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125(2):301-313
    • (2006) Cell , vol.125 , Issue.2 , pp. 301-313
    • Lee, T.I.1
  • 67
    • 33846576622 scopus 로고    scopus 로고
    • Epigenetic stem cell signature in cancer
    • Widschwendter M et al (2007) Epigenetic stem cell signature in cancer. Nat Genet 39(2):157-158
    • (2007) Nat Genet , vol.39 , Issue.2 , pp. 157-158
    • Widschwendter, M.1
  • 68
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JE et al (2007) A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 39(2):237-242
    • (2007) Nat Genet , vol.39 , Issue.2 , pp. 237-242
    • Ohm, J.E.1
  • 69
    • 77957350610 scopus 로고    scopus 로고
    • Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
    • Kalari S, Pfeifer GP (2010) Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet 70 (277-308)
    • (2010) Adv Genet , vol.70 , pp. 277-308
    • Kalari, S.1    Pfeifer, G.P.2
  • 70
    • 38949108624 scopus 로고    scopus 로고
    • Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy
    • Saito K et al (2008) Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy. Canc Sci 99(2):253-259
    • (2008) Canc Sci , vol.99 , Issue.2 , pp. 253-259
    • Saito, K.1
  • 71
    • 54449085718 scopus 로고    scopus 로고
    • Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
    • Dumont N et al (2008) Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A 105(39):14867-14872
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.39 , pp. 14867-14872
    • Dumont, N.1
  • 72
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9(4):265-273
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 73
    • 43249121177 scopus 로고    scopus 로고
    • Stromal gene expression predicts clinical outcome in breast cancer
    • Finak G et al (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14(5):518-527
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 518-527
    • Finak, G.1
  • 74
    • 42549152045 scopus 로고    scopus 로고
    • No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    • Qiu W et al (2008) No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 40(5):650-655
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 650-655
    • Qiu, W.1
  • 75
    • 34249323034 scopus 로고    scopus 로고
    • Identification of epigenetically silenced genes in tumor endothelial cells
    • Hellebrekers DM et al (2007) Identification of epigenetically silenced genes in tumor endothelial cells. Cancer Res 67 (9):4138-4148
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4138-4148
    • Hellebrekers, D.M.1
  • 76
    • 84858288644 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in tumor microenvironment
    • Jing Y, et al. (2011) Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 1(29)
    • (2011) Cell Biosci , vol.1 , Issue.29
    • Jing, Y.1
  • 77
    • 84856748026 scopus 로고    scopus 로고
    • Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
    • Xia D et al (2012) Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224-226
    • (2012) Nat Med , vol.18 , Issue.2 , pp. 224-226
    • Xia, D.1
  • 78
    • 68749097208 scopus 로고    scopus 로고
    • MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
    • Ng EK et al (2009) MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer 101(4):699-706
    • (2009) Br J Cancer , vol.101 , Issue.4 , pp. 699-706
    • Ng, E.K.1
  • 79
    • 77953807423 scopus 로고    scopus 로고
    • Pharmacoepigenomics: Discovering therapeutic approaches and biomarkers for cancer therapy
    • Claes B, Buysschaert I, Lambrechts D (2010) Pharmacoepigenomics: discovering therapeutic approaches and biomarkers for cancer therapy. Heredity (Edinb) 105(1):152-160
    • (2010) Heredity (Edinb) , vol.105 , Issue.1 , pp. 152-160
    • Claes, B.1    Buysschaert, I.2    Lambrechts, D.3
  • 80
    • 27144509196 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
    • Lyko F, Brown R (2005) DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Canc Inst 97 (20):1498-1506
    • (2005) J Natl Canc Inst , vol.97 , Issue.20 , pp. 1498-1506
    • Lyko, F.1    Brown, R.2
  • 81
    • 84863020791 scopus 로고    scopus 로고
    • Effects of a novel DNA methyltransferase inhibitor zebularine on human lens epithelial cells
    • Zhou P, Lu Y, Sun XH (2012) Effects of a novel DNA methyltransferase inhibitor zebularine on human lens epithelial cells. Mol Vis 18(22-28)
    • (2012) Mol Vis , vol.18 , pp. 22-28
    • Zhou, P.1    Lu, Y.2    Sun, X.H.3
  • 82
    • 0037068379 scopus 로고    scopus 로고
    • 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman JK (2002) 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21(35):5483-5495
    • (2002) Oncogene , vol.21 , Issue.35 , pp. 5483-5495
    • Christman, J.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.