-
1
-
-
0029014425
-
P53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
-
Wales MM et al (1995) p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med 1(6):570-577
-
(1995)
Nat Med
, vol.1
, Issue.6
, pp. 570-577
-
-
Wales, M.M.1
-
2
-
-
56149093770
-
HIC1 (Hypermethylated in cancer 1) epigenetic silencing in tumors
-
Fleuriel C et al (2009) HIC1 (hypermethylated in cancer 1) epigenetic silencing in tumors. Int J Biochem Cell Biol 41(1):26-33
-
(2009)
Int J Biochem Cell Biol
, vol.41
, Issue.1
, pp. 26-33
-
-
Fleuriel, C.1
-
3
-
-
79952199274
-
Inactivation of the hypermethylated in cancer 1 tumour suppressor—not just a question of promoter hypermethylation?
-
Jenal M, et al. (2010) Inactivation of the hypermethylated in cancer 1 tumour suppressor—not just a question of promoter hypermethylation? Swiss Med Wkly 140(w13106)
-
(2010)
Swiss Med Wkly
, vol.140
-
-
Jenal, M.1
-
4
-
-
0037312934
-
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrumofmalignant tumors
-
Chen WY et al (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrumofmalignant tumors. Nat Genet 33(2):197-202
-
(2003)
Nat Genet
, vol.33
, Issue.2
, pp. 197-202
-
-
Chen, W.Y.1
-
5
-
-
5444259434
-
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis
-
Chen W et al (2004) Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Canc Cell 6(4):387-398
-
(2004)
Canc Cell
, vol.6
, Issue.4
, pp. 387-398
-
-
Chen, W.1
-
6
-
-
41149154521
-
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
-
Briggs KJ et al (2008) Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev 22(6):770-785
-
(2008)
Genes Dev
, vol.22
, Issue.6
, pp. 770-785
-
-
Briggs, K.J.1
-
7
-
-
73349114319
-
Implication of HIC1 (Hypermethylated in cancer 1) in the DNA damage response
-
Dehennaut V, Leprince D (2009) Implication of HIC1 (hypermethylated in cancer 1) in the DNA damage response. Bull Canc 96 (11):E66-E72
-
(2009)
Bull Canc
, vol.96
, Issue.11
, pp. E66-E72
-
-
Dehennaut, V.1
Leprince, D.2
-
8
-
-
85040705198
-
Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation
-
Boulay G, et al. (2011) Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation. J Biol Chem
-
(2011)
J Biol Chem
-
-
Boulay, G.1
-
9
-
-
84857241099
-
Receptor tyrosyne kinase Epha2 is a direct target-gene of Hic1 (Hypermethylated in cancer 1)
-
Foveau B, et al. (2012) Receptor tyrosyne kinase Epha2 is a direct target-gene of Hic1 (hypermethylated in cancer 1). J Biol Chem
-
(2012)
J Biol Chem
-
-
Foveau, B.1
-
10
-
-
0034639710
-
Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome
-
Carter MG et al (2000) Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet 9(3):413-419
-
(2000)
Hum Mol Genet
, vol.9
, Issue.3
, pp. 413-419
-
-
Carter, M.G.1
-
11
-
-
0035793579
-
Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATAless promoter positively regulated by p53
-
Guerardel C et al (2001) Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATAless promoter positively regulated by p53. J Biol Chem 276(5):3078-3089
-
(2001)
J Biol Chem
, vol.276
, Issue.5
, pp. 3078-3089
-
-
Guerardel, C.1
-
12
-
-
2542580146
-
Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1
-
Pinte S et al (2004) Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. Oncogene 23(22):4023-4031
-
(2004)
Oncogene
, vol.23
, Issue.22
, pp. 4023-4031
-
-
Pinte, S.1
-
13
-
-
33645500652
-
Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1
-
Britschgi C et al (2006) Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. Oncogene 25(14):2030-2039
-
(2006)
Oncogene
, vol.25
, Issue.14
, pp. 2030-2039
-
-
Britschgi, C.1
-
14
-
-
33751268943
-
Identification and functional characterization of a novel unspliced transcript variant of HIC-1 in human cancer cells exposed to adverse growth conditions
-
Mondal AM et al (2006) Identification and functional characterization of a novel unspliced transcript variant of HIC-1 in human cancer cells exposed to adverse growth conditions. Cancer Res 66(21):10466-10477
-
(2006)
Cancer Res
, vol.66
, Issue.21
, pp. 10466-10477
-
-
Mondal, A.M.1
-
15
-
-
0029099016
-
The BTB/POZ domain: A new proteinprotein interaction motif common to DNA-and actin-binding proteins
-
Albagli O et al (1995) The BTB/POZ domain: a new proteinprotein interaction motif common to DNA-and actin-binding proteins. Cell Growth Differ 6(9):1193-1198
-
(1995)
Cell Growth Differ
, vol.6
, Issue.9
, pp. 1193-1198
-
-
Albagli, O.1
-
16
-
-
34548105127
-
Sequence and structural analysis of BTB domain proteins
-
Stogios PJ et al (2005) Sequence and structural analysis of BTB domain proteins. Genome Biol 6(10):R82
-
(2005)
Genome Biol
, vol.6
, Issue.10
, pp. R82
-
-
Stogios, P.J.1
-
17
-
-
33750333540
-
POZ for effect-POZ-ZF transcription factors in cancer and development
-
Kelly KF, Daniel JM (2006) POZ for effect-POZ-ZF transcription factors in cancer and development. Trends Cell Biol 16(11):578-587
-
(2006)
Trends Cell Biol
, vol.16
, Issue.11
, pp. 578-587
-
-
Kelly, K.F.1
Daniel, J.M.2
-
18
-
-
4644346198
-
The tumor suppressor gene HIC1 (Hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: Definition of its consensus binding sequence and analysis of its DNA binding and repressive properties
-
Pinte S et al (2004) The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. J Biol Chem 279 (37):38313-38324
-
(2004)
J Biol Chem
, vol.279
, Issue.37
, pp. 38313-38324
-
-
Pinte, S.1
-
19
-
-
9144242434
-
Mechanism of SMRTcorepressor recruitment by the BCL6 BTB domain
-
Ahmad KF et al (2003) Mechanism of SMRTcorepressor recruitment by the BCL6 BTB domain. Mol Cell 12(6):1551-1564
-
(2003)
Mol Cell
, vol.12
, Issue.6
, pp. 1551-1564
-
-
Ahmad, K.F.1
-
20
-
-
38949165374
-
Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer
-
Ghetu AF et al (2008) Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell 29(3):384-391
-
(2008)
Mol Cell
, vol.29
, Issue.3
, pp. 384-391
-
-
Ghetu, A.F.1
-
21
-
-
0033593036
-
Recruitment of SMRT/ N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: The case of HIC-1 and gammaFBP-B
-
Deltour S, Guerardel C, Leprince D (1999) Recruitment of SMRT/ N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc Natl Acad Sci U S A 96(26):14831-14836
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.26
, pp. 14831-14836
-
-
Deltour, S.1
Guerardel, C.2
Leprince, D.3
-
22
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
Chen WY et al (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123(3):437-448
-
(2005)
Cell
, vol.123
, Issue.3
, pp. 437-448
-
-
Chen, W.Y.1
-
23
-
-
0032570012
-
The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved
-
Deltour S et al (1998) The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. Biochim Biophys Acta 1443(1-2):230-232
-
(1998)
Biochim Biophys Acta
, vol.1443
, Issue.1-2
, pp. 230-232
-
-
Deltour, S.1
-
24
-
-
34147208064
-
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
-
Stankovic-Valentin N et al (2007) An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol 27(7):2661-2675
-
(2007)
Mol Cell Biol
, vol.27
, Issue.7
, pp. 2661-2675
-
-
Stankovic-Valentin, N.1
-
25
-
-
1842453272
-
Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1
-
Bertrand S et al (2004) Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1. Biochim Biophys Acta 1678(1):57-66
-
(2004)
Biochim Biophys Acta
, vol.1678
, Issue.1
, pp. 57-66
-
-
Bertrand, S.1
-
26
-
-
0036274143
-
The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif
-
Deltour S et al (2002) The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Mol Cell Biol 22(13):4890-4901
-
(2002)
Mol Cell Biol
, vol.22
, Issue.13
, pp. 4890-4901
-
-
Deltour, S.1
-
27
-
-
34447632818
-
Transcriptional regulation by C-terminal binding proteins
-
Chinnadurai G (2007) Transcriptional regulation by C-terminal binding proteins. Int J Biochem Cell Biol 39(9):1593-1607
-
(2007)
Int J Biochem Cell Biol
, vol.39
, Issue.9
, pp. 1593-1607
-
-
Chinnadurai, G.1
-
28
-
-
33144473786
-
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
-
Shalizi A et al (2006) A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 311(5763): 1012-1017
-
(2006)
Science
, vol.311
, Issue.5763
, pp. 1012-1017
-
-
Shalizi, A.1
-
30
-
-
85040645538
-
Epigenetic modifications in cancer
-
Kanwal R, Gupta S (2011) Epigenetic modifications in cancer. Clin Genet
-
(2011)
Clin Genet
-
-
Kanwal, R.1
Gupta, S.2
-
31
-
-
0030211260
-
Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue
-
Morton RA Jr et al (1996) Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue. J Urol 156(2 Pt 1):512-516
-
(1996)
J Urol
, vol.156
, Issue.2
, pp. 512-516
-
-
Morton, R.A.1
-
32
-
-
0030830914
-
DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: Its association with smoking history
-
Eguchi K et al (1997) DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history. Cancer Res 57(21):4913-4915
-
(1997)
Cancer Res
, vol.57
, Issue.21
, pp. 4913-4915
-
-
Eguchi, K.1
-
33
-
-
0035056396
-
Reduced HIC-1 gene expression in nonsmall cell lung cancer and its clinical significance
-
Hayashi M et al (2001) Reduced HIC-1 gene expression in nonsmall cell lung cancer and its clinical significance. Anticancer Res 21(1B):535-540
-
(2001)
Anticancer Res
, vol.21
, Issue.1B
, pp. 535-540
-
-
Hayashi, M.1
-
34
-
-
0032559995
-
Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer
-
Fujii H et al (1998) Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Oncogene 16(16):2159-2164
-
(1998)
Oncogene
, vol.16
, Issue.16
, pp. 2159-2164
-
-
Fujii, H.1
-
35
-
-
0032498296
-
DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis
-
Kanai Y et al (1998) DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett 122(1-2):135-141
-
(1998)
Cancer Lett
, vol.122
, Issue.1-2
, pp. 135-141
-
-
Kanai, Y.1
-
36
-
-
0033052844
-
DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis
-
Kanai Y et al (1999) DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology 29(3):703-709
-
(1999)
Hepatology
, vol.29
, Issue.3
, pp. 703-709
-
-
Kanai, Y.1
-
37
-
-
0033737598
-
High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China
-
Huang J et al (2000) High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China. Carcinogenesis 21 (11):2019-2026
-
(2000)
Carcinogenesis
, vol.21
, Issue.11
, pp. 2019-2026
-
-
Huang, J.1
-
38
-
-
0035870280
-
Epigenetic patterns in the progression of esophageal adenocarcinoma
-
Eads CA et al (2001) Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res 61(8):3410-3418
-
(2001)
Cancer Res
, vol.61
, Issue.8
, pp. 3410-3418
-
-
Eads, C.A.1
-
39
-
-
0344081258
-
Characteristic promoter hypermethylation signatures in male germ cell tumors
-
Koul S, et al. (2002) Characteristic promoter hypermethylation signatures in male germ cell tumors. Mol Cancer 1(8)
-
(2002)
Mol Cancer
, vol.1
, Issue.8
-
-
Koul, S.1
-
40
-
-
0036644901
-
Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
-
Rood BR et al (2002) Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma. Cancer Res 62(13):3794-3797
-
(2002)
Cancer Res
, vol.62
, Issue.13
, pp. 3794-3797
-
-
Rood, B.R.1
-
41
-
-
12444250673
-
Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms
-
Rathi A et al (2003) Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. Clin Cancer Res 9 (10 Pt 1):3674-3678
-
(2003)
Clin Cancer Res
, vol.9
, Issue.10
, pp. 3674-3678
-
-
Rathi, A.1
-
42
-
-
0242609163
-
Epigenetic silencing of the HIC-1 gene in human medulloblastomas
-
Waha A et al (2003) Epigenetic silencing of the HIC-1 gene in human medulloblastomas. J Neuropathol Exp Neurol 62(11): 1192-1201
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, Issue.11
, pp. 1192-1201
-
-
Waha, A.1
-
43
-
-
2442651661
-
Analysis of HIC-1 methylation and transcription in human ependymomas
-
Waha A et al (2004) Analysis of HIC-1 methylation and transcription in human ependymomas. Int J Cancer 110(4):542-549
-
(2004)
Int J Cancer
, vol.110
, Issue.4
, pp. 542-549
-
-
Waha, A.1
-
44
-
-
40949161396
-
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
-
Nishida N et al (2008) Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 47(3):908-918
-
(2008)
Hepatology
, vol.47
, Issue.3
, pp. 908-918
-
-
Nishida, N.1
-
45
-
-
0037531563
-
Distinct methylation profiles of glioma subtypes
-
Uhlmann K et al (2003) Distinct methylation profiles of glioma subtypes. Int J Cancer 106(1):52-59
-
(2003)
Int J Cancer
, vol.106
, Issue.1
, pp. 52-59
-
-
Uhlmann, K.1
-
46
-
-
0030909701
-
DNA methylation changes in hematologic malignancies: Biologic and clinical implications
-
Issa JP, Baylin SB, Herman JG (1997) DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia 11(Suppl 1):S7-S11
-
(1997)
Leukemia
, vol.11
, pp. SS7-S11
-
-
Issa, J.P.1
Baylin, S.B.2
Herman, J.G.3
-
47
-
-
0030969482
-
HIC1 hypermethylation is a late event in hematopoietic neoplasms
-
Issa JP et al (1997) HIC1 hypermethylation is a late event in hematopoietic neoplasms. Cancer Res 57(9):1678-1681
-
(1997)
Cancer Res
, vol.57
, Issue.9
, pp. 1678-1681
-
-
Issa, J.P.1
-
48
-
-
34547100073
-
SIRT1 is significantly elevated in mouse and human prostate cancer
-
Huffman DM et al (2007) SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67(14):6612-6618
-
(2007)
Cancer Res
, vol.67
, Issue.14
, pp. 6612-6618
-
-
Huffman, D.M.1
-
49
-
-
42249115336
-
Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma
-
Stocklein H et al (2008) Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. Oncogene 27 (18):2613-2625
-
(2008)
Oncogene
, vol.27
, Issue.18
, pp. 2613-2625
-
-
Stocklein, H.1
-
50
-
-
67650445737
-
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients
-
Tseng RC et al (2009) Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. Neoplasia 11(8):763-770
-
(2009)
Neoplasia
, vol.11
, Issue.8
, pp. 763-770
-
-
Tseng, R.C.1
-
51
-
-
33646830130
-
Mechanism of fibroblast growth factorbinding protein 1 repression by TGF-beta
-
Briones VR et al (2006) Mechanism of fibroblast growth factorbinding protein 1 repression by TGF-beta. Biochem Biophys Res Commun 345(2):595-601
-
(2006)
Biochem Biophys Res Commun
, vol.345
, Issue.2
, pp. 595-601
-
-
Briones, V.R.1
-
52
-
-
77951877955
-
A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1
-
Zhang W et al (2010) A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene 29(17):2467-2476
-
(2010)
Oncogene
, vol.29
, Issue.17
, pp. 2467-2476
-
-
Zhang, W.1
-
53
-
-
84857241099
-
The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1)
-
Foveau B et al (2012) The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). J Biol Chem 287(8):5366-5378
-
(2012)
J Biol Chem
, vol.287
, Issue.8
, pp. 5366-5378
-
-
Foveau, B.1
-
54
-
-
59649089064
-
Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control
-
Zhang B et al (2009) Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control. Oncogene 28(5):651-661
-
(2009)
Oncogene
, vol.28
, Issue.5
, pp. 651-661
-
-
Zhang, B.1
-
55
-
-
67649586411
-
The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1
-
Jenal M et al (2009) The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Canc Res 7 (6):916-922
-
(2009)
Mol Canc Res
, vol.7
, Issue.6
, pp. 916-922
-
-
Jenal, M.1
-
56
-
-
33745744942
-
HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
-
Valenta T et al (2006) HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J 25 (11):2326-2337
-
(2006)
EMBO J
, vol.25
, Issue.11
, pp. 2326-2337
-
-
Valenta, T.1
-
57
-
-
77955616940
-
Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells
-
Van Rechem C et al (2010) Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. Mol Cell Biol 30 (16):4045-4059
-
(2010)
Mol Cell Biol
, vol.30
, Issue.16
, pp. 4045-4059
-
-
Van Rechem, C.1
-
58
-
-
73849090298
-
P57KIP2: Kipping the cell under control
-
Pateras IS et al (2009) p57KIP2: Kipping the cell under control. Mol Canc Res 7(12):1902-1919
-
(2009)
Mol Canc Res
, vol.7
, Issue.12
, pp. 1902-1919
-
-
Pateras, I.S.1
-
59
-
-
84857348808
-
Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation
-
Boulay G et al (2012) Loss of hypermethylated in cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through beta-2 adrenergic receptor (ADRB2) misregulation. J Biol Chem 287(8):5379-5389
-
(2012)
J Biol Chem
, vol.287
, Issue.8
, pp. 5379-5389
-
-
Boulay, G.1
-
60
-
-
68949120893
-
Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1)
-
Van Rechem C et al (2009) Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). J Biol Chem 284(31):20927-20935
-
(2009)
J Biol Chem
, vol.284
, Issue.31
, pp. 20927-20935
-
-
Van Rechem, C.1
-
61
-
-
3242722919
-
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
-
Di Marcotullio L et al (2004) REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A 101(29):10833-10838
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.29
, pp. 10833-10838
-
-
Di Marcotullio, L.1
-
62
-
-
0030866154
-
Altered neural cell fates andmedulloblastoma in mouse patched mutants
-
Goodrich LV et al (1997) Altered neural cell fates andmedulloblastoma in mouse patched mutants. Science 277(5329):1109-1113
-
(1997)
Science
, vol.277
, Issue.5329
, pp. 1109-1113
-
-
Goodrich, L.V.1
-
63
-
-
28244467388
-
Hedgehog checkpoints in medulloblastoma: The chromosome 17p deletion paradigm
-
Ferretti E et al (2005) Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm. Trends Mol Med 11 (12):537-545
-
(2005)
Trends Mol Med
, vol.11
, Issue.12
, pp. 537-545
-
-
Ferretti, E.1
-
64
-
-
0035863498
-
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
-
Wetmore C, Eberhart DE, Curran T (2001) Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-516
-
(2001)
Cancer Res
, vol.61
, Issue.2
, pp. 513-516
-
-
Wetmore, C.1
Eberhart, D.E.2
Curran, T.3
-
65
-
-
33947301272
-
Epigenetic signatures of stem-cell identity
-
Spivakov M, Fisher AG (2007) Epigenetic signatures of stem-cell identity. Nat Rev Genet 8(4):263-271
-
(2007)
Nat Rev Genet
, vol.8
, Issue.4
, pp. 263-271
-
-
Spivakov, M.1
Fisher, A.G.2
-
66
-
-
33646865180
-
Control of developmental regulators by polycomb in human embryonic stem cells
-
Lee TI et al (2006) Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125(2):301-313
-
(2006)
Cell
, vol.125
, Issue.2
, pp. 301-313
-
-
Lee, T.I.1
-
67
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
Widschwendter M et al (2007) Epigenetic stem cell signature in cancer. Nat Genet 39(2):157-158
-
(2007)
Nat Genet
, vol.39
, Issue.2
, pp. 157-158
-
-
Widschwendter, M.1
-
68
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
-
Ohm JE et al (2007) A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 39(2):237-242
-
(2007)
Nat Genet
, vol.39
, Issue.2
, pp. 237-242
-
-
Ohm, J.E.1
-
69
-
-
77957350610
-
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
-
Kalari S, Pfeifer GP (2010) Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet 70 (277-308)
-
(2010)
Adv Genet
, vol.70
, pp. 277-308
-
-
Kalari, S.1
Pfeifer, G.P.2
-
70
-
-
38949108624
-
Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy
-
Saito K et al (2008) Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy. Canc Sci 99(2):253-259
-
(2008)
Canc Sci
, vol.99
, Issue.2
, pp. 253-259
-
-
Saito, K.1
-
71
-
-
54449085718
-
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
-
Dumont N et al (2008) Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A 105(39):14867-14872
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.39
, pp. 14867-14872
-
-
Dumont, N.1
-
72
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
-
Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9(4):265-273
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.4
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
73
-
-
43249121177
-
Stromal gene expression predicts clinical outcome in breast cancer
-
Finak G et al (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14(5):518-527
-
(2008)
Nat Med
, vol.14
, Issue.5
, pp. 518-527
-
-
Finak, G.1
-
74
-
-
42549152045
-
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
-
Qiu W et al (2008) No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 40(5):650-655
-
(2008)
Nat Genet
, vol.40
, Issue.5
, pp. 650-655
-
-
Qiu, W.1
-
75
-
-
34249323034
-
Identification of epigenetically silenced genes in tumor endothelial cells
-
Hellebrekers DM et al (2007) Identification of epigenetically silenced genes in tumor endothelial cells. Cancer Res 67 (9):4138-4148
-
(2007)
Cancer Res
, vol.67
, Issue.9
, pp. 4138-4148
-
-
Hellebrekers, D.M.1
-
76
-
-
84858288644
-
Epithelial-mesenchymal transition in tumor microenvironment
-
Jing Y, et al. (2011) Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 1(29)
-
(2011)
Cell Biosci
, vol.1
, Issue.29
-
-
Jing, Y.1
-
77
-
-
84856748026
-
Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
-
Xia D et al (2012) Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224-226
-
(2012)
Nat Med
, vol.18
, Issue.2
, pp. 224-226
-
-
Xia, D.1
-
78
-
-
68749097208
-
MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
-
Ng EK et al (2009) MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer 101(4):699-706
-
(2009)
Br J Cancer
, vol.101
, Issue.4
, pp. 699-706
-
-
Ng, E.K.1
-
79
-
-
77953807423
-
Pharmacoepigenomics: Discovering therapeutic approaches and biomarkers for cancer therapy
-
Claes B, Buysschaert I, Lambrechts D (2010) Pharmacoepigenomics: discovering therapeutic approaches and biomarkers for cancer therapy. Heredity (Edinb) 105(1):152-160
-
(2010)
Heredity (Edinb)
, vol.105
, Issue.1
, pp. 152-160
-
-
Claes, B.1
Buysschaert, I.2
Lambrechts, D.3
-
80
-
-
27144509196
-
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
-
Lyko F, Brown R (2005) DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Canc Inst 97 (20):1498-1506
-
(2005)
J Natl Canc Inst
, vol.97
, Issue.20
, pp. 1498-1506
-
-
Lyko, F.1
Brown, R.2
-
81
-
-
84863020791
-
Effects of a novel DNA methyltransferase inhibitor zebularine on human lens epithelial cells
-
Zhou P, Lu Y, Sun XH (2012) Effects of a novel DNA methyltransferase inhibitor zebularine on human lens epithelial cells. Mol Vis 18(22-28)
-
(2012)
Mol Vis
, vol.18
, pp. 22-28
-
-
Zhou, P.1
Lu, Y.2
Sun, X.H.3
-
82
-
-
0037068379
-
5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
-
Christman JK (2002) 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21(35):5483-5495
-
(2002)
Oncogene
, vol.21
, Issue.35
, pp. 5483-5495
-
-
Christman, J.K.1
|