Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and implications for design of parasite selective inhibitors

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 11788-11797

  Wang, Huanchen ^a,e   Kunz, Stefan ^b   Chen, Gong ^c   Seebeck, Thomas ^b   Wan, Yiqian ^c   Robinson, Howard ^d   Martinelli, Sibylla ^b   Ke, Hengming ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c SUN YAT SEN UNIVERSITY   (China)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; CATALYTIC DOMAINS; CHAGAS DISEASE; DIRECT INTERACTIONS; DRUG TARGETS; ENZYMATIC ACTIVITIES; ENZYMATIC PROPERTIES; N-TERMINALS; PARASITE-; PHOSPHODIESTERASES; SELECTIVE INHIBITORS; SILDENAFIL; STRUCTURAL CHARACTERIZATION; STRUCTURAL STUDIES; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

BIOLOGY; DESIGN; ENZYME ACTIVITY; ESTERS; SCAFFOLDS;

ENZYME INHIBITION;

5 [2 ETHOXY 5 (N ISOPROPYLOXYCARBONYLAMINOSULFONYL) 1 METHYL 3 PROPYL 1H PYRAZOLO[4,3 D]PYRIMIDIN 7(6H)ONE]; CYCLIC AMP; CYCLIC GMP; PHOSPHODIESTERASE; PHOSPHODIESTERASE C; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; UNCLASSIFIED DRUG; WYQ 16;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; IC 50; KINETOPLASTIDA; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; TRYPANOSOMA CONGOLENSE; TRYPANOSOMA CRUZI; TRYPANOSOMA EVANSI;

AMINO ACID SEQUENCE; BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; KINETICS; MOLECULAR SEQUENCE DATA; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SULFONAMIDES; SURFACE PROPERTIES; TRYPANOSOMA CRUZI;

KINETOPLASTIDA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 84859478891     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.326777     Document Type: Article

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